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Biomedical subjects

Agathe Laurent

Publications and source records attributed to Agathe Laurent.

3 recordsLinked to original sources

Nonidiopathic focal epilepsies: methodological problems for a comprehensive neuropsychological evaluation.

In aiming to define better practice parameters for neuropsychological assessment in patients with nonidiopathic partial epilepsies, particularly in children, we discuss the reasons for the current lack of clear answers. The relevant factors include the epilepsy itself, the complexity of the issues related to cognitive function/dysfunction and the underlying developmental processes. Another factor is the lack of availability and high cost of neuropsychological testing, even in industrialized societies. Because of these factors, the need for neuropsychological testing must be considered on an individual basis in the initial evaluation of every child with focal epilepsy; it should be left to the clinician and parents to decide which children will actually be referred. Systematic presurgical and postsurgical testing is important for surgical candidates. Comprehensive research protocols should be designed on a collaborative basis between large epilepsy centers, covering all the essential parameters to be evaluated. Children with focal epilepsies should be included in these protocols from the onset of the epilepsy.

Adult↗

Cognitive impairments in children with nonidiopathic temporal lobe epilepsy.

Ictal and interictal activities occurring in a mature brain can disorganize the neural network activity involved in one or various specific cognitive processes. In children, the situation might be more complex: the epileptic process occurs in a period when the cortex is still maturing and it may interfere with normal cerebral development. Although neural plasticity in children is greater than it is in adults, greater plasticity does not necessarily mean adaptive plasticity. Studies have shown that temporal lobe epilepsy in children is not systematically associated with global mental retardation. However, various difficulties in specific cognitive domains are more often found in children than in patients with adult-onset epilepsy. Language, memory, socioperceptive competence, and also executive functions, which can be impaired by the disruption of the temporofrontal circuit, are among such cognitive functions that need to be evaluated. Early detection of specific deficits is of primary importance for the implementation of appropriate remediation measures.

Age Factors↗

Early brain lesions and face-processing development.

Studies of functional plasticity after pre- or perinatal brain damage can tell us whether the neural substrate normally involved in the development of a given ability is specific and, if so, when it becomes functionally specified and unique. Development of face processing was investigated in 5- to 17-year-old children who had a unilateral brain injury in the pre-, peri-, or postnatal period. In Studies 1 and 2, patients with a posterior injury involving the temporal regions exhibited a face-processing deficit that was independent of their age at test time. Even though differences were observed between the two hemispheres in face processing during infancy as well as in adults in cases of normal development, no clear differences between right and left injury were observed here in face-processing deficit. Poor postlesional face-processing plasticity seems to contrast with results of several studies on speech development after early unilateral injury. If the difference in the time window for postlesional plasticity between these two areas of competency is confirmed, it would suggest that the two kinds of abilities rely on neural cells which are sensitive to different plasticity factors.

Adolescent↗