Biomedical subjects

Agata Czarnywojtek

Publications and source records attributed to Agata Czarnywojtek.

7 recordsLinked to original sources

PubMed2005

[Tobacco smoking in patients with hyperthyroidism].

The objective of this study was to determine the impact of cigarette smoking in hyperthyroidism patients. The study group included patients with Graves-Basedow disease (GB): n = 317 (32.9%), patients with Graves' ophthalmopathy (GO): n = 108 (11.2%), patients with toxic nodular goiter (TNG) n = 511 (53%) and 28 (2.9%) patients with toxic adenoma (TA). Evaluation of tabacco smoking and exposure to environmental tobacco smoke (ETS) was performed on the base of questionnaire acording to Fagerström test. The comparison of GO and GB indicate increased tabacco smoking in GO (OR = 0.36; 95%CI: 0.22-0.59). The frequencies of tacacco smoking displayed significantly increased in GB and TNG patients (OR=0.39; 95%CI: 0.28-0.56). Further analys of patients with GO and TA presented statistcal significance in group of smoking and non-smoking (OR=0.26; 95%CI: 0,073-0,95). In other cases we didn't found a significant influence of tobacco smoking on thyroid disease. The effect of smoking was more pronounced in Graves' patients (particulary in the patients with GO) than in other thyroid patients. Smoking among patients with thyroid disease (GO and GB disease) is associated with developing of anxiety and fright, depression and problems with social relations sphere.

Adolescent↗

PubMed2005

[Tobacco smoking in patients with multiple sclerosis--preliminary study].

Muliple sclerosis (MS) is a chronic disorder of autoimmune origin, affecting young people. The aim of our study was to evaluate the tobacco smoking in the patients with MS in the period of beginning the disease. The study included 58 MS patients (31 females, 27 males, mean +/- SD: age 32.15 +/- 6.28) with varying degrees of severity and types of MS (A. RRMS relapsing- remitting MS, B. SPMS - secondary-progressive MS and C. PPMS primary - progressive MS). Smoking status was determined by medical history and Fagerström test. In the examined group 38 (65.51%) persons were tobacco smokers, among them 21 (55.26%) females and 17 (44.74%) males. This preliminary analysis needs further thorough studies, f.e. the urine level of cotinine - as a main marker of tobacco smoking in MS patients.

Adult↗

PubMed2005

[Urinary cotinine in patients with hyperthyroidism].

The aim of our study was an analysis of cotynine, the main nicotine metabolite in the urine among hyperthyroid patients. The study group included 39 females and 4 males. The mean age was 35.59+/-14.22 yrs. (range: 18-73 yrs.; median: 32 yrs) among hyperthyroid patients suffering from: Graves-Basedow disease (GB), Graves' Ophtalmopathy (GO) and toxic nodular goiter (TNG). To evaluate the nicotine smoking intensity and ETS Environmental Tobacco Smoke, the urine analysis of cotynine level were performed. According to the statistical analysis using the Mann-Whitney test, the statistically significant difference between the level of cotynine among smokers suffering from GO and Graves-Basedow disease was revealed (p = 0.03). Similar results were obtained among the GO and TNG (p=0.02) using t-Student test with Welsch correction. To compare, there was no stastistically significant difference between the GB and TNG series (p=0.4). In the group of smoking patients with GO we found out incresed level of urine cotinine than in smoking patients with GB and TNG. We didn't found differences between GB and TNG in depends on an urine analysis of cotynine level.

Adolescent↗

PubMed2004

[Quality of life in Graves' ophthalmopathy (continuation of research)].

The previous research concerning "quality of life" in Graves patients with ophthalmopathy appeared to be a very important direction in health promotion. This drives us to continue enhancement of the quality of life in this group. The biggest deficiency we found to be in the life sphere activity and professional activity, interpersonal relations and positive self-estimation. We analyzed 48 women with Graves' Ophthalmopathy from 32 to 64 yr., average 43 SD 8,17. We used the following experimental methods: Quality of Life Experimental Inventory, Temperament Inventory (Eas-D). In Addition for Adults, STAI Questionnaire (State-Trait Anxiety Inventory) and Beck's Depression Scale. We interpreted obtained results as: 1. anxiety tendency, 2. subjective decreased mood, 3. decreased social contact tendency.

Adult↗

PubMed2004

[Smoking among thyroid patients].

UNLABELLED: The effects of cigarette smoking on the thyroid disease (Graves disease, toxic nodular goiter, toxic adenoma) have been studied for years. However, the effect of smoking on thyroid function is still controversial. OBJECTIVES: To determine the impact of cigarette smoking on the development of above-mentioned thyroid disease. PATIENTS METHODS: Study of 405 individuals with different thyroid disease. Information on thyroid disease and smoking habits was gathered by Fagerström questionnaire, and the patients' endocrinologist or general practitioner verified the diagnosis. RESULTS: The effect of smoking was more pronounced in Graves' patients than in other thyroid patients. We found out significant number of patients with toxic nodular goiter. CONCLUSIONS: Smoking is associated with an developing clinically thyroid disease--especially Graves disease. We also suggest the connection between psychological traits and smoking in this group of patients, corresponding with our previous examinations.

Female↗

PubMed2004

[High level of hsCRP in patients with Graves' ophthalmopathy--preliminary study].

UNLABELLED: C-Reactive Protein (CRP) levels are used to indicate the presence of an inflammatory process that may be caused by bacterial infection or pathological processes. The objective of this study was to compare the levels of CRP and hsCRP (high sensitivity CRP) in smoking and non smoking patients with Graves' Ophthalmopathy (GO). Study included 59 hyperthyroid patients (age > 18 years, 50 females, 9 males, mean +/- SD: age 34 +/- 16) with varying degrees of severity of GO (classification according to NOSPECS) with hyperthyroidism prepared to radioiodine therapy. Smoking status was determined by Fagerström test and Brinkman's index. CONCLUSIONS: 1. Smoking additionally stimulates inflammatory processes in the patients with Graves' Ophthalmopathy, 2. Smoking patients with

Adult↗

PubMed2002

A study of thyroglobulin concentration in the thyroid and serum of patients with different thyroid disorders.

Knowledge concerning the structure and quality of thyroglobulin (Tg) has great significance for the better understanding of the pathogenesis of different thyroid diseases. The localization of the Tg gene and studies of its structure by molecular biological techniques make possible precise investigations of its expression. The aim of our study was to evaluate Tg content in the thyroids and Tg concentrations in the serum of 108 patients suffering from benign or malignant thyroid disorders. The method of investigation was isolating total protein from thyroid tissues obtained during surgery and determining Tg content in the thyroid extracts and Tg concentrations in serum. The Tg concentrations in serum and in thyroid protein extracts were evaluated by fluoroimmunometric assay. Statistical analysis was carried out with the help of the computing programmes.

Adolescent↗