Biomedical subjects

Alessio Buonfigli

Publications and source records attributed to Alessio Buonfigli.

2 recordsLinked to original sources

PubMedDate not supplied

The influence of the ionic medium on the behaviour of sodium glycocholate and cholate aqueous solutions.

In the framework of research on the sodium bile salts, solutions of sodium cholate and glycocholate had been studied only at three ionic medium concentrations. In this paper, experiments in two other concentrations of ionic medium are carried out both to verify the behaviour dependence on the ionic medium and to apply the results of this paper to a future investigation on solutions containing contemporary sodium cholate and glycocholate. To this aim, solubility, protonation constants, lead (II) salts solubility products at 25 degrees C and in 0.300 and 0.750 mol dm(-3) N(CH3)4Cl were determined. The formed species in solutions containing lead (II) together with the selected bile salts and the behaviour of the sodium salts in micellar and premicellar solutions were investigated, too. The obtained results were compared with those obtained at the other ionic medium concentrations.

Glycocholic Acid↗

PubMedDate not supplied

Composition of sodium cholate micellar solutions.

To study the composition of sodium cholate solutions, an investigation was carried out at 25 degrees C and in N(CH3)4Cl, as a constant ionic medium, at three different concentrations (W = 0.100; 0.500 and 0.800 mol dm(-3)). Electromotive force measurements of three different galvanic cells, the first involving a glass electrode for hydrogen ions, the second an electrode for sodium ions and the third a lead amalgam electrode, were performed. Independently, lead (II) cholate solubility measurements in the presence of sodium ions were performed, as well. The experimental results obtained from both approaches were explained by assuming the formation of aggregates in cholate and sodium of different composition depending on W and on the cholate concentration. The maximum aggregation found number for cholate was 24 and even aggregation numbers were markedly predominant. Only two species with odd aggregation number were found, but at a low percentage. The assumed species and the relative constants were compared with those found for the other sodium salt of cholanic acids.

Cholic Acids↗