Biomedical subjects

A-C Albertsson

Publications and source records attributed to A-C Albertsson.

3 recordsLinked to original sources

PubMed2005

Surface functionalization of degradable polymers by covalent grafting.

With a new non-destructive and solvent-free photografting technique, N-vinylpyrrolidone was covalently grafted onto the surfaces of degradable polymers; poly(l-lactide), poly(epsilon-caprolactone), poly(lactide-co-glycolide), and poly(trimethylene carbonate). The modified surfaces were characterized by XPS, ATR-FTIR, SEM, and cell growth tests. The wettability was markedly improved, as static contact angles changed from about 80 degrees for the pristine substrates to around 30 degrees after 30min of grafting. Well-defined surface topographies, such as micro-patterns, are preserved in the process since the graft layers are thin. The biological response, measured as cytotoxicity, showed that the modified films provide good substrates, comparable with optimized cell culture plastics, for the adhesion and proliferation of normal human keratinocytes and skin fibroblasts.

Biocompatible Materials↗

PubMed2003

Polyesters based on diacid monomers.

Polymers with ester linkages in their main chain comprise a family of polymers with immense diversity and versatility. This review deals with the preparation of such polymers from dicarboxylic acid monomers, and the result in terms of properties and applicability. Polyesters alone, and their copolymers with amides, anhydrides, urethanes, imides, ethers or other functional groups, offer countless opportunities to tune the properties of the resulting material within a broad range. Of particular interest is the inherent biodegradability of the ester linkage. Biodegradability is sought after in a wide range of applications, above all in the preparation of environmentally friendly polymers and biomedical materials for temporary surgical use and in drug delivery.

Animals↗

PubMedDate not supplied

Solvent free vapor phase photografting of maleic anhydride onto poly(ethylene terephthalate) and surface coupling of fluorinated probes, PEG, and an RGD-peptide.

Poly(ethylene terephthalate) (PET) was photografted in a solvent free vapor of maleic anhydride and benzophenone. After hydrolysis of the initially grafted succinic anhydride groups, the carboxylic PET surfaces were modified by coupling reactions in organic and aqueous solutions. 2,2,2-Trifluoroethylamine and diamino PEGs of molecular weight 3400 and 2000 were reacted with acid chloride groups obtained by treating the PET-COOH surface with PCl(5). Furthermore, fluoro substituted thiols and a cystein terminated RGD containing peptide were bound to PET-COOH surfaces via a disulfide link by a three step coupling sequence. Coupling yields and surface concentrations of the fluoro substituted ligands were calculated from ESCA data. The RGD-peptide surfaces were evaluated by cultivation with rat smooth muscle cells.

Amino Acid Sequence↗