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Andreas Munk Petersen

Publications and source records attributed to Andreas Munk Petersen.

4 recordsLinked to original sources
PubMed2006

[Clostridium difficile-associated diarrhoea--a changing disease?].

In recent years an increase in the number of Clostridium difficile-associated diarrhoea cases has been reported worldwide. This is due mainly to the increasing number of elderly patients being admitted to hospitals, changes in hygiene standards and changes in the antibiotics used to combat other diseases. But changes in the virulence of C. difficile strains also seem to play a role. This review presents the current knowledge of C. difficile-associated diarrhoea in the light of these changes in incidence and virulence.

Clostridioides difficile↗
PubMed2004

Virulence factors for hemolytic uremic syndrome, Denmark.

We present an analysis of strain and patient factors associated with the development of bloody diarrhea and hemolytic uremic syndrome (HUS) among Shiga toxin-producing Escherichia coli (STEC) patients registered in Denmark in a 6-year period. Of 343 STEC patients, bloody diarrhea developed in 36.4% and HUS in 6.1%. In a multivariate logistic regression model, risk factors for bloody diarrhea were the eae and stx2 genes, O groups O157 and O103, and increasing age. Risk factors for HUS were presence of the stx2 (odds ratio [OR] 18.9) and eae (OR undefined) genes, being a child, and having bloody diarrhea. O group O157, although associated with HUS in a univariate analysis (OR 4.0), was not associated in the multivariate analysis (OR 1.1). This finding indicates that, rather than the O group, the combined presence of the eae and stx2 genes is an important predictor of HUS.

Adhesins, Bacterial↗
PubMed2003

Helicobacter pylori: an invading microorganism? A review.

In this review we evaluate the pros and cons of Helicobacter pylori invasion of epithelial cells as part of the natural history of H. pylori infection. H. pylori is generally considered an extracellular microorganism. However, a growing body of evidence supports the controversial hypothesis that at least a subset of H. pylori microorganisms has an intracellular (intraepithelial) location. Most significant is the fact that H. pylori invades cultured epithelial cells with invasion frequencies similar to Yersinia enterocolitica and better than Shigella flexneri; furthermore, studies of invasion mechanisms suggest that H. pylori invasion of and survival within epithelial cells is not merely a passive event, but requires active participation of the microorganism. Although many studies of human gastric biopsy specimens have failed to demonstrate any intracellular H. pylori, some studies have revealed a minor fraction of H. pylori inside gastric epithelial cells, with possible linkage to peptic ulceration and epithelial cell damage. In conclusion, these data encourage further research to establish whether intracellular H. pylori does play a role in H. pylori colonization of the human stomach and in peptic ulcer pathogenesis.

Cell Line↗