Biomedical subjects

Alexander Brawanski

Publications and source records attributed to Alexander Brawanski.

21 records · Page 2Linked to original sources

PubMed2002

Does bungee jumping release S-100B protein?

The S-100B protein is a recognised indicator of traumatic brain damage, but the impact threshold at which S-100B is released into serum still remains unknown. The aim of the study was to investigate whether moderate shear forces are able to release S-100B into serum in people who did a bungee jump. Eleven healthy probands jumped from a height of 50 microm and were exposed to an acceleration of about 2.8 g. Blood samples were drawn before the jump, immediately after and 71 min (mean) after the jump. The initial serum values of S-100B of all probands were normal (mean 0.22 microg/l). Also the serum values directly after and 71-min (mean) after the jump showed no increase of S-100B (0.22 microg/l and 0.23 microg/l, mean). This finding indicates that a moderate acceleration and deceleration force to the brain does not activate the release of the protein S-100B into the serum.

Acceleration↗

PubMed2002

Pain resolution after lumbar disc surgery is influenced by macrophage tissue infiltration. A prospective consecutive study on 177 patients.

The aim of this study was to assess the influence of inflammatory reactions in herniated lumbar disc specimens on pain resolution after lumbar disc surgery. Disc specimens of 200 patients who underwent surgery for lumbar disc herniation were studied immunohistologically. Preoperatively each patient received a verbal rating scale (VRS) for classification of the pain level and general clinical data were recorded prospectively. Varying amounts of macrophages could be demonstrated. Eighty-nine percent of patients could be followed up for a mean period of 7 months. A statistically significant correlation between the histologically observed macrophage infiltration and postoperative pain grading according to the VRS was found. Patients with evidence of inflammatory reactions rated their postoperative complaints lower than patients with no evidence of inflammatory reactions on the VRS (P = 0.04). In our study, a statistically significant correlation between inflammatory changes in the herniated lumbar disc specimen and outcome after lumbar disc surgery could be demonstrated.

Adult↗

PubMed2002

Comparison of near-infrared spectroscopy and tissue p(O2) time series in patients after severe head injury and aneurysmal subarachnoid hemorrhage.

Monitoring of local oxygen pressure in brain white matter (tip(O2)) and of local hemoglobin oxygen saturation (rS(O2)) with near-infrared spectroscopy (NIRS) are increasingly employed techniques in neurosurgical intensive care units. Using frequency-based mathematical methods, the authors sought to ascertain whether both techniques contained similar information. Twelve patients treated in the intensive care unit were included (subarachnoid hemorrhage, n = 3; traumatic brain injury, n = 9). A tip(O2) probe and an NIRS sensor were positioned over the frontal lobe with the most pathologic changes on initial computed tomography scan. The authors calculated coherence of tip(O2) and rS(O2) ts overall density distribution, its distribution per data set, and its time evolution. The authors identified a band of significantly correlated frequencies (from 0 to 1.3 x 10(3) Hz) in more than 90% of the data sets for coherence and overall density distribution. Time evolution showed slow but marked changes of significant coherence. By means of spectral analysis the authors show that tip(O2) and rS(O2)signals contain similar information, albeit using completely different registration methodologies.

Adolescent↗