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Biomedical subjects

Akio Kosaka

Publications and source records attributed to Akio Kosaka.

3 recordsLinked to original sources

A deformable model for automatic CT liver extraction.

RATIONALE AND OBJECTIVES: This study was performed to design an automatic liver region extraction system to facilitate clinical liver size estimation and further serve as a prestage for liver reconstruction and volume estimation. MATERIALS AND METHODS: We present a modification of the well-known snakes algorithm for extracting liver regions in noisy CT images. Our modification addresses the issues of selection of the control points on an estimate of the contour and the determination of the weighting coefficients. The weighting coefficients are determined dynamically on the basis of the distance between the control points and the local curvature of the contour. RESULTS: The proposed method was used in extracting liver regions from 98 cross-sectional abdominal images. The overall performance was estimated by comparisons with original liver regions. CONCLUSION: The deformable model method enables an efficient and effective automatic liver region extraction in noisy environments. This approach eliminates human-in-the loop, which is the common practice for the majority of current methods.

Algorithms↗

Image-guided neurosurgery system integrating AR-based navigation and open-MRI monitoring.

As endoscopic surgery has become a popular form of minimally invasive surgery, it increasingly requires useful imaging tools to help the surgeons perform safe and secure operations. Our navigation system provides surgeons with visual information by overlaying 3D wire frame models of tumor onto live images, as well as by displaying relative the positions of surgical tools and the target tumor. Such 3D wire frame models are generated from pre-operative CT/MR images with the help of a 3D surgical simulation software. Another important function of our system is real-time volume rendering of intra-operative MR images for the target tumor. This function allows surgeons to carefully observe the vicinity of the tumor regions to be removed, by rendering the sectional views with respect to the surgical tool position, so that surgical performance can be easily monitored during the operation. We tested this navigation system in more than 10 clinical operations and verified the effectiveness of the navigation and surgical performance.

Brain Diseases↗

[Significance of tissue PyNPase, TS, and DPD activities in breast cancer].

We analyzed the interim results of prognostic significance of pyrimidine nucleoside phosphorylase (PyNPase), thymidylate synthase (TS), and dihydropyrimidine dehydrogenase (DPD) in 5-FU-based chemotherapy for breast cancer. In surgical specimens of tumor tissues and normal mammary gland tissues from 102 breast cancer patients, TS, PyNPase, and DPD activities were measured, and p53 and c-erbB-2 overexpression were also examined. TS, d-Thd-Pase/Urd-Pase (PyNPase), and DPD activities were significantly higher in tumor tissues than in normal tissues. There was a strong correlation between d-Thd-Pase and Urd-Pase in tumor tissues. No relationship was found between patient characteristics and any of the enzyme activities. PyNPase activities were significantly higher in the tissues having a c-erbB-2 overexpression of 75% (4+) or more than in those having less than 75%, and the tissues with a p53 of 50% (3+) or more had significantly higher TS activities than those with less than 50%. However, the other parameters showed no significant difference. The data obtained so far suggest no clear correlation between the activity of any of these enzymes and prognosis.

Adult↗