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Biomedical subjects

Amir Muzur

Publications and source records attributed to Amir Muzur.

16 recordsLinked to original sources
PubMed2006

"Marina-Trinkkur" and a few more modern-time hydrotherapeutic myths from the Kvarner region of NW Croatia.

PURPOSE: The present paper tries to address the rise and decay of the sea-water "cult" in regional health tourism in NW Croatia, concentrating upon and analysing more thoroughly the example of Marina, chemically processed sea water, an invention of Dr Géza Fodor, the Hungarian physician practicing in that part of Croatia. METHOD: The original documents and archived items related to the topic were examined. Furthermore, we investigated numerous communal bulletins and medical authorities' records of respective time. RESULTS: Our research showed that the sea-water baths, introduced thanks to the influence of balneologists (like J. Glax), and "drinking cures" (advocated by M.-J. Ortel, for instance) were surprisingly popular not only among tourists of the time, but also among the physicians that used them extensively for therapeutical purposes. These baths and "drinking cures" enriched and completed the medical offer of the resorts regardless of their sometimes dubious effectiveness. CONCLUSIONS: This simple distilled sea-water preparation, advertised as a real panacea, demonstrates a paradigm that elucidates the mentality of physicians, merchants, and patients/consumers of the time.

Balneology↗
PubMed2006

Hypnosis and modern frontal-lobe concepts--a sketch for a review and an invitation to one particularly promising field.

The present paper intends to briefly review the most important concepts of the modern neuropsychology of the frontal lobes, and to relate these findings to the phenomenology usually encountered in hypnosis research and practice. The frontal lobes have been studied very intensively during the last several years and some of the results, including the syndromes described in frontal-lobe lesions and psychiatric patients, demonstrate striking similarity with hypnotic phenomena. Based on these similarities, an alternative neuropsychophysiological definition of hypnosis/suggestion is proposed, viewing hypnosis/suggestion as the process of external manipulation with frontal-lobe functions with consequent effects upon the entire brain potential of the subject.

Brain Diseases↗
PubMed2005

Sleep quality deteriorates over a binge--abstinence cycle in chronic smoked cocaine users.

RATIONALE: In cocaine dependent individuals, changes in subjective and objective sleep quality accompany their characteristic binge-abstinence cycle. Preliminary studies suggest that sleep quality may decline with prolonged abstinence. Reported here are results of the most extensive study to date on sleep abnormalities during cocaine binge and confirmed abstinence under controlled conditions. OBJECTIVES: The purpose of the current study was to use an experimental, inpatient model of the cocaine binge and abstinence cycle to examine the course and magnitude of sleep disturbances during cocaine use and abstinence. METHODS: Five inpatient non-treatment seeking cocaine users completed 3 baseline days of drug abstinence followed by 3 days of medically monitored "binge" cocaine use, and then 15 days of drug abstinence. Physiological sleep was recorded with polysomnography and the Nightcap ambulatory monitor, while subjective sleep was assessed by questionnaire. RESULTS: Across 3 days of binge cocaine use and 15 subsequent days of confirmed drug abstinence, mean sleep duration, efficiency and latency changed in the direction of poorer sleep quality. In contrast, subjective reports of sleep quality remained unchanged across the same period. CONCLUSIONS: Physiological sleep quality deteriorated from days when cocaine was used across the first 2 weeks of confirmed drug abstinence. In contrast, subjective reports of sleep quality remained unchanged across the same period. We postulate that this dissociation between objective and subjective sleep quality results from a cocaine-use related disruption of the sleep homeostat. Worsening sleep quality during cocaine abstinence may contribute to the risk of relapse and its treatment may offer novel therapeutic strategies for cocaine dependence.

Adult↗
PubMed2005

Cognitive performance by humans during a smoked cocaine binge-abstinence cycle.

Five cocaine-dependent individuals completed a 22-day inpatient study of sleep and cognition. Following 3 days of drug-free baseline, participants underwent 3 days of twice-daily smoked cocaine base self-administration (6 50-mg doses, 14 minutes apart), followed by 15 days of abstinence. Each morning and afternoon, the CDR repeatable, multiple-version, computerized cognitive battery (whose stability following practice has been documented) was administered. During abstinence, performance deteriorated on vigilance tasks (especially reaction time) as well as on immediate and delayed verbal recognition tasks but not on working memory tasks. Declines were most evident in the afternoon. Data suggest that abstinence can unmask cognitive deficits induced by chronic cocaine use and circadian factors may mediate their severity.

Adult↗
PubMed2004

Cult of St. Blasius, patron saint of throat sufferers and of otolaryngologists, in Croatia.

In the introductory part presented is a short hagiography of St. Blasius, and the legend of miraculous healing of a child in whose throat a bone had stuck, threatening to choke the child. Thanks to that legend, St. Blasius has become the traditional patron of the laryngeal diseases, and, since recently, the patron of the otolaryngologists, too. The second part of the paper is dedicated to the cult of St. Blasius, which is present in Croatia since the 10th century until present. Venerated all over the country, St. Blasius has been "elected" the heavenly protector of 10 parish communities, as well as of the city and the dioceses of Dubrovnik. Beside pilgrimage and prayers, among many traditional forms of folk piety, a ritual called "grlicenje" has been preserved-a curative and preventive blessing of the throat with crossed candles on the Saint's Day. In more recent times, the same day has been remembered among Croatian otolaryngologists and the societies of laryngectomized persons, who chose St. Blasius for their patron, too.

Ceremonial Behavior↗
PubMed2004

Toward an integrative theory of sleep and dreaming.

Non-rapid-eye-movement sleep (NREMS) is triggered by the accumulation of adenosine, as a result of the perceptual overload of the brain cortex. NREMS starts in the most burdened regions of the cortex first and then eventually, after the released adenosine has reached the ventrolateral pre-optic nucleus area of the hypothalamus, triggers the "general NREMS pattern". This is accompanied by the usual familiar changes in the thalamocortical system. When NREMS reaches the slow-wave sleep (SWS) phase, with its predominant delta activity, brain metabolism drops significantly with the brain temperature, and this is recognized by the alarm system in the pre-optic anterior hypothalamus and/or the other thermostat circuit in the brainstem as a life-threatening situation. This alarm system triggers a reaction similar to abortive or partial awakening called rapid-eye-movement sleep (REMS), which is aimed at restoring the optimal body-core temperature. As soon as this restoration is accomplished by the activation of the brainstem-to-cortex ascending pathways, NREMS may continue, as may the interchange of the two sleep phases during the entire sleep period. During both NREMS and REMS, the same essential pattern occurs in the cortex: the loops "used" during the previous waking period, now deprived of external input, replay their waking activity at a lower frequency, one which enables them to restore the membrane's potential (possibly by means of LTD). During REMS, however, the cholinergic flood originating in the LTD/PPT nuclei of the pons tegmentum, increases in the basal forebrain and, provoking theta activity in the medial septum is extended to the hippocampus, causing the circuits that are active at that particular moment in the cortex, to store the information they carry as memory. This is the explanation of both the memory improvement known to be related to REMS and of dreams. Both phenomena are clearly side effects of REMS.

Animals↗
PubMed2004

The cult of St. Lucia, patroness of the eyes: some examples from Croatian ethnomedical tradition. On the occasion of the 1700th anniversary of her martyrdom.

In the introductory part, the authors present several patrons/patronesses of the eyes and sight, as well as the protectors from eye diseases. In addition, presented is a short hagiography of St. Lucia, the most famous among the patrons of the eyes. The second part is dedicated to the cult of St. Lucia, which has existed among the Croats from the 10th century until present day. Testimonies to this are numerous churches, chapels, altars, paintings, sculptures, processions, pilgrimage, prayers, votive gifts, and many other forms of folk piety. By reviewing several characteristic examples from Istria and the region of Kvarner, the importance of this veneration is indicated, for general and religious tradition as well as for the history of medicine, especially the history of ethno-ophthalmology.

Croatia↗
PubMed2004

Skrljevo disease: between myth and reality.

At the end of the 18th century, an epidemic of allegedly unknown disease characterized by inconsistent symptoms broke up in Istria, Croatia. The disease was called Skrljevo disease after the village Skrljevo, near Rijeka, where it first emerged. We critically evaluated archive material, books, and papers on this disease published during the last 200 years. According to these records, the "illness" spread quite rapidly, affecting around 13000 people at its peak around the mid-19th century. Dozens of papers, books, and dissertations were written, trying to elucidate the nature and cause of the "epidemic." By the end of the 19th century, the "disease" had mostly disappeared, but the questions it had raised did not. We believe that this "disease" was not a real epidemic, but actually the rise (and fall) of a "fashionable diagnosis". We recognized certain similarities in ethical and popular aspects between the story of the Skrljevo disease and acquired immunodeficiency syndrome.

Croatia↗
PubMed2004

Make love to forget: two cases of transient global amnesia triggered by sexual intercourse.

Transient global amnesia (TGA) is characterized by a sudden onset and by a typical resolution within several hours. Several precipitating events have been proposed: physical exertion, emotional experiences, etc. The aim of this paper was to present two cases of TGA triggered by sexual intercourse and to suggest a possible mechanism for the development of TGA. In both patients, clinical examination revealed elevated blood pressure. Laboratory examinations and brain CTs were normal. EEG demonstrated diffuse dysrhythmia and slow spike-waves, respectively. SPECT revealed hypoperfusion in the left frontal and right medial temporal regions. Various explanations of the mechanism of TGA are discussed. Based on the observed hypoperfusion in the medial temporal regions, a new hypothesis is advanced, suggesting the possibility that TGA occurs due to a pathologically changed or less adaptable anterior chorioid artery, initially constricted by hypotension following a blood shift from the center towards periphery.

Amnesia, Transient Global↗
PubMed2003

Visuomotor deficits and fast recovery after area V6A lesion in monkeys.

In order to study the involvement of area V6A in visually guided behavior, restricted lesions to the anterior bank of the parieto-occipital sulcus (POs) were made in two adult Cercopithecus aethiops monkeys, trained in visuomotor tests. Beside the known clinical signs of parietal deficit (abnormal posture of the arm contralateral to the most recent lesion and reluctance to use it), misreaching was evident soon after surgery and disappeared quickly. Uncertainties in a landmark test and prolonged response times to the pressing of light-buttons lasted for a few weeks and 1 month, respectively. As suggested by previous anatomical and physiological data, these findings confirm the role of the POs region in the execution of reaching movements. Moreover, they also demonstrate that following lesion, locally networked areas can rapidly adjust in order to re-establish pre-lesional behavior. These adjustments take place well before that any anatomical changes may occur.

Animals↗
PubMed2003

Two examples of reimplantation from Croatian sacral patrimony.

In the current article, two paintings related to the topic of reimplantation from Croatian sacral patrimony are presented. The first one is "The Kiss of Judas," the fresco by Vincent of Kastav (1474) in Beram in Istria--a Gospel scene with Jesus performing reimplantation of the ear to Malchus after it was cut off by Apostle Peter. The second one is an old oil on canvas from the island of Rab, presenting St. Anthony of Padua performing reimplantation of a boy's amputated foot. Although in both cases the primary function of the painting is to convey a moral message, they are interesting from the medical-historical point of view for their view of universal popular imagination and the conception of healing severe wounds during the absence of modern medical knowledge.

Christianity↗
PubMed2003

Hungarian doctors and the "Golden Age" (1884-1914) of Opatija (Croatia).

At the turn of the 20th century, in the frame of the Austro-Hungarian Monarchy, Hungarian enterpreneurs - backed by the Hungarian government - attempted to launch a "Hungarian area" on the Adriatic coasts with the center of Crikvenica and Abbazia (presently Opatija). (This time Fiume (Rijeka), as the only Hungarian seaport has been partly possessed and governed by Hungarians). Author gives a short overview on these attempts with a special regard to the activity of Hungarian physicians on the Adriatic coasts, especially in Abbazia (Opatija) and to the health resorts founded by them, respectively. He calls our attention to the fact, that as a result of the activity of Hungarian physicians and enterpreneurs this period proved to be the so called "golden age" of Abbazia and of its environment.

Balneology↗
PubMed2002

The prefrontal cortex in sleep.

Experimental data indicate a role for the prefrontal cortex in mediating normal sleep physiology, dreaming and sleep-deprivation phenomena. During nonrandom-eye-movement (NREM) sleep, frontal cortical activity is characterized by the highest voltage and the slowest brain waves compared to other cortical regions. The differences between the self-awareness experienced in waking and its diminution in dreaming can be explained by deactivation of the dorsolateral prefrontal cortex during REM sleep. Here, we propose that this deactivation results from a direct inhibition of the dorsolateral prefrontal cortical neurons by acetylcholine, the release of which is enhanced during REM sleep. Sleep deprivation influences frontal executive functions in particular, which further emphasizes the sensitivity of the prefrontal cortex to sleep.

Journal Article↗
PubMed2002

Effects of lesions to area V6A in monkeys.

In order to assess the role played by area V6A in visuomotor control, two adult green monkeys ( Cercopithecus aethiops) were subjected to small, bilateral lesions in the anterior bank of the parieto-occipital sulcus. Before and after the lesions, monkeys were tested for naturally designed reaching, grasping and picking-up pieces of food from various positions on a plate and from a differently oriented narrow slit. All movements were recorded with closed circuit TV and analysed offline on a single-photogram basis for defective reaching and wrist orientation. V6A lesions provoked parietal weakness, reluctance to move, and specific deficits in reaching, wrist orientation and grasping. Recovery from the observed deficits was rapid, even after a second, contralateral lesion was given, creating a bilateral lesion. Thus, together with previous anatomical and electrophysiological data, these results directly support the hypothesis that area V6A is part of the network involved in the control of reaching movements and wrist orientation.

Animals↗
PubMed2002

Saints protectors from leprosy: historical hints of suggestive therapy?

A short overview of several saints, venerated in Christian tradition as protectors from leprosy, is offered as an introduction to a more substantial debate on the possibility and sense of analyzing historical sources and the use of their interpretation for modern medical practice. A possible psychoneuroimmunological mechanism has been advanced to relate some of the healings of leprosy reported in historical materials.

Christianity↗