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Biomedical subjects

Alex Stagnaro-Green

Publications and source records attributed to Alex Stagnaro-Green.

7 recordsLinked to original sources

The thyroid and pregnancy: a novel risk factor for very preterm delivery.

The major cause of neonatal mortality and morbidity is preterm delivery in general (< 37 completed weeks), and especially very preterm delivery (< 32 completed weeks). The objective of this study is to determine if either thyroid hormonal dysfunction and/or the presence of thyroid autoantibodies in the mother are associated with an increased risk of preterm and/or very preterm delivery. Data were collected prospectively and analyzed as a nested-case control study. There were 953 delivered gravidas enrolled between 1996 and 2002. Samples were collected at entry to care and stored at -70 degrees C. Cases included all women with preterm delivery (n = 124). Controls (n = 124) were randomly selected from among the 829 women who delivered at term (> 37 completed weeks). All samples were assessed for thyroid stimulating hormone, thyroperoxidase antibody, and thyroglobulin antibody. Gravidas with high thyrotropin (TSH) levels had a greater than threefold increase in risk of very preterm delivery. In some analyses, gravidas who tested positive for thyroglobulin antibody at entry to prenatal care also had a better than twofold increased risk of very preterm delivery. There were no significant associations between TSH level or thyroglobulin antibody positivity and the risk of moderately preterm delivery.

Adult↗

Thyroid autoimmunity and the risk of miscarriage.

Approximately one-third of all pregnancies end in miscarriage. The etiology of recurrent abortion remains unknown in approximately 50% of all women. In the early 1990s it was discovered that unselected euthyroid women who present with thyroid antibodies (thyroid peroxidase and thyroglobulin) in the first trimester of pregnancy have a two-four-fold increase in their miscarriage rates. The majority of studies investigating women with recurrent abortion have also found a significant increase in thyroid antibody positivity compared with controls. Although the etiology of miscarriage in thyroid antibody women remains unknown, recent data have revealed a potential direct effect of thyroglobulin antibodies on pregnancy loss in a murine model. Uncontrolled studies assessing the effect of levothyroxine on decreasing the miscarriage rate in euthyroid antibody positive women, have demonstrated a decreased miscarriage rate.

Abortion, Spontaneous↗

Postpartum thyroiditis.

Postpartum thyroiditis (PPT) is the occurrence, in the postpartum period, of transient hyperthyroidism and/or transient hypothyroidism, with most women returning to the euthyroid state by 1 year postpartum. The prevalence of PPT varies from 1.1 to 16.7%, with a mean prevalence of 7.5%. Women with type I diabetes mellitus have a three-fold increase in the prevalence of PPT. PPT is an autoimmune disorder which is a transient form of Hashimoto's thyroiditis occurring postpartum as a consequence of the immunologic flare following the immune suppression of pregnancy. Women experience symptoms in both the hyperthyroid and hypothyroid phase, but the association between PPT and postpartum depression remains undefined. Approximately 25% of women with a history of PPT will develop permanent hypothyroidism in the ensuing 10 years. Treatment for the hyperthyroid phase, when required, is a short dose of beta-blockers. Women with a TSH greater than 10 mU/l, or between 4 and 10 mU/l with symptoms or attempting pregnancy, require thyroid hormone replacement. Whether or not to screen for PPT remains controversial.

Female↗

Applying adult learning principles to medical education in the United States.

An extensive literature on adult learning principles has been developed over the last 40 years. Simultaneously, undergraduate medical educational programs have undergone varying degrees of curricular reform. The present paper discusses the educational and societal factors that have functioned as a catalyst for innovations in medical education, and reviews the major initiatives which have been undertaken. Data are analyzed to assess the extent to which some of these changes have been incorporated into medical curricula. A comprehensive review of adult learning principles is than presented, in order to provide a framework for the incorporation of principles of adult learning into the next wave of medical education reform. The review of adult learning principles reveals that undergraduate medical educational reform has underutilized the robust literature on adult learning. The present paper concludes with suggestions for medical education reform that incorporates the principles of adult learning and discusses the major impediment to curricular reform.

Adult↗

Translational medicine in the first year: integrative cores.

OBJECTIVE: The intensity of the first year leaves many students pondering the wisdom of their career choice. In creating its new curriculum, Mount Sinai School of Medicine faced this issue of burnout by devoting the last three weeks of the first year to a course that links basic science concepts introduced at the bench to the clinical care of patients. The goal of "Bench to Bedside Selectives" is to reenergize students' career choice by allowing them to experience a multidisciplinary approach to translational medicine. Students participate in an in-depth study of a selected disease entity under the direction of a faculty core leader. DESCRIPTION: In 2001, students selected either a research core (n = 57), which allowed them to expand their summer research time, or a disease-focused core (n = 48). Six diseasefocused cores were offered, each consisting of didactic sessions, exposure to basic research, diagnostic laboratory techniques, ethics, health policy, pharmacology, and clinical experiences. The cores were as follows: (1) Atherosclerotic Heart Disease: Integration of Basic Science and Clinical Medicine; (2) Translational Medicine in HIV: A Road to a Cure; (3) Gene Therapy: A Journey from Scientific Principles to Clinical Applications; (4) Solid Organ Transplantation: Defying Mother Nature; (5) The ABC's of Liver Disease; (6) The New Frontiers in Aging. Core leaders were responsible for developing and implementing their programs and recruiting faculty from many departments. All students completed an independent project tailored to their core. For example, the HIV core included modules on AIDS in Africa and needle-exchange programs, and the students' final project was a debate on whether "there will or will not be an effective HIV vaccine in the next 5 years." Students ranked their top three choices among the cores. Most (96%) were enrolled in their first or second choices, forming groups of six to eight. On the last day of core, students attended a focus group and filled out questionnaires about the strengths and weaknesses of their experience. DISCUSSION: There was overwhelming support for the core experience at the focus session. Most students commented that the program successfully overcame their end-of-first-year blues. All students felt that cores should be continued and recommended additional core selections. Weaknesses cited were inequality in the time and amount of work required for individual cores and an imbalance between excessive didactic material and insufficient clinical exposure in one core. Seventy-one percent of participants also completed the feedback questionnaires; 97% of them strongly agreed that the core successfully integrated material from previous courses; 88% strongly agreed that the clinical presentations demonstrated the relevance of content to medical practice; and 69% strongly agreed that the proportionate mix of lab, clinical, and small-group sessions was appropriate. Faculty were also enthusiastic about their experience. This program will be continued and expanded in 2002. We recommend this teaching format as an antidote to first-year burnout and a novel way to promote the development of physicians with an appreciation of the scientific basis of disease and the role ethics and health policy play in medicine.

Attitude of Health Personnel↗