Biomedical subjects

Andrew Dimitrijevic

Publications and source records attributed to Andrew Dimitrijevic.

5 recordsLinked to original sources

PubMed2003

Human auditory steady-state responses.

Steady-state evoked potentials can be recorded from the human scalp in response to auditory stimuli presented at rates between 1 and 200 Hz or by periodic modulations of the amplitude and/or frequency of a continuous tone. Responses can be objectively detected using frequency-based analyses. In waking subjects, the responses are particularly prominent at rates near 40 Hz. Responses evoked by more rapidly presented stimuli are less affected by changes in arousal and can be evoked by multiple simultaneous stimuli without significant loss of amplitude. Response amplitude increases as the depth of modulation or the intensity increases. The phase delay of the response increases as the intensity or the carrier frequency decreases. Auditory steady-state responses are generated throughout the auditory nervous system, with cortical regions contributing more than brainstem generators to responses at lower modulation frequencies. These responses are useful for objectively evaluating auditory thresholds, assessing suprathreshold hearing, and monitoring the state of arousal during anesthesia.

Acoustic Stimulation↗

PubMed2002

Auditory steady-state responses to exponential modulation envelopes.

OBJECTIVE: This study examined the steady-state responses evoked by tones modulated with exponential envelopes. The hypothesis was that stimuli with envelopes containing more rapid changes would evoke larger responses. DESIGN: Multiple auditory steady-state responses were recorded simultaneously to eight tonal stimuli, four in each ear. The carrier frequencies of the stimuli ranged from 500 to 6000 Hz and the modulation rates were between 75 and 95 Hz. The modulation envelopes were based on functions using sin' where N was 1, 2, 3, or 4. Setting N to 1 produced the traditional sinusoidal modulation. RESULTS: Exponential envelopes with N greater than 1 produced larger steady-state responses than a sinusoidal envelope. For amplitude-modulation (AM), exponential envelopes increased response amplitudes by 21% at 55 dB pSPL, and by 29% at 35 dB pSPL. The increases were smaller for carrier frequencies of 1500 to 2000 Hz than for lower and higher carrier frequencies. Latencies calculated from phase data increased significantly with increasing N. This was likely caused by the point of maximal envelope-slope shifting later in time as N increased. For frequency modulation (FM), the steady-state responses did not significantly change with changes in the power of the exponential envelopes. CONCLUSIONS: When tones are amplitude-modulated with exponential envelopes based on sin(N), the amplitude and latency of the steady-state response increased significantly with increasing N. Using exponential envelopes with N greater than 1 should considerably shorten the time needed for responses to become significant when using steady-state responses in objective audiometry.

Adult↗

PubMed2002

Multiple auditory steady-state responses.

Steady-state responses are evoked potentials that maintain a stable frequency content over time. In the frequency domain, responses to rapidly presented stimuli show a spectrum with peaks at the rate of stimulation and its harmonics. Auditory steady-state responses can be reliably evoked by tones that have been amplitude-modulated at rates between 75 and 110 Hz. These responses show great promise for objective audiometry, because they can be readily recorded in infants and are unaffected by sleep. Responses to multiple tones presented simultaneously can be independently assessed if each tone is modulated at a different modulation frequency. This ability makes it possible to estimate thresholds at several audiometric frequencies in both ears at the same time. Because amplitude-modulated tones are not significantly distorted by free-field speakers or microphones, they can also be used to evaluate the performance of hearing aids. Responses to amplitude and frequency modulation may also become helpful in assessing suprathreshold auditory processes, such as those necessary for speech perception.

Age Factors↗

PubMed2002

Estimating the audiogram using multiple auditory steady-state responses.

Multiple auditory steady-state responses were evoked by eight tonal stimuli (four per ear), with each stimulus simultaneously modulated in both amplitude and frequency. The modulation frequencies varied from 80 to 95 Hz and the carrier frequencies were 500, 1000, 2000, and 4000 Hz. For air conduction, the differences between physiologic thresholds for these mixed-modulation (MM) stimuli and behavioral thresholds for pure tones in 31 adult subjects with a sensorineural hearing impairment and 14 adult subjects with normal hearing were 14+/-11, 5+/-9, 5+/-9, and 9+/-10 dB (correlation coefficients .85, .94, .95, and .95) for the 500-, 1000-, 2000-, and 4000-Hz carrier frequencies, respectively. Similar results were obtained in subjects with simulated conductive hearing losses. Responses to stimuli presented through a forehead bone conductor showed physiologic-behavioral threshold differences of 22+/-8, 14+/-5, 5+/-8, and 5+/-10 dB for the 500-, 1000-, 2000-, and 4000-Hz carrier frequencies, respectively. These responses were attenuated by white noise presented concurrently through the bone conductor.

Adult↗

PubMed2002

Advantages and caveats when recording steady-state responses to multiple simultaneous stimuli.

This article considers the efficiency of evoked potential audiometry using steady-state responses evoked by multiple simultaneous stimuli with carrier frequencies at 500, 1000, 2000, and 4000 Hz. The general principles of signal-to-noise enhancement through averaging provide a basis for determining the time required to estimate thresholds. The advantage of the multiple-stimulus technique over a single-stimulus approach is less than the ratio of the number of stimuli presented. When testing two ears simultaneously, the advantage is typically that the multiple-stimulus technique is two to three times faster. One factor that increases the time of the multiple-response recording is the relatively small size of responses at 500 and 4000 Hz. Increasing the intensities of the 500- and 4000-Hz stimuli by 10 or 20 dB can enhance their responses without significantly changing the other responses. Using multiple simultaneous stimuli causes small changes in the responses compared with when the responses are evoked by single stimuli. The clearest of these interactions is the attenuation of the responses to low-frequency stimuli in the presence of higher-frequency stimuli. Although these interactions are interesting physiologically, their small size means that they do not lessen the advantages of the multiple-stimulus approach.

Audiometry, Pure-Tone↗