Degloving injury of pelvis treated by internal fixation and omental flap reconstruction.
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Adult↗
Biomedical subjects
Ahmet Alponat
Publications and source records attributed to Ahmet Alponat.
Is minisite cholecystectomy less traumatic? Prospective randomized study comparing minisite and conventional laparoscopic cholecystectomies.
The main objectives of minisite cholecystectomy (MC) are to have smaller incisions, better cosmetic results, less trauma, and a lower morbidity rate. This prospective randomized study compares MC with conventional laparoscopic cholecystectomy (CLC) in terms of surgical trauma and cosmetic results in 44 patients. Conversion from MC to CLC was required in five patients. No conversion to open surgery was needed in the CLC group. The average operating time was slightly longer in the MC group, but the difference was not statistically significant (81 minutes versus 72 minutes, p = 0.22). The population characteristics, postoperative respiratory function measurements, pain scores, and analgesic requirements were similar in the two groups. The average score for scar tissue was significantly lower in the MC group (0.73 versus 1.93, p = 0.0045). Only the cosmetic results of MC were superior to CLC. This technique could be a feasible alternative procedure in patients seeking better cosmetic results. However, further studies with larger sample sizes are needed to evaluate the postoperative morbidity of MC.
Adult↗
Mitomycin-C prevents reformation of intra-abdominal adhesions after adhesiolysis.
BACKGROUND: Prevention of adhesions is central to surgical practice, because they cause significant morbidity. Inhibition of fibroblast proliferation is a way to prevent adhesions. Mitomycin-C (MMC) (Kyowa-Hakko-Kogyo Co, Ltd, Tokyo, Japan) is an alkylating agent that also inhibits fibroblast proliferation for up to a few weeks. We investigated the effect of MMC on the prevention of adhesion reformation. METHODS: Adhesions were generated by brushing the cecum and parietal peritoneum in 60 female Wistar albino rats. Ten days later, during a second laparotomy, adhesions were graded. After adhesiolysis, rats were divided into 3 groups. Group 1 was intraperitoneally administered 5 mL of saline solution, whereas groups 2 and 3 were intraperitoneally administered 0.5 mg/kg MMC in 5 mL of saline solution. MMC solution in the abdomen was completely rinsed and aspirated after 5 minutes in group 2 and after 10 minutes in group 3. Then, all the rats were administered 5 mL of saline solution intraperitoneally. After 10 days, adhesions were graded again during a third laparotomy. RESULTS: Both MMC groups had significantly lower adhesion scores compared with the control group (P <.001). No side effects from MMC were observed during the experiment. CONCLUSIONS: MMC was found to be very effective in preventing adhesion reformation.
Alkylating Agents↗