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Biomedical subjects

Ali Keshavarzian

Publications and source records attributed to Ali Keshavarzian.

23 records · Page 2Linked to original sources
PubMed2002

Focal rectal capillaritis: microscopic polyangiitis presenting as painless rectal bleeding.

Microscopic polyangiitis is a pauci-immune, necrotizing, small-vessel vasculitis without evidence of granulomatous inflammation. Gastrointestinal involvement is rare and is predominantly limited to abdominal pain. Until now, the gold standard for diagnosis has been an invasive lung or kidney biopsy. We report the case of a 59-year-old woman with microscopic polyangiitis presenting as painless rectal bleeding, which was diagnosed by rectal mucosal biopsy. This is the first reported case of microscopic polyangiitis with initial presentation of rectal bleeding and diagnosis made by rectal mucosal biopsy.

Biopsy↗
PubMed2002

Differential effects of T-cell activation on gastric and small bowel permeability in alcohol-consuming mice.

BACKGROUND: A number of variables influence the effect(s) of alcohol on distinct segments of the intestine. In these studies, we examined the effect of T-cell activation on gastric and small bowel permeability in alcohol-fed mice. METHODS: Gastric permeability was assessed using sucrose absorption, whereas small bowel permeability was followed using the ratio of lactulose to mannitol absorption and inulin absorption. T cells were activated by injecting antigen OVA(323-339) into DO11.10 T-cell receptor transgenic mice. RESULTS: T-cell activation increased gastric and small bowel permeability through a pathway mediated by interferon-gamma and tumor necrosis factor. In mice that were fed a liquid diet that contained 30% ethanol-derived calories for 2 weeks, T-cell activation increased gastric permeability to levels greater than that observed in solid diet or pair-fed, liquid control diet. By comparison, changes in small bowel permeability induced by T-cell activation were abrogated in alcohol-fed mice. Analysis of intestinal cytokine mRNA levels (interferon-gamma and tumor necrosis factor) indicated that relevant mucosal T-cell function was preserved in alcohol-fed mice. CONCLUSIONS: Overall, these data suggest that alcohol potentiates the effects of T-cell activation on gastric permeability, at the same time blunting effects on small bowel permeability

Alcohol Drinking↗
PubMed2002

New developments in the treatment of inflammatory bowel disease.

Therapy of inflammatory bowel disease (IBD) is rapidly changing with the advent of new discoveries in disease pathogenesis. The need for targeted therapies against the uncontrolled immuno-inflammatory reaction in IBD together with a prerequisite for minimal side effects is driving improvement in old medicines and is leading to the development of new drugs. This review introduces emerging changes in IBD treatment, such as improvements in conventional IBD medications or their use. Balsalazide, budesonide and changes in the use of 5-aminosalicylate (5-ASA) products and purine analogues, such as azathioprine, are discussed. Additionally, studies examining the role of drugs newly introduced into IBD therapy, such as mycophenolate mofetil (MMF), thalidomide and heparin, are stated. Emerging biological therapies, such as therapies against TNF, therapies to enhance anti-inflammatory cytokines, therapeutic manoeuvres to disrupt immune cell trafficking, anti-oxidant therapies, as well as non-conventional treatments, such as diet therapies, prebiotics and probiotics, and helminth therapies are discussed.

Anti-Bacterial Agents↗
PubMedDate not supplied

Laparoscopic wedge resection of gastric leiomyoma.

Gastric leiomyoma is a relatively rare gastric neoplasm. Before the routine use of laparoscopy, various methods of treatment for gastric leiomyoma included open celiotomy with gastric wedge resection, partial gastrectomy, enucleation, and extended gastrectomy with en bloc resection of adjacent organs. Below, we describe a case of laparoscopic wedge resection and review the various laparoscopic techniques for the treatment of gastric leiomyoma.

Female↗