Andreas Kaal | PubMed Health

PubMed2005

[Diabetic foot ulcers].

Diabetic foot ulcers result from two specific complications: neuropathy and arteriosclerosis. Prompt and appropriate treatment of these often complicated wounds can help reduce complications that may lead to amputation. The most effective way to prevent these complications is to refer patients to interdisciplinary diabetic foot teams. The most important aspects of treatment are off-loading, treatment of infections, establishment of sufficient circulation, and local wound therapy. A specific examination is the basis for risk assessment. Prophylaxis and appropriate management of patients at risk of developing foot ulcers would contribute to reduce the number of amputations among diabetic patients.

Amputation, Surgical↗

PubMed2003

Evaluation of growth hormone stimulation tests in cured acromegalic patients.

UNLABELLED: We have evaluated the GH peak response to insulin tolerance test (ITT) and to GHRH+arginine in 11 patients cured of acromegaly after treatment with surgery/radiotherapy and compared them to a control group matched for age and sex. GH peak response was significantly higher in the control group than in the patient group (11.21+/-6.98 vs. 4.46+/-6.90 ng/ml, p=0.010). Seven patients had a GH peak response of less than 3 ng/ml, compatible with the diagnosis of GH deficiency. Peak GH response after GHRH+arginine was significantly lower in the group of patients with GH peak of less than 3 ng/ml during ITT as compared to the group with GH peak of more than 3 ng/ml, and in all cases the diagnosis of GH deficiency was confirmed. Mean IGF-I level was not different between the patients and controls, as well as between patients with and without GH deficiency diagnosed by the stimulation tests. CONCLUSION: The incidence of GHD diagnosed by stimulation tests is high in patients cured of acromegaly.

Acromegaly↗