The inhibition of factor inhibiting hypoxia-inducible factor (FIH) by beta-oxocarboxylic acids.
Cyclic beta-oxocarboxylic acids inhibit factor inhibiting hypoxia-inducible factor via ligation to the active site iron.
Carboxylic Acids↗
Biomedical subjects
Ana Conejo-Garcia
Publications and source records attributed to Ana Conejo-Garcia.
A prodrug system for hydroxylamines based on esterase catalysis.
The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. Gamma-hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.
Catalysis↗