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Alexei G Titov

Publications and source records attributed to Alexei G Titov.

2 recordsLinked to original sources
PubMed2004

Arthroscopic operations in joint tuberculosis.

We assessed the usefulness of arthroscopy in bone and joint tuberculosis (11 knees, 1 elbow and 1 ankle). In all 11 patients with knee joint involvement the arthroscopic operation were successful with a significant improvement in the range of motion (P=0.007) and knee score (P=0.003). There were no cases of reactivation or recurrence during a follow-up period of 15-42 months. In contrast, in the two patients with ankle or elbow joint involvement and bone destruction, arthroscopy had to be converted to open operation. Minor trauma, a short hospitalization time and a short post-operative rehabilitation period combined with good cosmetic and clinical results favor the use of the arthroscopic technology in the surgical treatment of tuberculous arthritis of the knee.

Adolescent↗
PubMed2004

Use of polymerase chain reaction to diagnose tuberculous arthritis from joint tissues and synovial fluid.

CONTEXT: Tuberculosis of the joints and bones is a significant worldwide problem, often leading to joint and bone destruction. The diagnosis of this disease manifestation is difficult. OBJECTIVE: To assess the role of conventional diagnostics compared to polymerase chain reaction applied to samples obtained at arthroscopy. DESIGN: This was an open observational study that was blinded to the microbiologist, histopathologist, and molecular biologist responsible for assessing the main outcome measures. PATIENTS: Seven patients (8 samples) with joint and bone tuberculosis and 14 patients (16 samples) with nontuberculous joint and bone disease. INTERVENTION: Arthroscopic examination and tissue sample collection. MAIN OUTCOME MEASURES: Mycobacterium tuberculosis staining, culture, and histopathologic assessment of caseating granulomas vs polymerase chain reaction. RESULTS: Polymerase chain reaction was positive in all cases of true tuberculosis and falsely identified 2 samples as positive, both however, in patients who had lung tuberculosis in the past. CONCLUSIONS: Conventional bacteriological methods for demonstration of M tuberculosis are not very sensitive and can be time-consuming. Polymerase chain reaction of arthroscopically obtained joint tissue biopsies appears promising in the early diagnosis of tuberculous arthritis.

Arthritis, Infectious↗