Biomedical subjects

Alina Neacşu

Publications and source records attributed to Alina Neacşu.

8 recordsLinked to original sources

PubMed2004

[Phacoemulsification and pseudoexfoliative syndrome].

PURPOSE: To compare the results and the complications of cataract surgery by phacoemulsification in eyes with pseudoexfoliation syndrome (PEX) and without pseudoexfoliation syndrome. METHODS: A retrospective clinical study (January 2001 - January 2004; mean follow-up 21.5 months) of 116 cases divided in two groups: group A (55 eyes) with senile cataract and pseudoexfoliation syndrome and group B (61 eyes) with senile cataract but without pseudoexfoliation syndrome. The eyes were without another associated ophthalmological diseases and the phacoemulsifications were performed by the same surgeon. Intraoperative observations included anterior chamber depth, pupil size after maximal mydriasis, zonular dehiscence, capsule tear, vitreous loss and postoperatively: best corrected visual acuity, intraocular pressure (IOP), aqueous flare response and IOL stability were evaluated at 1 day, 1 week, 1 month and until 3 years. The Student-t test was used for statistical analyses. RESULTS: There were determined significant correlations between pupil size, anterior chamber depth and the rate of complications in the group A. The visual acuities were similar in both groups. IOP reduction was superior in the eyes with PEX as compared with control group, but without statistically significantly difference. In group A, there were a non-statistically significantly percentage of IOL dislocation as compared with group B. In the eyes with PEX, it is necessary to utilize IOLs with bigger optic size. CONCLUSIONS: Phacoemulsification represents a safe method in cataract surgery in eyes with pseudoexfoliation syndrome in the presence of careful surgical technique: maximal mydriasis, circular continuous curvilinear capsulorhexis, adequate hydrodissection. On the long run, the postoperative results were comparable between eyes with PEX and the control group (without PEX).

Cataract↗

PubMed2004

[Biomechanical stress in glaucoma--cause and effect].

UNLABELLED: Glaucoma is a neurodegenerative disease with multifactor causes which is characterized by acute loss of ganglion cells. Many mechanisms are involved in this disease but they are incomplete elucidated. Biomechanical stress generate changes to lamina cribrosa which determine ganglion cells death. STUDY OBJECTIVES: The quantification of changes of LC and peripapillary sclera in experimental models with glaucoma. METHODS AND MATERIAL: A prospective, experimental study (10 weeks) using 8 adult guinea pigs in which glaucoma was induced by equatorial burns (diathermia) at two episcleral veins--right eye, left eye being considered witness. The monitored parameters are: IOP, retro-ocular blood flow, histopathologic examination. RESULTS AND CONCLUSIONS: Constant exposure to biomechanical stress (increase to IOP) involve to local level cellular and molecular mechanisms which made changes in the extracellular matrix. The changes of LC are a mechanism that determine glaucomatous optic nerve disease and became a new option to diagnose and follow in glaucoma.

Animals↗

PubMed2003

[Visual fields defects in cerebral hemorrhagic vascular accident].

Interpretation of the fields of vision forms a key part of ophthalmic and neurologic examinations. The homonymous hemianopa is a hallmark of a retrochiasmal lesion. Postchiasmal lesions that interrupt the visual pathway may have multiple causes which the circulatory disturbances is one of the most important. The authors present the case of a woman who has an isolated homonymous hemianopa produced by a vascular accident of occipital lobe, dwell upon the only manifestation of the cerebral acute hemorrhagic vascular accident was represented by an visual field defect.

Aged↗

PubMed2003

[ Pediatric glaucoma--case report].

Pediatric glaucoma is an interdisciplinary problem because of it's many systemic abnormalities which may encounter with this disease. In this paper we present the follow up and the treatment of a clinical case. We point once again that the therapy used is a most important attitude for the future prognosis.

Abnormalities, Multiple↗

PubMed2003

[Surgical decision in both cataract and glaucoma].

The authors try to establishes the algorithm for the treatment in patients who have both cataract and glaucoma. Clinicians must decide when to do cataract surgery, when to do glaucoma surgery and when to do a combined procedure, as well as decide which technique is appropriate. The paper presents a comparative analyze on three groups of patients who have this pathological association, regarding the factors involved in the surgery decision process and the postoperative results (visual acuity--VA, intraocular pressure--IOP, complications).

Aged↗

PubMed2003

[Conjunctival changes related to topical treatment and effectiveness of surgery in glaucoma].

PURPOSE: The topical treatment for a long run in glaucoma rises histopathological changes of conjunctiva. The study is aimed at assessing the correlations between conjunctival changes bound of the type and duration of medical glaucoma therapy and the efficiency of subsequent filtering surgery. METHOD: For this purpose, we carried out a three years clinical prospective study (01.05.2000-30.04.2003), with a mean follow-up period of 18.5 months, enrolling 22 cases (38 eyes) operated by trabeculectomy for primary open angle glaucoma (POAG), with the same technique and the same surgeon. There were excluded both the patients with previous ophthalmic surgical interventions and ocular/systemic chronic inflammatory disease. The cases were divided according to type and duration of topical treatment. There were recorded the conjunctival changes (by histological exam and immunohistochemistry), dynamic evolution of intraocular pressure (IOP) and the morphological aspects of filtering blebs. Statistical analysis was performed by Wilcoxon test. RESULTS: In all groups, the efficiency of filtering surgery was correlated with the duration of topical medication; the survey presents the correlations between topical treatment, conjunctival changes and postoperative evolution. CONCLUSIONS: These results suggest that exhaustive topical treatment in POAG, for a long period, with many drugs may represent a negative prognostic factor for the subsequent filtering surgery. Therefore it is necessary an individual approach for the first line therapy in POAG.

Administration, Topical↗

PubMed2003

[Neuroprotection with carotenoids in glaucoma].

PURPOSE: The aim of the paper was to assess the place of the natural carotenoids (lutein, zeaxanthin) in glaucoma optic neuropathy. METHODS: For this purpose, we carried out an experimental and prospective study, during 3 months, on 8 laboratory animals (Guinea pigs), which we increased the IOP, in both eyes, by cautery of two episcleral vessels. The animals were divided into treatment in two groups: the group I (5 Guinea pigs) which we modified their usual diets by adding 2 cps/day of IcapsL (6 mg lutein/zeaxanthin) and the group II (3 Guinea pigs)--control group, without increasing the diet with lutein and zeaxanthin. The statistical analysis was performed by Student's t test. RESULTS: Before the cautery of episcleral vessels, the mean IOP was 16.8 mm Hg in group I and 16.5 mm Hg in the group II; after the cautery of episcleral vessels, the mean IOP was 26.2 mm Hg in group I and 25.9 mm Hg in the group II (p = 0.004). At the end of the study, the levels of serum lutein were 0.64 mumol/L in group I and 0.22 mumol/L in group II. The loss of retinal ganglion cells was 18.9% in group I and 29.7% in martor group, in correlation with the cup/disc ratio: 0.37, respectively 0.51. Also, in the group II, the increase of IOP was associated at the myelin portion of optic nerve head with axonal degeneration in peripheral regions. CONCLUSIONS: Glaucoma optic neuropathy has a multifactorial pathogenesis, including the oxidative stress. Lutein and zeaxanthin, with its strong antioxidative effects, can represent a viable solution in the complex treatment of glaucoma.

Animals↗

PubMed2002

[Secondary cataract; correlations concerning lens surgery and pseudophakia type. Therapeutic aspects].

The study presents the correlations concerning the advent of the secondary cataract depending on the surgical technique and pseudofak type (PMMA, acrylic, siliconic), as well the safety and efficacy of the YAG: Nd capsulotomy. A 3 years clinical retrospective trial was done on 320 eyes operated for senile cataract. The incidence of the secondary cataract was 11.4%, usually after 12 months, (the lower in phacoemulsification using acrylic IOL). Nd: YAG capsulotomy being done in cases with visual acuity lower than 0.6.

Acrylates↗