Biomedical subjects

Alfredo Celis

Publications and source records attributed to Alfredo Celis.

7 recordsLinked to original sources

PubMed2006

Factors associated with permanent work disability in Mexican patients with rheumatoid arthritis. A case-control study.

OBJECTIVE: To assess factors associated with permanent work disability (PWD) in Mexican subjects with rheumatoid arthritis (RA). METHODS: From a database of 300 salaried workers with RA, we evaluated 35 cases that developed PWD. These cases were compared with 70 controls randomly selected from the same database who were active workers. The assessment included the following variables: sociodemographic, education, employment, and clinical characteristics of the disease. Logistic regression analysis was performed to adjust variables associated with PWD. Odds ratios and their 95% confidence intervals (95% CI) were computed. RESULTS: Factors associated with PWD in the unadjusted analysis were: lower education level (OR 3.27, 95% CI 1.28-8.49, p = 0.006), >or= 2 year delay in prescription of a disease modifying antirheumatic drug (DMARD) (OR 4.29, 95% CI 1.49-12.73, p = 0.02), joint prosthesis (OR 8.93, 95% CI 2.02-45.04, p < 0.001), severe radiographic damage (OR 3.33, 95% CI 1.20-9.46, p = 0.01), comorbidity (OR 7.54, 95% CI 1.94-34.25, p < 0.001), and positive rheumatoid factor (RF) (OR 3.53, 95% CI 0.98-13.76, p = 0.03). In the multivariate model PWD was predicted by lower education (OR 3.3, 95% CI 1.1-9.7, p = 0.03), positive RF (OR 4.9, 95% CI 1.2-19.7, p = 0.03), and delay in the prescription of a DMARD (OR 3.3, 95% CI 1.1-10.1, p = 0.04). CONCLUSION: A low education level, positive RF, and delay in the use of DMARD are risk factors for PWD. Strategies to decrease rates of PWD should include an earlier treatment with DMARD.

Antirheumatic Agents↗

PubMed2006

Risk factors and incidence of posttransplant diabetes mellitus in Mexican kidney recipients.

BACKGROUND: Many risk factors are associated with the development of posttransplant diabetes mellitus (PTDM), which has adverse effects on graft and patient survival. We report the incidence and risk factors associated with the development of PTDM in Mexican kidney recipients. METHODS: In a retrospective cohort study, we included kidney transplants performed between January 1, 1994 and December 31, 2000; all patients were followed up for at least 1 year posttransplantation. PTDM was defined as fasting blood glucose >126 mg/dL on at least two occasions. Statistical analysis included estimation of crude relative risk (RR) with 95% confidence intervals (CI). Adjusted RR and 95% CI by logistic regression were used. RESULTS: We studied 522 kidney recipients. Fifty three (10.1%) cases of PTDM were identified in this cohort. Cumulative dosage of prednisone (PDN) >13 g (RR 7.6, 95% CI 1.5-16.3 p <0.0001) and the presence of >or=1 acute rejection episodes (RR 3.7, 95% CI 1.2-11.6 p <0.001 were independent risk factors associated with the development of PTDM. Obesity (RR 2.6, 95% CI 0.8-8.7, p = 0.083) and age range of 40-49 years (RR 2.0; 95% CI 0.6-7.2, p = 0.093) were identified as marginal risk factors. CONCLUSIONS: The incidence of PTDM in kidney recipients was 10.1% in our population. Cumulative PDN dosage and presence of >or=1 acute rejection episodes were independent risk factors for the development of PTDM. These results are consistent with prior studies of the diabetogenic effect of the PDN. The relationship between acute rejection and PTDM deserves further investigation in order to learn more about the role that inflammatory mechanisms may play in this association.

Adult↗

PubMed2005

Occupational lifting tasks as a risk factor in low back pain: a case-control study in a Mexican population.

The objective of this study was to quantify and assess whether lifting tasks in the workplace are a risk factor in lumbar spondyloarthrosis etiology. A case-control study was performed with 231 workers, 18-55 years old, insured by the Mexican Social Security Institute (IMSS, according to its designation in Spanish). A multivariate analysis using conditional logistical regression showed that lifting tasks, combined with driving tasks, are associated with this illness (OR = 7.3; 95% CI 1.7-31.4). The daily frequency of lifting as it interacts with work as a driver resulted in a greater risk (OR = 10.4; 95% CI 2.0-52.5). The load weight, daily task-hours and cumulative time showed a dose-response relationship. The attributable risk for lifting tasks was 0.83, suggesting that 83% of lumbar spondyloarthrosis development could be prevented if risk factors were eliminated by ergonomic redesign of the task.

Adolescent↗

PubMed2003

[Trends of adolescent injury and poisoning mortality].

OBJECTIVE: To describe the external causes of death and mortality trends due to injuries and poisoning in Mexican adolescents, from 1979 to 1997. MATERIAL AND METHODS: This is a descriptive study of deaths occurring in Mexico from 1979 to 1997. Data were abstracted, coded, and entered in electronic format, by Instituto Nacional de Estadística, Geografía e Informática (National Institute of Statistics, Geography, and Informatics, INEGI). Data were analyzed during the second half of year 2000, in Jalisco, at the Research Unit of Epidemiologic and Adolescent Health Services, of Instituto Mexicano del Seguro Social (Mexican Institute of Social Security, IMSS). RESULTS: Injuries and poisoning ranked first as causes of adolescent mortality in Mexico (rate = 13.35/100,000), decreasing 41.4% from 1979 to 1997. However, an increasing trend was observed for homicides and suicides (9.5% y 104.0%, respectively). The most frequent mechanisms of injury were: motor vehicles, firearms, intoxications, suffocation, and drowning. CONCLUSIONS: Injuries and poisoning in developing countries show differences from those reported in developed countries. Further studies should be conducted to find preventive measures consistent with the sociocultural and environmental determinants of injuries and poisoning.

Adolescent↗

PubMedDate not supplied

Thrombophilic polymorphisms in preterm delivery.

Single nucleotide polymorphisms tumor necrosis factor (TNF) G-308A, coagulation factors V G1691A and II G20210A, methylenetetrahydrofolate reductase (MTHFR) C677T, as well as the angiotensin-converting enzyme (ACE) insertion/deletion polymorphism were investigated in 86 women with a history of premature delivery (PD) and compared with those of a control group of adults from Guadalajara, Mexico (a minimum of 162 individuals were typed for each polymorphism). Significant differences in the frequency of these polymorphisms were found for MTHFR C677T (increased), and the ACE deletion (increased) among women who had a history of preterm delivery compared with controls. These polymorphisms therefore might be associated with PD.

Adolescent↗

PubMedDate not supplied

[Asphyxiation by suffocation and strangulation in children younger than 15 years of age].

OBJECTIVE: Our aim was to describe non-intentional strangulation or suffocation suffered by children under 15 years of age. METHODS: Records from the Medical Examiner's Office showed child death by non-intentional strangulation or suffocation from January 1, 1991 to December 31, 2001. RESULTS: A total of 44 suffocations or non-intentional strangulations were registered. Overall mortality was 3.62/1,000,000 persons-year (27.57/1,000,000 in children < 1 year of age, 1.94/1,000,000 in older children); 63.6% were males. Most frequent mechanisms included neck entrapment between bars 18.2%, facial obstruction by bed clothes 15.9%, being covered by rubble, sand, or garbage 15.9%, strangulation by cord, chain, or strip 11.4%, and strangulation by dress or bed clothes 9.1%. CONCLUSIONS: Nearly all registered deaths could be prevented by education, supervision, or structural modifications. Strategies should also include obligatory standards for manufacturing and for warnings on labels.

Accidents↗

PubMedDate not supplied

[Mortality from contact with poisonous snakes and lizards in Mexico from 1979 to 2003].

OBJECTIVE: To describe the trend of standardized mortality by contact with poisonous snakes and lizards in Mexico from 1979 to 2003. MATERIAL AND METHODS: We describe the standardized mortality trend by contact with poisonous snakes and lizards occurring in Mexico from 1979 to 2003, and report the mortality data bases from the INEGI (Instituto Nacional de Estadística, Geografía e Informática). We determined frequencies, percentages, mortality rates, standardized mortality rates and mortality relative risks with 95% confidence intervals. RESULTS: The general trend shows a statistically significant descent of 63.8%. The highest mortality rate within the 2000-2003 period was reported in Quintana Roo (7.47/1,000,000), Oaxaca (4.01/1,000,000), Veracruz (1.56/1,000,000), Chiapas (1.48/1,000,000), Campeche (1.43/1,000,000) and Yucatan (1.29/1,000,000). The groups with the highest risk are those older than 60 years and males. CONCLUSIONS: In spite of the detected decrease in mortality, the contact with poisonous snakes and lizards still is a public health problem in Mexico. As timely treatment saves lives, it is necessary to include and offer treatment in all emergency units of the country.

Adolescent↗