7-Hydroxywithanolides from datura ferox
Three new withanolides were isolated from leaves of Datura ferox. Their structures were established as (17R,20S,22R)-5alpha,6alpha, 7beta,12alpha-tetrahydroxy-1-oxowitha-2,24-dienolide (1), (17R,20S, 22R,24S,25S)-24,25-epoxy-5alpha,6alpha,7beta, 12alpha-tetrahydroxy-1-oxowitha-2-enolide (2), and (17R,20S, 22R)-5alpha,6alpha-epoxy-7alpha-hydroxy-1,12-dioxowitha-2, 24-dienolide (3), using spectroscopic methods (NMR, MS) and molecular modeling.
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