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Biomedical subjects

Alison M Stephen

Publications and source records attributed to Alison M Stephen.

8 recordsLinked to original sources
PubMed2007

Dietary patterns throughout adult life are associated with body mass index, waist circumference, blood pressure, and red cell folate.

Dietary patterns are important in the prevention of chronic disease; however, there are few studies that include repeat measures of dietary patterns. The objective of this study was to assess the relations between dietary patterns during adult life (at ages 36, 43, and 53 y) and risk factors for chronic disease at age 53 y. Participants of a longitudinal study of health completed a 5-d food diary at 3 occasions during adult life (n = 1265). Factor analysis was used to identify dietary patterns and a pattern score was calculated from the consumption of the food items in each dietary pattern. Means and 95% CI for dietary pattern scores were calculated for each risk factor category using random effects models adjusted for socio-demographic and health-related behaviors. In women, the fruit, vegetables, and dairy pattern was inversely associated with BMI (P < 0.004), waist circumference (P = 0.0007), blood pressure (P = 0.02), and was positively associated with red cell folate (P < 0.03). The ethnic foods and alcohol pattern was also inversely associated with blood pressure (P = 0.008), whereas the meat, potatoes and sweet foods pattern was positively associated with glycated hemoglobin (P = 0.01). In men, a mixed pattern was inversely associated with waist circumference (P = 0.02) and blood pressure (P = 0.01), whereas there were no significant associations with the ethnic foods and alcohol pattern. Specific dietary patterns throughout adult life were associated with chronic disease risk factors.

Adult↗
PubMed2003

Soy isoflavones: a safety review.

Soy isoflavones have been a component of the diet of certain populations for centuries. The consumption of soy generally has been considered beneficial, with a potentially protective effect against a number of chronic diseases; because of their estrogenic activity, however, negative effects of isoflavones have been postulated. This review examines the literature associated with the safety of soy isoflavones, including dietary soy isoflavone exposure data of populations with high soy intakes, human studies in which soy protein or isoflavones were provided, and toxicologic studies investigating the potential genotoxicity, carcinogenicity, and reproductive and developmental toxicity of soy isoflavones. Whereas results in some studies are limited or conflicting, when viewed in its entirety, the current literature supports the safety of isoflavones as typically consumed in diets based on soy or containing soy products.

Animals↗
PubMed2003

Diet, obesity and education in three age groups of Saskatchewan women.

Research on relationships between socioeconomic status and Canadians' diet is limited. The current study investigated differences by education in dietary variables shown to be related to obesity; it included three age groups of Saskatchewan women who participated in the 1992 to 1993 Heart Health Intervention Evaluation baseline study. Multistage sampling was used to select randomly from the Saskatchewan Health Insurance Registration File. The overall response rate was 42.6%; a sample representative of the general Saskatchewan population was obtained. Three-day estimated food records and demographic information from 396 women aged 18 to 74 years were subdivided into three age categories: 18 to 34 years, 35 to 54 years, and 55 to 74 years. For the 18- to 34-year group, obesity was significantly more prevalent with lower education; trends were similar for the older age groups. Under-reporting of energy intake (indicated by an energy intake:basal metabolic rate ratio of <1.1) was related to obesity but not to education. The greatest differences in diet between educational groups were observed in the 18- to 34-year group; fewer differences existed in the 35- to 54-year group, and none in the 55- to 74-year group. Health promotion efforts need to be targeted appropriately, and based on differences in dietary intakes by socioeconomic group. Research should help promote an understanding of the reasons for differences in diet by socioeconomic status.

Adolescent↗
PubMed2002

Moderate folate deficiency influences polyamine synthesis in rats.

Spermidine, spermine and putrescine are polyamines, essential growth factors in mammalian cells. Decarboxylated S-adenosylmethionine (SAM) is an essential precursor in the formation of both spermidine and spermine. SAM is formed from methionine through the addition of adenosine. Because 5-methyltetrahydrofolate donates a methyl group to homocysteine to produce methionine, folate deficiency may decrease polyamine synthesis. Weanling male Sprague-Dawley rats were fed an amino acid-defined diet with 2 mg folic acid/kg diet (control) or no added folic acid (test). Blood, liver, brain, jejunum, ileum and colon samples were collected at the end of 5 wk. Compared with controls, rats fed the test diet had a 72% reduction in plasma folate (123.6 +/- 13.1 vs. 34.6 +/- 2.2 nmol/L, P < 0.001) and a 42% reduction in RBC folate (2834.4 +/- 218.3 vs. 1651.8 +/- 75.9 nmol/L, P < 0.001). Hepatic spermidine and spermine in folate-depleted rats were 58 (P < 0.001) and 67% (P < 0.01) higher, respectively, than in controls. Plasma putrescine was 27% higher (P < 0.05) than in controls. The polyamine concentrations of the jejunum, ileum, colon and brain did not differ. This study suggests that mild folate deficiency influences polyamine synthesis, but contrary to our hypothesis, hepatic spermidine and spermine were increased, as was circulating putrescine. This may have occurred for a number of reasons including increased enzyme activity or overcompensation by the betaine-homocysteine transmethylation pathway in the liver. Further study is necessary to clarify interactions between folate and polyamine metabolism and to determine whether polyamines are involved in the damaging effects of folate deficiency.

Animals↗
PubMed2002

Food information programs: a review of the literature.

This paper summarizes existing evidence on the impact of food information programs. Published and unpublished literature produced within the past decade was searched and reviewed. Relevant data were tabulated and key findings summarized. Food information programs are becoming increasingly popular as tools to help consumers select a healthy diet. The key feature of a food information program is a package logo on foods meeting nutrition criteria set by the program s administering body. The logo acts as a health message. Several countries, including Canada, have adopted food information programs. Critics believe that these programs oversimplify the concept of healthy eating, that consumers misinterpret the logo s meaning, that licensing fees prohibit small companies from participating, and that the programs are limited to purchase behaviour and do not necessarily have an impact on dietary intake. Consumers report support for the programs and are able to interpret a logo s meaning accurately. In addition, evidence shows the programs have had a positive impact on the nutrient composition of foods. Research is still needed, however, to establish the impact of such programs on food purchases and dietary intake, and the overall and long-term effectiveness of the programs as a nutrition intervention.

Canada↗
PubMedDate not supplied

Regulation of foods with health claims: a proposal.

Health claims linking foods and food components to disease are prohibited in Canada because of limitations of the Food and Drugs Act. Changes to the Act to permit such claims would require a Bill to Parliament, a lengthy and impractical solution. In this paper, an alternative approach is proposed, that is, to regulate "Foods with Health Claims" under a subsection of the Drug Regulations. Generic claims would be regulated in a similar manner to Class IV or minimum risk drugs, whereby monographs would be created for constituents for which claims are proposed. Product-specific claims would be individually evaluated. Each food bearing a claim would carry a Food Identification Number (FIN), provided by Health Canada through application. Details of procedures and conditions for the FIN process are suggested. The FIN plan would provide an expedient, balanced and accountable approach to allow health claims on food products in Canada.

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