Biomedical subjects

Andreas Mayr

Publications and source records attributed to Andreas Mayr.

8 recordsLinked to original sources

PubMed2005

The pressure tunning Raman and IR spectral studies on the multinuclear metal carbyne complexes.

The Raman and infrared (IR) spectra of four tungsten metal carbyne complexes I, II, IV and V [Cl(CO)2(L)W[triple bond]CC6H4[triple bond](C[triple bond]CC6H4)n[triple bond]N[triple bond]C[triple bond]]2M (L = TMEDA, n = 0, M = PdI2 or ReCl(CO)3; L = DPPE, n = 1, M = PdI2 or ReCl(CO)3) were studied at high external pressure. Their pressure-induced phase transitions were observed near 20kbar (complexes I), 15 kbar (complexes II), 25 kbar (complex IV) and 30 kbar (complex V). The pressure-induced phase transition likely is first order in complex I and the pressure-induced phase transitions of complexes II, IV and V are mostly second order. The pressure sensitivities d nu/dp of nu(W[triple bond]C) are high in the low-pressure phase area and very low in the high-pressure phase area due to the pressure strengthening pi back-bonding from metal W to pi* orbital of C[triple bond]O in fragment Cl(CO)2(L)W[triple bond]C. The pressure strengthening metal pi back-bonding from metal Re or Pd to pi* orbital of C[triple bond]O or C[triple bond]N also happened to both of central metal centers of NCPd(I2)CN in complex I and NCReCl(CO)3CN in complex II.

Carbamates↗

PubMed2003

Effectiveness of direct-current cardioversion for treatment of supraventricular tachyarrhythmias, in particular atrial fibrillation, in surgical intensive care patients.

OBJECTIVE: To evaluate primary success rate and effectiveness of direct-current cardioversion in postoperative critically ill patients with new-onset supraventricular tachyarrhythmias. DESIGN: Prospective intervention study. SETTING: Twelve-bed surgical intensive care unit in a university teaching hospital. PATIENTS: Thirty-seven consecutive, adult surgical intensive care unit patients with new-onset supraventricular tachyarrhythmias without previous history of tachyarrhythmias. INTERVENTIONS: Direct-current cardioversion using a monophasic, damped sinus-wave defibrillator. Energy levels used were 50, 100, 200, and 300 J for regular supraventricular tachyarrhythmias (n = 6) and 100, 200, and 360 J for irregular supraventricular tachyarrhythmias (n = 31). MEASUREMENTS AND MAIN RESULTS: None of the patients was hypoxic, hypokalemic, or hypomagnesemic at onset of supraventricular tachyarrhythmia. Direct-current cardioversion restored sinus rhythm in 13 of 37 patients (35% primary responders). Most patients responded to the first or second direct-current cardioversion shock. Only one of 25 patients requiring more than two direct-current cardioversion shocks converted into sinus rhythm. Primary responders were significantly younger and demonstrated significant differences in arterial Po2 values at onset of supraventricular tachyarrhythmias compared with nonresponders. At 24 and 48 hrs, only six (16%) and five (13.5%) patients remained in sinus rhythm, respectively. CONCLUSIONS: In contrast to recent literature, direct-current cardioversion proved to be an ineffective method for treatment of new-onset supraventricular tachyarrhythmias and, in particular, atrial fibrillation with a rapid ventricular response in surgical intensive care unit patients.

Adult↗

PubMed2003

CrossNets: high-performance neuromorphic architectures for CMOL circuits.

The exponential, Moore's Law, progress of electronics may be continued beyond the 10-nm frontier if the currently dominant CMOS technology is replaced by hybrid CMOL circuits combining a silicon MOSFET stack and a few layers of parallel nanowires connected by self-assembled molecular electronic devices. Such hybrids promise unparalleled performance for advanced information processing, but require special architectures to compensate for specific features of the molecular devices, including low voltage gain and possible high fraction of faulty components. Neuromorphic networks with their defect tolerance seem the most natural way to address these problems. Such circuits may be trained to perform advanced information processing including (at least) effective pattern recognition and classification. We are developing a family of distributed crossbar network (CrossNet) architectures that permit the combination of high connectivity neuromorphic circuits with high component density. Preliminary estimates show that this approach may eventually allow us to place a cortex-scale circuit with about 10(10) neurons and about 10(14) synapses on an approximately 10 x 10 cm(2) silicon wafer. Such systems may provide an average cell-to-cell latency of about 20 nsec and, thus, perform information processing and system training (possibly including self-evolution after initial training) at a speed that is approximately six orders of magnitude higher than in its biological prototype and at acceptable power dissipation.

Biomimetic Materials↗

PubMed2003

Early identification of bacteria leading to central venous catheter contamination.

UNLABELLED: Catheter-related bloodstream infections (CRBSI) are a common problem in patients after central venous catheterization. Using DNA analysis we compared bacteria found on the tip of central venous catheters removed because of clinical signs of CRBSI with bacteria found on needle, dilator, and guidewire used for insertion of these catheters. In five of seven central venous catheters removed because of clinical signs of CRBSI, bacteria on the catheter tip were genetically identical to bacteria found on the insertion device, proving that catheter contamination in these cases was caused by contacting bacteria during the initial puncture. These findings may be important for antibiotic prophylaxis or therapy in patients at risk for CRBSI. IMPLICATIONS: In five of seven central venous catheters removed because of clinical signs of catheter-related blood infections, DNA analysis showed bacteria found on the catheter tip to be identical with bacteria found on the puncture kits used for insertion of these catheters.

Bacterial Infections↗

PubMed2002

Jejunal tissue oxygenation and microvascular flow motion during hemorrhage and resuscitation.

The relationship between flow motion and tissue oxygenation was investigated during hemorrhage/retransfusion with and without dopamine in 14 pigs. During 45% bleed, jejunal microvascular hemoglobin O(2) saturation (HBjO(2)) and mucosal tissue Po(2) (Po(2)muc) were recorded in seven control and seven dopamine-treated animals. Mean arterial pressure and systemic O(2) delivery decreased during hemorrhage and returned to baseline after retransfusion. Hemorrhage decreased Po(2)muc from 33 +/- 2.8 to 13 +/- 1.6 mmHg and HBjO(2) from 53 +/- 4.9% to 32 +/- 3.9%, respectively, in control animals. During reperfusion, Po(2)muc and HBjO(2) remained low. Dopamine increased Po(2)muc from 28 +/- 4.3 to 45 +/- 4.6 mmHg and HBjO(2) from 54 +/- 5.7% to 69 +/- 1.5% and attenuated the decrease in Po(2)muc and HBjO(2) during hemorrhage. After retransfusion, dopamine restored Po(2)muc and HBjO(2) to baseline. Control animals developed rhythmic HBjO(2) oscillations with increasing amplitude (frequency, 4.5 to 7.6 cycles/min) and showed an inverse relationship between Po(2)muc and HBjO(2) oscillation amplitude. Dopamine prevented regular flow motion. The association between decreased Po(2)muc and increased oscillations in HBjO(2) after normalization of systemic hemodynamics and O(2) transport in control animals suggests a cause-and-effect relationship between low tissue Po(2) and flow motion activity within the jejunal microcirculation.

Animals↗

PubMed2002

Factors influencing intensive care unit length of stay after surgery for acute aortic dissection type A.

BACKGROUND: Operative mortality after acute aortic dissection type A is still high, and prolonged stay at the intensive care unit is common. Little has been documented about factors influencing the intensive care unit length of stay. The aim of this study was to determine such variables. METHODS: During a 10-year period, 67 patients (47 male, 20 female) were operated on for acute aortic dissection type A. In 42 patients (63%), an ascending aortic replacement was performed, 23 patients (34%) underwent a Bentall procedure, and 2 patients (3%) received a valve-sparing David type of operation. In 14 of these cases (20%), an additional partial or total arch replacement was performed. RESULTS: Hospital mortality was 9 of 67 (14%). Median postoperative intensive care unit length of stay was 5 days (range, 1 to 72 days). Intensive care unit stay was in univariate analysis significantly influenced by the following factors: age (p = 0.008), body mass index (p = 0.039), cardiopulmonary bypass time (p = 0.018), aortic cross-clamp time (p = 0.031), postoperative low cardiac output syndrome (p < 0.001), and postoperative lactate levels (p = 0.01). By multivariate analysis, age (p = 0.012), cardiopulmonary bypass time (p = 0.037), and the presence of a postoperative low cardiac output syndrome (p < 0.001) significantly influenced intensive care unit stay. CONCLUSIONS: Stay in the intensive care unit after operation for acute aortic dissection type A seems to be determined by age, cardiopulmonary bypass time, and the postoperative presence of a low cardiac output syndrome.

Adolescent↗

PubMed1999

Metal Complexes of Pyridylphenylisocyanides and Pyridylethynylphenylisocyanides as Building Blocks for Coordination Polymers and Supramolecular Assemblies.

The isocyanides 3-(4-pyridylethynyl)phenylisocyanide, 3, 4-(4-pyridylethynyl)phenylisocyanide, 6, 2,6-diisopropyl-4-(4-pyridylethynyl)phenylisocyanide, 9, and 2,6-diisopropyl-4-(4-pyridyl)phenylisocyanide, 11, were prepared. With PdI(2) and PtI(2), these isocyanides form the complexes trans-[MI(2)(CNR)(2)], 12-19 (M = Pd, Pt; CNR = 3, 6, 9, 11). The previously prepared complex trans-[PdI(2)(CNC(5)H(4)N-3)(2)] and trans-[PdI(2)(CNC(6)H(2)-(i-Pr)(2)-2,6-(CC-C(5)H(4)N-4)-4)(2)], 16, combine with copper bis(trifluoroacetylacetonate) in the ratio of 1:2 to form the adducts trans-[PdI(2)(CNC(5)H(4)N-3)(2)].2[Cu(tfacac)(2)].2CH(2)Cl(2), 20, and trans-[PdI(2)(CNC(6)H(2)-(i-Pr)(2)-2,6-(CC-C(5)H(4)N-4)-4)(2)].2[Cu(tfacac)(2)], 21, respectively. The complexes trans-[MI(2)(CNC(6)H(2)-(i-Pr)(2)-2,6-(C(5)H(4)N-4)-4)(2)], 19 (M = Pd) and 20 (M = Pt), react with [Pd(SO(3)CF(3))(2)(dppp)] (dppp = bisdiphenylphosphinopropane) to form the molecular squares [Pd(dppp)(trans-[MI(2)(CNC(6)H(2)-(i-Pr)(2)-2,6-(C(5)H(4)N-4)-4)(2)](4)(SO(3)CF(3))(8), 22 (M = Pd) and 23 (M = Pt). The crystal structure of 20 has been determined by X-ray crystallography. 20: C(34)H(28)Cl(4)Cu(2)F(12)I(2)N(4)O(8)Pd, monoclinic space group, P2(1)/n (No. 14), a = 10.899(3) Å, b = 13.903(1) Å, c = 17.827(6) Å, beta = 105.50(2) degrees, Z = 2, 2618 unique reflections, R = 0.093, R(w) = 0.091.

Journal Article↗

PubMed1996

Transition Metal Complexes of Cyanoisocyanoarenes as Building Blocks for One-, Two-, and Three-Dimensional Molecular Solids.

The complexes trans-[MI(2)(CNC(6)H(4)-CN-4)(2)], (M = Pd and Pt), trans-[FeI(2)L(4)] (L = CNC(6)H(4)-CN-4 and CNC(6)H(2)-Me(2)-2,6-CN-4), and [Mn(CNC(6)H(4)-CN-4)(6)][SO(3)CF(3)] were prepared. The compounds are thermally stable up to 230 degrees C or higher. The molecular structure of trans-[FeI(2)(CNC(6)H(4)-CN-4)(4)] was determined by X-ray crystallography: monoclinic, space group P2(1)/n, a = 11.570(2) Å, b = 10.1052(8) Å, c = 28.138(7) Å, beta = 92.034(9) degrees, Z = 4, 3464 unique reflections, R = 0.074, R(w) = 0.089. The complexes contain the peripheral cyano groups in linear, planar, and octahedral dispositions, respectively. Solids were obtained by combining solutions of [PdI(2)(CNC(6)H(4)-CN-4)(2)] and [Cu(hfacac)(2)], [FeI(2)(CNC(6)H(4)-CN-4)(4)] and AgSO(3)CF(3), [FeI(2)(CNC(6)H(2)-Me(2)-2,6-CN-4)(4)] and [Rh(2)(O(2)CCF(3))(4)], and [Mn(CNC(6)H(4)-CN-4)(6)][SO(3)CF(3)] and [Rh(2)(O(2)CCF(3))(4)]. [PdI(2)(CNC(6)H(4)-CN-4)(2)] and [Cu(hfacac)(2)] in a ratio of 1:2 form a crystalline, one-dimensional solid: monoclinic, space group P2(1)/c, a = 8.317(2) Å, b = 13.541(1) Å, c = 22.568(5) Å, beta = 100.45(1) degrees, Z = 2, 3279 unique reflections, R = 0.037, R(w) = 0.047.

Journal Article↗