Biomedical subjects

Andrew R C Kelso

Publications and source records attributed to Andrew R C Kelso.

2 recordsLinked to original sources

PubMed2006

Antiepileptic effect of gap-junction blockers in a rat model of refractory focal cortical epilepsy.

PURPOSE: Epilepsy is the most common serious neurologic disease, and current treatments are ineffective for or=1 h before drug infusion and for >or=3 h afterward. No ill effects were observed. RESULTS: An immediate and marked reduction in percentage of seizure time was seen in rats receiving carbenoxolone (baseline, 69.4%+/- 7.0% (SEM); maximum effect, 9.3%+/- 3.5%, p <or=0.001) and meclofenamic acid (baseline, 58.3%+/- 3.7%; maximum effect, 0.92%+/- 0.92%, p < 0.001). No effect was seen after saline infusion. CONCLUSIONS: Gap-junction blockers applied focally are effective at suppressing seizures and, as such, represent a potential new treatment for epilepsy. Development of focal treatment strategies is essential in this regard.

Administration, Topical↗

PubMed2005

Advances in epilepsy.

Advances in understanding of both the causes and consequences of epilepsy have been paralleled by a number of recent reports and clinical guidelines highlighting the complexities involved in both diagnosing and treating epilepsy. We review recent developments, including comments on the evolution of clinical guidelines, anti-epileptic drugs, epilepsy surgery and new treatment approaches in development. Epilepsy genetics and emerging evidence on mechanisms of drug resistance in epilepsy will also be discussed. Issues with respect to pregnancy and epilepsy are considered, together with more recently identified dilemmas including bone health in epilepsy and whether seizures themselves cause brain damage. Imaging in epilepsy has recently been reviewed elsewhere, and will not be discussed.

Anticonvulsants↗