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Biomedical subjects

Akira Takeda

Publications and source records attributed to Akira Takeda.

25 records · Page 2Linked to original sources
PubMed2002

[Effect of tonometry on a glaucoma population study].

PURPOSE: The purpose of this study was to evaluate the influence of tonometry in detecting the occurrence of glaucoma. METHODS: The subjects, 845 out of 3,488 residents aged 40 years or older, were examined according to standard protocols, including tonometry, slit lamp examination, fundus photography, and automatic perimetry as a recall examination. The intraocular pressure in each subject was measured by both Goldmann applanation tonometer(GAT) and noncontact tonometer CT-70 (NCT). RESULTS: The mean +/- standard deviation intraocular pressure measured by GAT was 15.52 +/- 2.57 mmHg, and 15.03 +/- 2.90 mmHg by NCT. There was a statistically significant correlation(p < 0.0001). The difference between pairs of measurements by GAT and NCT was 0.50 +/- 1.93 mmHg. There was no influence of tonometry in detecting the incidence of glaucoma, which was 4.14%; primary open-angle glaucoma 0.59%, normal tension glaucoma 2.6%, primary angle-closure glaucoma 0.47%, and other types of glaucoma 0.48%. The detection of ocular hypertension was different, and was 2.13% with GAT and 2.72% with NCT. CONCLUSION: In our study, the influence of tonometry in detecting the incidence of glaucoma was very small. A noncontact tonometer is considered to be useful for glaucoma population study.

Adult↗
PubMed2002

[Recent progress of radiology in rheumatoid arthritis: a role of magnetic resonance imaging].

Since MR imaging directly visualizes all articular components with excellent contrast resolution, it allows the joint to be viewed as a whole organ. An increasing aggressive therapeutic strategy has attracted growing attention to the potentials of MR imaging in the diagnosis, prognostication, and outcome measure of RA. The introduction of MR imaging into the diagnostic criteria for early RA contributes to more accurate diagnosis in patients suspected of having RA and thus allow an earlier decision to start proper medication. Quantification of inflammatory synovitis by MR imaging can assess treatment outcome in fewer subjects than with traditional measures. We believe MR imaging can be cost-effectively incorporated in the treatment trial.

Adult↗
PubMedDate not supplied

Fingertip reconstruction by nail bed grafting using thenar flap.

Ideally, treatment for fingertip injury should involve the least pain possible, using durable and sensate skin with due consideration to aesthetic aspects. This paper presents two cases of fingertip reconstruction through the use of thenar flaps and nail bed grafts. In either case, injury had been due to fingertip crushing and reconstruction was conducted immediately thereafter. A full-thickness nail bed with hyponychium and perionychium from the severed part was used for dorsal reconstruction and thenar flaps for finger pulp reconstruction. In both cases, the grafting was quite satisfactory and good soft-tissue healing was observed. Subsequent nail growth and adherence were good. The outcome was pleasing to both patients. Thus, the presented method may be considered quite satisfactory from aesthetic and functional recovery standpoints.

Amputation, Traumatic↗
PubMedDate not supplied

Wound healing in denervated rat skin.

Recently, several reports have suggested that innervation influences wound healing. However, some investigators have reported that nerve injury prevented wound healing while others have suggested it had no influence on full-thickness skin wound healing. We created denervated skin areas on rats by dissection of the spinal hemicord. Subsequently, 15-mm-diameter skin defects were made symmetrically within the denervated area on the right side of the back and the normal innervated area on the left side. Biopsies were performed at 3, 7, and 14 days after wounding. We measured changes of the wound surface area, the rate of wound contraction, and the rate of epithelialization. The differences were not significant at 3 or 7 days after the operation. However, we could observe significantly delayed wound healing of the denervated skin areas compared to the normal areas at 14 days. Both wound contraction and epithelialization were delayed in the denervated groups. Our results suggest that sensory disturbance is a negative factor for skin wound healing.

Animals↗
PubMedDate not supplied

Inhibitory effects on pulmonary metastases of low-dose consecutive administration of cisplatin on sarcoma-bearing mice.

Low-dose consecutive CDDP administrations have been reported to be effective in cancer treatment. We studied the inhibitory effects on pulmonary metastasis of bolus versus low-dose consecutive administration of CDDP chemotherapy for sarcoma-bearing mice, and evaluated the differences in responses to two types of therapy. Significant reductions (p < 0.01) in the number of pulmonary metastases were observed in the low-dose consecutive administration group compared to the control group, and in the bolus group compared to the control group. No significant difference in the number of metastases between the low-dose consecutive administration group and the bolus group was observed (p = 0.43). This study suggests that low-dose consecutive CDDP administration would be as effective as bolus CDDP administration, which is currently popular. Also, low-dose consecutive CDDP administrations may contribute to the attenuation of the adverse drug reactions expected by patients with bone and soft tissue tumors who are undergoing chemotherapy.

Animals↗
PubMedDate not supplied

An experimental study on the therapeutic effect of consecutive low-dose cisplatin with caffeine in sarcoma-bearing mice.

UNLABELLED: The aims of this study were to investigate the anti-tumor effects of consecutive low-dose cisplatin (LD-CDDP) in comparison with single high-dose CDDP (HD-CDDP) in combination with caffeine. MATERIALS AND METHODS: Human fibrosarcoma cells (HT-1080) were transplanted in BALB/C-nu mice. According to the administration of CDDP and caffeine, 5 groups were defined: HD-CDDP, LD-CDDP, HD-CDDP +caffeine, LD-CDDP +caffeine and control group. The total dose of CDDP was 3.5 or 6 mg/kg. CDDP was injected i.p. bolus (HD-CDDP) or divided into 5 days (LD-CDDP). Caffeine was injected i.p. at a dose of 60 mg/kg twice a day for 4 days. RESULTS: Significant inhibition of tumor growth and prolongation of survival time were recognized in the HD- and LD-CDDP groups with and without caffeine compared to the control group. The caffeine-assisted groups had no advantage compared to the CDDP alone groups. CONCLUSION: The effects of LD-CDDP were similar to the effect of HD-CDDP.

Animals↗