Biomedical subjects

Ali Yener

Publications and source records attributed to Ali Yener.

6 recordsLinked to original sources

PubMed2006

Autoimmune myasthenia gravis after coronary artery bypass surgery.

Myasthenia gravis is the most common disorder of neuromuscular transmission and is a heterogeneous disorder that is generally autoimmune, which is caused by an auto-antibody to the nicotinic acetylcholine receptor. We present a rare case of myasthenia gravis that occurred 8 weeks after a coronary artery bypass grafting operation. A 64-year-old man with multivessel coronary artery disease underwent myocardial revascularization. Severe myasthenic symptoms began 8 weeks after the operation and emergent mechanical ventilation was needed because of myasthenic crises. The serum anti-acetylcholine receptor antibody level was high. The details of this unusual patient are discussed.

Antibody Formation↗

PubMed2005

Double right coronary artery; fistula and atherosclerosis: rare combination.

Combination of the primary congenital coronary artery anomalies, fistula and atherosclerosis rarely occur. We report a 50-year-old male who presented with severe chest pain, for which he underwent a coronary angiography. Injection into the right coronary artery (RCA) demonstrated a double RCA running very closely together in the atrioventricular groove. The superior one gave rise to a coronary fistula leading to the right ventricle and the inferior one was atherosclerotic. Both of them terminated as a posterior descending artery. The left system showed occlusion of the left anterior descending and major obtuse marginal. Both were corrected surgically.

Comorbidity↗

PubMed2004

Quadricuspid aortic valve: a chance for repair.

Quadricuspid aortic valve is an uncommon congenital anomaly that often causes aortic regurgitation in adulthood, necessitating valve replacement. A 54-year-old woman presented with symptoms and signs of aortic regurgitation, but during surgery a quadricuspid aortic valve was identified. The abnormal cusp was fibrotic, short, thick, and fenestrated. Excision of the fourth cusp was performed and valve repair carried out successfully, with only minimal regurgitation.

Aortic Valve↗

PubMed2002

Serous fluid leakage without seroma after aortobifemora bypass operation.

Perigraft seroma and serous fluid leakage is an uncommon clinicopathologic entity. Serous leaks and/or seroma formation from dacron grafts have been reported in peripheral arterial anastomoses. We present a case of serous fluid leakage without seroma which developed after aorto-bifemoral and femoro-popliteal bypass.

Aorta↗

PubMed2002

Bicuspid aortic valve.

The bicuspid aortic valve is a common congenital cardiac anomaly, having an incidence in the general population of 0.9% to 2.0% and a frequency of 54% in all patients aged >15 years with valvular aortic stenosis. In most cases it remains undetected until infective endocarditis or calcification supervenes. The bicuspid aortic valve may function normally throughout life, may develop progressive calcification and stenosis or may develop regurgitation with or without infection. The association of the bicuspid aortic valve with dissection of the aorta is also common. The recognition of the bicuspid valve in patients with aortic valve disease remains an important challenge to the clinician, whereas preoperative knowledge of valve morphology would be helpful in planning the surgery. Antibiotic prophylaxis is also recommended in such patients, since these valves are likely to become the most important intrinsic cardiac predisposition for infective endocarditis with the virtual disappearance of rheumatic fever in developed countries.

Aortic Valve↗

PubMedDate not supplied

Magnesium decreases cardiac injury in patients undergoing coronary artery bypass surgery.

BACKGROUND: The calcium-channel blocking effect of magnesium might have protective effects in patients undergoing cardiopulmonary bypass surgery. We assessed the effects of magnesium on hearts undergoing coronary artery bypass surgery with intermittent warm blood hyperkalemic cardioplegia in the antegrade fashion. PATIENTS AND METHODS: Twenty patients undergoing coronary bypass surgery were randomly divided into two groups, a control group who received intermittent antegrade warm blood hyperkalemic cardioplegia for myocardial protection, and a study group who received the same solution with the addition of magnesium to the cardioplegia. Extracellular substrates (creatinine phosphokinase, creatinine phosphokinase-MB group, lactate dehydrogenase, c-reactive protein, and cardiac troponin I were measured preoperatively and postoperatively. RESULTS: There were significant differences in the post-operative concentrations of creatinine phosphokinase, creatinine phosphokinase-MB group, c-reactive protein, and lactate dehydrogenase after cardiopulmonary bypass (P<0.001) in the study group compared with the control subjects. Cardiac troponin I levels were also significantly lower in the study group after cardiopulmonary bypass (P<0.005). CONCLUSIONS: Our study indicates that if magnesium is added to intermittent antegrade warm blood hyperkalemic cardioplegia, blood levels of many markers of cardiac myocardial injury after cardiopulmonary bypass are lowered. This finding may have implications for myocardial protection.

Adult↗