Biomedical subjects
Publications and source records attributed to André De Cian.
Ferrocene carboxamide, FcCONH(2), forms homo- and heteroleptic complexes with Co(II), Ni(II) and Cu(II) via coordination of its carbonyl group. Whereas for both Co(II) and Ni(II), hexaferrocenyl complexes are obtained in the presence of BF(4)(-) anion, in the case of Cu(II) a tetraferrocenyl species is observed in the presence of triflate anion.
Tetra- and hexa-nuclear mercury(II) complexes have been obtained from tetrathiacalix[4]arene and tetramercaptotetrathiacalix[4]arene, respectively, and structurally characterised in the solid state; the complexes provide new digonal and trigonal receptors of the koiland type.
Using 4,4',4"-tricyanotriphenylmethanol 1 as a heterotetradentate tecton with C3v symmetry bearing three CN and one OH group, under self-assembly conditions a 3-D coordination network was obtained in the presence of Ag+ cations acting as a tetrahedral metallic tecton; due to the metrics of 1 (three long and one short distance between the central C atom and N and O coordination sites, respectively), the 3-D network is of pseudo-diamondoid type with different cavity sizes; although a two-fold homo-interpenetration is observed for the 3-D networks, the remaining space is occupied by CHCl3, MeOH solvent molecules and SbF6- anions.
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The effect of tBuP4, a strong and cation-free base, on the yield and diastereoselectivity of additions of thus formed "naked" alpha-sulfonyl carbanions to achiral butyraldehyde and chiral isopropylideneglyceraldehyde was studied. It has been found that with tBuP4 a reasonable yield ( approximately 55%) and a slightly better diastereoselectivity (72% of the anti diastreomer) are obtained with achiral and nonfunctionalized butyraldehyde while with isopropylideneglyceraldehyde the use of tBuP4 allowed us to greatly increase the yields (up to 95-100%) and the diastereoselectivities (83-89% of a single diastereomer over the four possible diastereomers). It was also shown that the extra oxygen atom in the alpha-position plays a determinant role in this effect.