Biomedical subjects

Adriana Stanciu

Publications and source records attributed to Adriana Stanciu.

4 recordsLinked to original sources

PubMedDate not supplied

[New data about ITO cells].

Ito cells (the fat-storing cells) are stellate cells located in the space of Disse. They can be selectively stained with gold chloride, but their distinguishing feature in routine histological preparations is the presence of multiple lipid droplets in their cytoplasm. Ito cells have the capacity to accumulate exogenously administered vitamin A as retinyl esters in lipid droplets. The quantity of vitamin A, which is stuck into Ito cells, decreases progressively in liver injury, like chronic alcohol intake. Also, the fat-storing cells are the principal cellular source of collagen and other extracellular substances in normal as well as fibrotic liver. Liver injury is followed by an increase in the number of the fat-storing cells.

Adipocytes↗

PubMedDate not supplied

[Granular cells of the hepatic capillary sinuses--receptors].

Pit cells or hepatic natural killer (NK) cells represent an organ-associated NK cell population. They are situated in liver sinusoids and exert high spontaneous cytotoxic activity against tumor cell lines and may act as a primary defense barrier to metastasing tumor cells and to virus infections. Pit cells express two types of receptors on their cell membrane. One type activates NK cell killing (NCR or natural cytotoxicity receptors, as NKp46, NKp44, NKp30, NKG2D) by recognizing ill-defined molecules on target cells. The second type of receptors inhibits the lytic pathway by recognition of self class I MHC molecules and are represented by KIR or killer cell Ig-like receptors, as KIR2D, CD94/NKG2. Pit cells express on their cell membrane and other type of molecules as CD2, CD54, CD11a/CD18 and are CD3 negative.

Animals↗

PubMedDate not supplied

[Pulmonary alveolar proteinosis].

It is a disease of obscure cause that is characterized by the accumulation of a granular material that contains abundant lipid within the alveoli of lung. Pulmonary alveolar proteinosis (PAP) has been divided into a congenital and an adult form. The acquired form has been subdivided into a idiopathic form and a secondary form associated with a know disorder or exposure as silica, aluminium, titanium. Dyspnea and cough are the most common presenting symptoms. Chest pain, hemoptysis, fever and weight loss are variably reported. Pathogenesis remains unknown, but evidence points to a dysfunction of alveolar macrophages. Mice genetically deficient in granulocyte macrophagecolony stimulating factor (GM-CSF) show an alveolar proteinosis. A neutralizing antibody against GM-CSF was found in bronchoalveolar lavage fluid and serum of patients with idiopathic PAP. Currently, no specific therapy exists for pulmonary alveolar proteinosis, and sequential whole lung lavage is standard treatment.

Animals↗

PubMedDate not supplied

[Knodell and Metavir scoring systems--advantages and limits].

The study relies upon the analysis of hepatic biopsies from 36 adults hospitalised in "Infections Disease Clinical Hospital" Iaşi. The clinical diagnosis was chronic hepatitis. The histological exam revealed 33 cases of chronical hepatitis, 1 case of cirrhosis, 2 cases are still open to interpretation. The lesions have been interpreted according to Knodell and Metavir scoring systems. The scores are significantly important in identifying the grades of histological activity and the stages of the fibrosis. The result of these scoring systems allow the classification of the cases into aggressivity-based forms, the estimation of the prognosis and offer indication in therapy.

Adult↗