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Biomedical subjects

Andrew Hayward

Publications and source records attributed to Andrew Hayward.

9 recordsLinked to original sources
PubMed2006

Influenza immunisation: attitudes and beliefs of UK healthcare workers.

AIM: To explore attitudes to influenza immunisation and rates of uptake among staff working in acute hospitals in the UK. METHOD: A cross-sectional survey of 11,670 healthcare workers in six UK hospitals was carried out using a postal questionnaire. RESULTS: Among 6302 responders (54% of those mailed), 19% had taken up influenza immunisation during winter 2002/3. Vaccination was well tolerated, with a low prevalence of side effects (13%) and associated time off work (2%). The majority of subjects who accepted vaccination (66%) were most strongly influenced by the personal benefits of protection against influenza. Prevention of sickness absence and protection of patients were the prime motivation for only 10% and 7% of subjects, respectively. Among 3967 who declined vaccination, the most common primary demotivators were concern about safety (31%) and efficacy (29%). 22% were most strongly deterred by lack of time to attend for vaccination. Free text answers indicated that 37% declined because of a perceived low ratio of personal benefits to adverse effects. Subjects said they would be persuaded to take up vaccination in future by easier access (36%), more information about personal benefit and risk (34%) and more information about effects on staff absence (24%). CONCLUSIONS: These findings indicate that the uptake of influenza immunisation among UK healthcare workers remains low. There is some scope for increasing uptake by improving accessibility and encouragement from professional peers. However, the results suggest that perception of small personal benefit in relation to risk mitigates, importantly, against higher uptake of routine annual influenza vaccination. Thus, resource might better be allocated to ensuring efficient management in epidemic years. The effect of publicity about pandemic influenza on risk perception and vaccine uptake among healthcare workers during winter 2005/6 warrants further study.

Absenteeism↗
PubMed2006

Incidence of Guillain-Barré syndrome among patients with Campylobacter infection: a general practice research database study.

The association between Campylobacter infection and subsequent Guillain-Barré syndrome (GBS) has been well documented. To date, however, there exists no direct estimate of the incidence of GBS among patients with Campylobacter infection. Using the General Practice Research Database, we estimate the incidence of GBS in a cohort of patients presenting with Campylobacter enteritis to be 1.17/1000 person-years, a rate 77 times greater than that in the general population. The probability that an individual who develops Campylobacter enteritis will also develop GBS during the subsequent 2-month period is <2/10,000.

Adult↗
PubMed2005

Transfer of spatial behaviour controlled by a landmark array with a distinctive shape.

In two experiments, rats swam to a submerged platform in one corner of a rectangular or kite-shaped array created by four identical landmarks attached to the walls of a circular pool. After training in the rectangular array, rats expressed a preference for the corner in the kite-shaped array that was geometrically equivalent to where the platform was located previously. After training in either array, the removal of two landmarks from the rectangular array, or the landmark at the apex of the kite-shaped array, did not affect the control over searching exerted by the remaining landmarks. The results imply that rats use local rather than global spatial representations when searching for a hidden goal with reference to an array of landmarks.

Animals↗
PubMed2004

Failure of a landmark to restrict spatial learning based on the shape of the environment.

Rats were required to find a submerged platform in the corner of a swimming pool with a distinctive shape. A landmark near the platform did not interfere with the control acquired by the pool's shape over searching for the platform. This outcome was observed with an overshadowing and a blocking design. A comparison of the ease with which the landmark and the pool's shape gained control over searching for the platform indicates that the failure of overshadowing and blocking was not a consequence of the landmark being less salient than the shape of the pool. The results are not readily explained by theories of associative learning, but they are consistent with the claim that learning about the shape of the environment takes place in a dedicated module, which excludes information about the significance of individual landmarks.

Animals↗
PubMed2003

Absence of overshadowing and blocking between landmarks and the geometric cues provided by the shape of a test arena.

In three experiments rats were required to escape from a pool of water by swimming to a submerged platform. The position of the platform was determined by the shape of the pool, which was either rectangular or triangular. A landmark that was located on the surface of the pool near the platform failed to overshadow (Experiment 1) or block (Experiment 2) learning about the position of the platform with reference to the shape of the pool. Experiment 3 revealed a similar outcome with cues outside the pool, which could be used, in addition to the shape of the pool, to identify the location of the platform. These findings imply that theories of learning that assume that stimuli must compete with each other for the control that they acquire may not apply to spatial learning based on the shape of the environment.

Association Learning↗
PubMed2002

Functional benefits and cost/benefit analysis of continuous intrathecal baclofen infusion for the management of severe spasticity.

OBJECT: Intrathecally delivered baclofen has been used as a treatment for severe spasticity since 1984. Despite this, there are uncertainties surrounding the benefits of treatment and the costs involved. The authors assessed the evidence of benefits and identified costs and the cost/benefit ratio for continuous intrathecal baclofen infusion in the treatment of severe spasticity. METHODS: A systematic literature review was conducted to estimate the effect of continuous intrathecal baclofen infusion on function and quality-of-life (QOL) measures in patients with severe spasticity. Outcomes were related to standard QOL scores to estimate potential gains in quality-adjusted life years (QALYs). Information on the costs of continuous intrathecal baclofen infusion was obtained from hospitals in the United Kingdom. This information was combined to estimate the cost/benefit ratio for the use of continuous intrathecal baclofen infusion in patients with different levels of disability from severe spasticity. Studies indicate that bedbound patients are likely to improve their mobility and become able to sit out of bed. Patients with severe spasm-related pain are likely to have major improvement or complete resolution of this pain. Many other benefits are also reported. Such benefits are related to costs per QALY in the range of 6,900 pounds to 12,800 pounds ($10,550-$19,570 US). CONCLUSIONS: In carefully selected patients who have not responded to less invasive treatments, continuous intrathecal baclofen infusion is likely to lead to worthwhile functional benefits. Continuous intrathecal baclofen infusion has an acceptable cost/benefit ratio compared with other interventions that are funded by the health service.

Adolescent↗