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Abdelhamid Elgazzar

Publications and source records attributed to Abdelhamid Elgazzar.

6 recordsLinked to original sources
PubMed2006

Evaluation of left ventricular ejection fraction by the quantitative algorithms QGS, ECTb, LMC and LVGTF using gated myocardial perfusion SPECT: investigation of relative accuracy.

AIM: To compare the quantitative algorithms Emory Cardiac Toolbox (ECTb), quantitative gated SPECT (QGS), layer of maximum counts (LMC), and left ventricular global thickening fraction (LVGTF) using gated myocardial tomography in the calculation of the left ventricular ejection fraction using the regression without truth (RWT) technique. MATERIALS AND METHODS: Seventy-four consecutive patients were included in the study (59 males). All patients underwent stress-rest myocardial perfusion SPECT using Tc-tetrofosmin. Analysis of variance (ANOVA), the paired Student's t-test, the Pearson correlation coefficient and Bland-Altman were used for comparing the methods. The relative accuracy was performed by RWT. RESULTS: ANOVA revealed a significant difference among the methods in calculating the ejection fraction. RWT showed that ECTb and QGS outperformed the other two methods. The ECTb was slightly better than QGS, and LMC was slightly better than LVGTF. QGS and ECTb achieved good correlations in end diastolic volume, end systolic volume and ejection fraction measurements. One-way ANOVA demonstrated that QGS was the only software program affected by the category of the perfusion summed stress score (SSS), P=0.038. The ejection fraction determined by the QGS, ECTb and LVGTF methods correlated significantly with defect size (r=0.545, P<0.0001; r=0.530, P<0.0001; and r=0.419, P<0.0001, respectively), but the LMC method was not significantly correlated (r=0.216, P=0.067). CONCLUSIONS: There was a considerable variation among the quantitative gated SPECT methods in the evaluation of the ejection fraction. RWT revealed that the ECTb and QGS outperformed the other two methods with respect to the bias and precision of the measurements. Pair-wise correlations of the four methods ranged from mild to good with large agreement limits. Results of RWT provided important information in ranking the quantitative gated SPECT methods.

Algorithms↗
PubMed2006

Impact of three-phase bone scintigraphy on the diagnosis and treatment of complex regional pain syndrome type I or reflex sympathetic dystrophy.

OBJECTIVE: To determine the impact of three-phase bone scintigraphy (TPBS) on the diagnosis and management of complex regional pain syndrome type I (CRPSI) or reflex sympathetic dystrophy (RSD). SUBJECTS AND METHODS: Twenty consecutive patients with a recent clinical evidence of CRPSI were referred for TPBS as part of their routine management plan. All patients underwent neurological examinations with special attention to the evaluation of clinical features of vasomotor, sudomotor, motor and sensory dysfunction. Patients were followed prospectively. When both the clinical and TPBS results supported the diagnosis of CRPSI, patients were started on treatment. RESULTS: Of the 20 patients, TPBS supported the diagnosis of RSD in 9 who were treated with steroids and physiotherapy. Complete follow-up was available for 7 of them and all had a satisfactory response to treatment. For the remaining 11 patients RSD was diagnosed clinically but not confirmed by TPBS. On follow-up there was no evidence that TPBS failed to identify RSD in these 11 patients. CONCLUSION: The results indicate that TPBS confirmed the clinical diagnosis of RSD, and, more importantly, had a significant impact on its management.

Adult↗
PubMed2005

Assessment of left ventricular ejection fraction by four different methods using 99mTc tetrofosmin gated SPECT in patients with small hearts: correlation with gated blood pool.

AIM: To compare the currently available gated SPECT software programs, quantitative gated SPECT (QGS), Emory Cardiac Toolbox (ECTb), Left Ventricular Global Thickening Fraction (LVGTF), and the recently developed Layer of Maximum Count (LMC) method with equilibrium Gated Blood Pool (GBP) scintigraphy in calculating the ejection fraction in patients with small hearts. METHODS: Twenty patients with small hearts (end diastolic volume <85 ml) were collected for the study. Gated myocardial perfusion SPECT and planar GBP were performed for all patients. The four methods QGS, ECTb, and LVGTF and LMC were used for volumes estimation and ejection fraction calculation. RESULTS: ANOVA analysis revealed significant differences among the methods in ejection fraction estimation (P<0.0001). The mean ejection fraction by GBP was significantly overestimated by QGS and ECTb and LVGTF (P<0.0001, P<0.0001 and P=0.006, respectively). The mean ejection fraction by GBP was not significantly different from that by the LMC method (P=0.213). Ejection fraction measurements by QGS and ECTb yielded moderate correlation with GBP values (r=0.588, P=0.006; and r=0.564, P=0.010, respectively). The ejection fraction by the LMC method was marginally correlated but LVGTF showed a non-significant correlation with GBP (r=0.438, P=0.053; and r=0.155, P=0.515, respectively). Agreement analysis for ejection fraction estimation by QGS and ECTb demonstrated a non-significant correlation between the difference and the mean. The LMC method showed a non-significant trend to decrease the difference with GBP as the mean increased. However, the LVGTF method significantly increased the difference as the mean increased. CONCLUSION: The currently available gated SPECT methods have moderate to poor correlations in addition to wide agreement limits with gated blood pool studies in patients with small hearts. Improvement of these methods to achieve better results in such patients is recommended. The newly developed LMC method yielded better results in the group with small hearts but with low interchangeability with GBP studies.

Female↗
PubMed2003

Prominent Tc-99m MIBI skeletal uptake in renal osteodystrophy: a possible role for whole-body scanning.

Renal osteodystrophy is a process whereby renal failure causes profound bone disease. Effects on bone include osteosclerosis, osteomalacia, osteoporosis, pathologic fractures, aseptic necrosis of the hips, and bone pain. The authors present a case of renal osteodystrophy with intense Tc-99m 2-methoxy isobutyl isonitrile (MIBI) radiotracer uptake in the mandible and propose that Tc-99m MIBI may have a potential role in diagnosing renal osteodystrophy.

Bone and Bones↗