Biomedical subjects

Albert W Leung

Publications and source records attributed to Albert W Leung.

3 recordsLinked to original sources

PubMed2006

Differential expression of proteins in kidney, eye, aorta, and serum of diabetic and non-diabetic rats.

Diabetes mellitus (DM) is a chronic progressive disease that often results in microvascular and macrovascular complications, yet its pathogenesis is not clear. Automated proteomic technology, coupled with powerful bioinformatics and statistical tools, can provide new insights into the molecular alterations implicated in DM. Following our previous findings of redox changes in the eye and aorta of diabetic rats, as well as the activities of different antioxidant enzymes during the development of DM, this study is further launched to find potential biomarkers by comparing the serum and tissue samples of 26 diabetic rats (8 weeks after streptozotocin [STZ] administration) with 29 normal controls using surface enhanced laser desorption/ionization time-of-flight mass spectrometry (SELDI-TOF MS) technology. Eight potential biomarkers were found in the serum, one potential biomarker was found in the kidney and eye, respectively, whereas three potential biomarkers were discovered in the aorta. One of the serum biomarker candidates was found to match the C-reactive protein (CRP) in the Swiss-Prot knowledgebase. Further validation has been conducted by ELISA kit to confirm the role of CRP during the development of DM. To conclude, the increased level of CRP in diabetic serum demonstrated in this study indicates that the development of DM is associated with inflammation. This is also the first report demonstrating that some potential lysate biomarkers in the kidney, eye, and aorta may be involved in the development of diabetes and its complications. Further identification and evaluation of these potential biomarkers will help unravel the underlying mechanisms of the disease.

Animals↗

PubMed2005

Implicit learning of ignored visual context.

Humans process a visual display more efficiently when they encounter it for a second time, showing learning of the display. This study tests whether implicit learning of complex visual contexts depends on attention. Subjects searched for a white target among black and white distractors. When the locations of the target and the attended set (white distractors) were repeated, search speed was enhanced, but when the locations of the target and the ignored set (black distractors) were repeated, search speed was unaffected. This suggests that the expression of learning depends on attention. However, during the transfer test, when the previously ignored set now was attended, it immediately facilitated performance. In contrast, when the previously attended set now was ignored, it no longer enhanced search speed. We conclude that the expression of visual implicit learning depends on attention but that latent learning of repeated information does not.

Adolescent↗

PubMed2003

Development of a marine subtidal epibiotic community in Hong Kong: implications for deployment of artificial reefs.

A 2-year study was conducted in Hong Kong to examine the effects of substratum, season and length of submersion on the development of a subtidal epibiotic community using four types of settlement panels (concrete, steel, wood and tyre). The season and length of submersion had a strong influence on the total biomass and on community structure while the type of substratum had very little impact on the total biomass or the structure of the epibiotic community. The season of submersion determined the species composition of the newly submerged surfaces. In the spring and summer, tubeworms were the most abundant. In the autumn and winter, barnacles and tunicates dominated. Community succession was not obvious in the first year of submersion as it was intermingled with strong seasonal settlement, growth and death of barnacles and tunicates. In the second year of submersion, green mussels and tunicates settled and grew to occupy most of the panel surfaces, forming an assemblage that was characteristic of climax communities in the local subtidal waters. The results suggest that the type of construction material has limited impact on the development of epibiotic communities on artificial reefs deployed in Hong Kong; the season of submersion may affect community structure in the early successional stage, but not the characteristics of the climax communities. This study indicates that the type of substratum should not be of concern when deploying artificial reefs in the subtidal waters in this region. The design of artificial reefs should focus more on other physical and economical aspects such as durability, flow dynamics, stability, cost, and effects on the ambient environment.

Analysis of Variance↗