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Akihiko Yoshizawa

Publications and source records attributed to Akihiko Yoshizawa.

8 recordsLinked to original sources
PubMed2026

Pathology-Driven Diagnosis of Hereditary Leiomyomatosis and Renal Cell Carcinoma: A Clinicopathological and Genetic Analysis of Three Cases.

INTRODUCTION: Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is an autosomal dominant disorder characterized by three principal clinical features: cutaneous leiomyomas (cLMs), uterine leiomyomas, and fumarate hydratase (FH)-deficient renal cell carcinoma (RCC). Although 200-300 families have been identified worldwide, its true prevalence remains unknown. CASE PRESENTATIONS: We present three HLRCC cases in which detailed pathological examination raised initial clinical suspicion. Cases 1 and 2 presented with advanced RCC exhibiting diverse morphologies. Case 3 presented with multiple painful cLMs and no renal tumors. All three cases were confirmed via germline genetic testing, which revealed distinct FH mutations. CONCLUSIONS: These cases underscore the importance of careful histopathological and immunohistochemical evaluation for the diagnosis of HLRCC. Multidisciplinary discussion integrating clinical, radiological, pathological, and genetic findings is essential for identifying affected families and initiating timely surveillance.

cutaneous leiomyoma↗
PubMed2006

The specific antibody to Brachyspira aalborgi in serum obtained from a patient with intestinal spirochetosis.

Serum obtained from a patient histopathologically diagnosed as intestinal spirochetosis was investigated serodiagnostically by agglutination test. B. aalborgi which is a human intestinal spirochete reacted strongly with the human serum, while B. pilosicoli which has potential pathogenicity to humans reacted with the serum, but as strongly and its titer was different than the other three species. On the other hand, intestinal spirochetes (Matsumoto isolates) were isolated from the biopsy samples of the patient. The morphological, biochemical, and genetic characteristics of the isolates were very similar to those of B. aalborgi. Furthermore, the protein profiles of the Matsumoto isolates were also similar to those of B. aalborgi but were different than those of B. pilosicoli and B. hyodysenteriae. The reaction profiles of the Matsumoto isolates in immunoblotting were relatively similar to those of B. aalborgi except for a 74 kDa band but were different from those of B. pilosicoli and B. hyodysenteriae. Therefore, we identified the Matsumoto isolates as B. aalborgi and diagnosed the patient with a B. aalborgi infection.

Agglutination Tests↗
PubMed2003

Malignant peripheral nerve sheath tumor of the parotid gland.

Malignant peripheral nerve sheath tumor (MPNST) has been defined as any malignant tumor arising from or differentiating toward cells of the peripheral nerve sheath. We treated a case of MPNST arising from the right parotid gland that showed a highly aggressive course. We reviewed the English-language literature published since 1990 and found 142 cases of head and neck MPNST reported within the past 13 years. The results of the review suggested that MPNSTs may arise from any organs of the head and neck. Immunohistochemical analysis of various neural markers plays a significant role in the evaluation of the histologic diagnosis. Curative treatment based on radical resection of MPNSTs of head and neck origin is more difficult than treatment of MPNSTs of other origins.

Humans↗
PubMed2002

Alveolar shrinkage in bronchioloalveolar carcinoma without central fibrosis.

Preservation of alveolar architecture in small bronchioloalveolar carcinoma (BAC) is one of the most important factors for predicting their prognosis, alveolar shrinkage in BAC, however, has not been studied well. In ten cases of pure BAC without collapse or central fibrosis, we measured two two-dimensional (2D) parameters; side-length of the alveoli facing alveolar ducts and circumference of the alveoli forming complete circles. And we also examined three-dimensionally (3D) elastic fibers and myofibroblasts in the thick sections. In BAC, 2D parameters showed alveolar shrinkage. The elastic fibers forming the alveolar framework, including the alveolar orifice, were 3D sinuous and bent in BAC, and suggested that alveolar shrinkage cased by folding of the alveolar wall. Myofibroblasts lay transversely and longitudinally in the interstitium in BAC, intertwined with the elastic fibers. Proliferation of myofibroblasts may be of importance in alveolar wall-folding and alveolar shrinkage in BAC.

Adenocarcinoma, Bronchiolo-Alveolar↗