Biomedical subjects

Ajay B Satpute

Publications and source records attributed to Ajay B Satpute.

5 recordsLinked to original sources

PubMed2006

Integrating automatic and controlled processes into neurocognitive models of social cognition.

Interest in the neural systems underlying social perception has expanded tremendously over the past few decades. However, gaps between behavioral literatures in social perception and neuroscience are still abundant. In this article, we apply the concept of dual-process models to neural systems in an effort to bridge the gap between many of these behavioral studies and neural systems underlying social perception. We describe and provide support for a neural division between reflexive and reflective systems. Reflexive systems correspond to automatic processes and include the amygdala, basal ganglia, ventromedial prefrontal cortex, dorsal anterior cingulate cortex, and lateral temporal cortex. Reflective systems correspond to controlled processes and include lateral prefrontal cortex, posterior parietal cortex, medial prefrontal cortex, rostral anterior cingulate cortex, and the hippocampus and surrounding medial temporal lobe region. This framework is considered to be a working model rather than a finished product. Finally, the utility of this model and its application to other social cognitive domains such as Theory of Mind are discussed.

Animals↗

PubMed2005

Context processing and context maintenance in healthy aging and early stage dementia of the Alzheimer's type.

Declines in the ability to process context information may represent a fundamental mechanism of age-related cognitive changes. Two components of context processing--activation/updating and maintenance--were examined in a sample of healthy younger and older adults, along with individuals suffering from early stage dementia of the Alzheimer's type (DAT). All older adult groups showed context activation/updating impairments, whereas context maintenance was only impaired in the oldest adults (age>75 years) and was further exacerbated in DAT individuals. The results suggest that context processing may be composed of functionally dissociable components and point to the utility of this construct in understanding the timecourse of cognitive decline in healthy and pathological aging.

Adolescent↗

PubMed2005

An fMRI study of causal judgments.

The capacity to evaluate causal relations is fundamental to human cognition, and yet little is known of its neurocognitive underpinnings. A functional magnetic resonance imaging study was performed to investigate an hypothesized dissociation between the use of semantic knowledge to evaluate specifically causal relations in contrast to general associative relations. Identical pairs of words were judged for causal or associative relations in different blocks of trials. Causal judgments, beyond associative judgments, generated distinct activation in left dorsolateral prefrontal cortex and right pre-cuneus. These findings indicate that the evaluation of causal relations in semantic memory involves additional neural mechanisms relative to those required to evaluate associative relations.

Adolescent↗

PubMed2005

Personality from a controlled processing perspective: an fMRI study of neuroticism, extraversion, and self-consciousness.

Although neuroticism has been central to most theories of personality, self-reported neuroticism has had limited success in predicting expected behavioral outcomes. The reason for this may be due, in part, to the imprecision of self-reports. The purpose of this study was to examine the relationship between neural correlates of control systems and neuroticism, extraversion, and self-consciousness. In response to an oddball task, neuroticism was associated with increased dorsal anterior cingulate cortex (dACC) reactivity, typically associated with discrepancy detection, whereas extraversion and self-consciousness were associated with lateral and medial frontoparietal networks, respectively, typically associated with task-focused (lateral) or self-focused (medial) controlled processes. We also examined whether the neural measure of neuroticism would predict a relevant behavioral outcome better than self-reports would. Interoceptive accuracy, an outcome associated with neuroticism, was better accounted for by dACC reactivity (r2 = .74) than by self-reported neuroticism (r2 = .16), suggesting that neural reactivities may provide a more direct measure of personality than self-reports do.

Adult↗

PubMed2004

Evidence-based and intuition-based self-knowledge: an FMRI study.

Behavioral and neuropsychological studies have suggested multiple self-knowledge systems may exist (i.e., evidence-based and intuition-based self-knowledge); however, little is known about the nature of intuition-based self-knowledge. In a functional magnetic resonance imaging study, the neural correlates of intuition-based and evidence-based self-knowledge were investigated. Participants with high and low experience in different domains (soccer and acting) made self-descriptiveness judgments about words from each domain while being scanned. High-experience domain judgments produced activation in a network of neural structures called the X-system, involved in automatic social cognition, whereas low-experience domain judgments produced activations in a network called the C-system, involved in effortful social cognition and propositional thought. The affective and slow-changing nature of intuition-based self-knowledge is discussed.

Adult↗