Anca Neagu | PubMed Health

PubMedDate not supplied

[Assessment of prognostic factors in breast cancer].

Prognostic factors predict the long term outcome of treatment, recurrence rate and overall survival. Treatment decision is based on assessment of prognostic factors. They are classified as clinical (age, menopausal status, tumoral growth rate, inflammatory signs), histological (tumoral stage, pathological type, grading, tumoral necrosis, lymph nodes status, margins status) and biological factors (steroidal receptors pattern, ploidy etc). There are tumor markers currently evaluated, being considered conventional and new markers that are not usually evaluated. Patients with negative lymph node will show no recurrences after surgery and/or radiotherapy in 70% of the cases. Factors with specific prognostic value are used for deciding on the therapeutic strategy in negative axillary node cases.

Biomarkers, Tumor↗

PubMedDate not supplied

[Breast conservative surgery].

Breast conservative therapy is considered an adequate therapeutical method for early stage breast cancer. Breast conservative treatment consists of partial mastectomy, axillary dissection and radiotherapy. Patient selection is based on clinical, histological and individual factors. The frozen sections examination provides prompt differentiation between benign/malign lesions and precise assessment of the oncologic margins of the specimen. Preoperative marking of nonpalpable breast lesion with hook wire represents a progress for breast conservative treatment. Sentinel lymph node biopsy represents an alternative to axillary dissection, in order to reduce subsequent morbidity.

Breast Neoplasms↗