Biomedical subjects

Anca Indrei

Publications and source records attributed to Anca Indrei.

8 recordsLinked to original sources

PubMedDate not supplied

[Effects of polyamine-loaded liposomes on liver mitochondrial permeability transition].

The objective of the present study was represented by the effects of polyamineloaded liposomes on hepatic mitochondrial permeability transition (MPT). MPT was appreciated through the swelling of the isolated guinea-pig liver mithocondria induced by Ca2+, at 540 nm, using a diode-array 8452 UV-VIS spectrophotometer and a General Purpose software (Hewlett-Packard). Polyamines encapsulated in liposomes might inhibit the appearance of MPT induced by Ca2+, directly proportional to electrical charge: spermine > spermidine > putrescine > cadaverine. Thus, together with some previous data, it was observed that spermine may modulate hepatic MPT from the exterior, as well as from the interior of mitochondria. Moreover, spermidine and putrescine may also modulate MPT from the interior of mitochondria at low doses, and from the exterior only at high doses. The changes in mitochondrial membranes lipid composition (as done by control liposomes) are slightly influencing the MPT. The increase in membrane rigidity through the use of 40% cholesterol-enriched liposomes is drastically decreasing the appearance and development of MPT.

Animals↗

PubMedDate not supplied

[Phytoestrogens role in bone functional structure protection in the ovariectomized rat].

Effects of soy protein diet on bone formation and density were evaluated in ovariectomized rats as a model for postmenopausal women. Twenty-seven 9-month-old rats were assigned to 3 treatment groups for the 9-week study: sham-surgery (Sh, n = 9); ovariectomy (Ovx, n = 9); ovariectomy + soy diet (OvxS, n = 9). Rats had free access to an AIN-93 M diet or AIN-93 M diet with 7% soy protein concentration and water. At sacrifice, rear legs were removed, and the right femur and tibia were cleaned manually. Serum alkaline phosphatase, a marker of bone formation, was measured colorimetrically. Bone density was measured using Archimedes' Principle. Alkaline phosphatase activity was greater in OvxS (114 +/- 19 U/L) and Ovx (128 +/- 26 U/L) compared to Sh (110 +/- 22 U/L). Femur bone density was greater for OvxS (1.520 +/- 0.02 g/cc) compared to Ovx (1.510 +/- 0.017 g/cc), but not to Sh (1532 +/- 0.025 g/cc). Tibia bone density was greater for OvxS (1.560 +/- 0.019 g/cc) compared to Ovx (1.553 +/- 0.015 g/cc), but not to Sh (1566 +/- 0.03 g/cc). In conclusion soy protein diet increased the rate of bone formation and bone density in some bones, suggesting that may help prevent bone loss in postmenopausal women.

Alkaline Phosphatase↗

PubMedDate not supplied

[Cajal interstitial cells identification].

Cajal interstitial cells are cells that are found in the abdominal digestive system wall, between neurons and smooth muscular tissue. They are considered to be pacemakers for slow intestinal waves. The paper discuss about the electron-microscopic identification of Cajal interstitial cells in the rat small intestine wall, cell morphology, placement of these cells in the muscular layer and the relation between Cajal interstitial cells and the components of the nervous plexus. Fragments of rat small intestine have been prepared for electron microscopy examination. Cajal interstitial cells have been found in different locations: in the circular muscular layer, around the nervous nodes and between the muscular layers (longitudinal and circular). The main morphologic characteristic of these cells is the aspect of cytoplasm, with numerous vacuoles and long extensions, some of them very thin, with a tendency to divide. Some Cajal interstitial cells form a network that surrounds the nervous nodes. Other form junctions with the muscular cells and with the interstitial neurons.

Animals↗

PubMedDate not supplied

[The cell-cell interaction mechanisms and specific reactions in zona fasciculata cells from the adrenal gland].

It seems that the particular intermediary disposal of zona fasciculata in the cortical ensemble of the adrenal gland is not insignificant, especially for the variability and for the glandular activities. Because of its specific cellular arrangement, displaying both positional and dimensional uniformity; it can be considered like a real islet of orderly cordonal symmetric tissue between two other cortical zones which present instead a very irregular cellular disposal. Distinct capsular fibrillar elements inserted around the cells and especially around small calibre vascular structures from zona fasciculata, are directly involved in the distribution of the secretory products. The concentration of the lipidic components is always more important at this cortical level than anywhere else in the whole adrenal gland, probably in connecting with the microsystem of channels from the entire surface of the zona fasciculata cells.

Cell Communication↗

PubMedDate not supplied

[Gelatinases in peri-implantation stage].

The periimplantation stage in mice is marked around the 5th day after mating by blastocyst presence in the emdometrium. The events that are marking the implantation event are focused on the evolution of the extracellular matrix around the mezenchime cells that undergoes decidualization. The inductive process is guided by gelatinases and the purpose of our study is to demonstrate their presence at this level.

Animals↗

PubMedDate not supplied

[Alcohol intake assessment in a group of hypertensive adults].

The assessment was realised in order to obtain data for a local intervention program for preventing primary hypertension in young adults through an education program. 269 persons, of both sexes, were investigated. The frequency of elevated blood pressure values is 11.2% and the prevalence of arterial hypertension is 8.73%. The frequency of alcohol consumers is different according to gender (18.6% for male and 3.4% for female).

Adult↗

PubMedDate not supplied

[Temporo-mandibular joint. Morpho-functional considerations].

The temporo-mandibular joint is distinguished from most other synovial joints of the body by two features: 1. the two jointed components carry teeth whose position and occlusion introduce a very strong influence on the movements of the temporo-mandibular joint and 2. its articular surfaces are not covered by hyaline cartilage, but by a dense, fibrous tissue. This paper describes the parts of the temporo-mandibular joint: the articular surfaces (the condylar process of the mandible and the glenoid part of the temporal bone), the fibrocartilaginous disc which is interposed between the mandibular and the temporal surface, the fibrous capsule of the temporo-mandibular joint and the ligaments of this joint. All these parts present a very strong adaptation at the important functions of the temporo-mandibular joint.

Humans↗

PubMedDate not supplied

[Anatomic and anthropologic considerations on mandible].

The mandible is one of the most important bones of the face, by its function in the temporomandibular joint and by its role in the facial aesthetics. From this reason, our article makes some measurements on the mandible (the mandibular length, the bicondylar breath and the mandibular index). We made the measurements on 20 masculine and feminine skulls.

Adult↗