Biomedical subjects

A-A Ramelet

Publications and source records attributed to A-A Ramelet.

5 recordsLinked to original sources

PubMed2006

Exercise-induced vasculitis.

BACKGROUND: Usually misdiagnosed and ignored in the literature, exercise-induced vasculitis (EIV) is not uncommon, occurring mostly in long-distance runners and in females after long walks, especially in hot weather. OBSERVATIONS: I report 23 otherwise healthy patients (22 females, 1 male) who developed EIV after walking or hiking in hot weather. Erythematous, urticarial or purpuric plaques arose on the lower legs, not involving skin compressed by socks. Symptoms included itch, pain, and burning sensation. Lesions resolved after some days. Relapses were frequent at further muscular exercise, and could be prevented in some cases by compression hosiery, manual lymphatic drainage, intake of oedema protective agents, or steroids (local or systemic). INVESTIGATIONS: Histopathology demonstrated leucocytoclastic vasculitis in five biopsies, and urticarial vasculitis in one. Extensive blood investigations have been performed in six patients and were negative. No clear relation with chronic venous disease (duplex or Doppler) had been established in 12 patients. CONCLUSIONS: I suggest denominating this condition exercise-induced vasculitis. This clinical entity is well defined, but poorly recognized. The presentation of 23 original cases demonstrates its reality.

Adult↗

PubMed2005

Venous leg ulcer: a meta-analysis of adjunctive therapy with micronized purified flavonoid fraction.

OBJECTIVE: To assess the effect of oral treatment with micronized purified flavonoid fraction (MPFF) on leg ulcer healing. DESIGN: Meta-analysis of randomised prospective studies using MPFF in addition to conventional treatment. MATERIALS AND METHODS: Five prospective, randomised, controlled studies in which 723 patients with venous ulcers were treated between 1996 and 2001 were identified. Conventional treatment (compression and local care) in addition to MPFF was compared to conventional treatment plus placebo in two studies (N = 309), or with conventional treatment alone in three studies (N = 414). The primary end point was complete ulcer healing at 6 months. RESULTS: At 6 months, the chance of healing ulcer was 32% better in patients treated with adjunctive MPFF than in those managed by conventional therapy alone (RRR: 32%; CI, 3-70%). This difference was present from month 2 (RRR: 44%; CI, 7-94%), and was associated with a shorter time to healing (16 versus 21 weeks; P = 0.0034). The main benefit of MPFF was present in the subgroup of ulcers between 5 and 10 cm2 in area (RRR: 40%; CI, 6-87%), and those present for 6-12 months duration (RRR: 44%; CI, 6-97%). CONCLUSION: These results confirm that venous ulcer healing is accelerated by MPFF treatment. MPFF might be a useful adjunct to conventional therapy in large and long standing ulcers.

Administration, Oral↗

PubMed2005

[What are the epidemiological data on the consequences of smoking-related increased risk in pregnant women? Dermatological consequences].

Smoking has numerous effects on skin. Some of them are well established, others are more debatable. Smoking is a cofactor of skin aging after chronic sun exposure, as demonstrated by recent histological, biochemical and cutaneous relief studies. Smoking is a well established risk factor of cutaneous, mucous membrane cancers, and some gynecologic cancers as well, in some cases increased by pregnancy. However, published studies have included small numbers of subjects. Some skin affections are worsened by smoking, and others might be improved. However scientific data on smoking and skin or pregnancy are both scarce.

Female↗

PubMed2002

Phlebectomy--cosmetic indications.

Ambulatory phlebectomy is a safe, aesthetic, effective and economical operative technique, which enables venous extraction with a special hook, assuring complete and definitive eradication of the veins. Minimal skin incisions (1-3 mm), or even needle punctures, usually result in little or no scarring. This aesthetic method is particularly indicated to treat unsightly varicose veins, such as reticular veins (popliteal fold, lateral thigh and leg), groin pudendal veins, veins of the ankles and the dorsal venous network of the foot. Curettage of telangiectasias is a less well-known technique, but it is also effective in removing networks of thick blue spider veins. Ambulatory phlebectomy of body areas other than the lower limbs include dilated periorbital, temporal or frontal venous networks and venous dilatation of the abdomen, upper limbs or dorsa of the hands.

Journal Article↗

PubMed2002

Phlebectomy. Technique, indications and complications.

Phlebectomy, first described by Aulus Cornelius Celsus (25 BC - 45 AD), was re-invented 40 years ago by Dr. Robert Müller, in Neuchâtel, Switzerland. This safe, esthetic, effective and economical operative technique has now been fully developed and adopted all over the world. Phlebectomy hooks enable venous extraction through minimal skin incisions (1-3 mm) or even needle punctures, assuring complete and definite eradication of the veins. The small size of the skin incisions usually results in little or no scarring, contrary to that found in classical venous surgery, and avoids the possible complications of sclerotherapy, such as skin necrosis or residual hyperpigmentation. Sites particularly appropriate for ambulatory phlebectomy include incompetent saphenous veins (except the sapheno-femoral and in most cases the sapheno-popliteal junctions), their major tributaries, perforating, groin pudendal veins, reticular veins (popliteal fold, lateral thigh and leg) and veins of the ankles and the dorsal venous network of the foot. Curettage of telangiectasias is a less well known indication, but it is also quite effective in removing networks of thick blue spider veins. Ambulatory phlebectomy of body areas, other than the legs, include dilated periorbital, temporal or frontal venous networks and venous dilatation of the abdomen, arms or dorsum of the hands. Long term results, if the indications and technique were correct, are excellent. Complications, in skillful hands, seldom occur. They may be classified as cutaneous, vascular, neurological or general and are usually benign.

Humans↗