Biomedical subjects

Andrew R Jones

Publications and source records attributed to Andrew R Jones.

4 recordsLinked to original sources

PubMed2006

A strategy capitalizing on synergies: the Reporting Structure for Biological Investigation (RSBI) working group.

In this article we present the Reporting Structure for Biological Investigation (RSBI), a working group under the Microarray Gene Expression Data (MGED) Society umbrella. RSBI brings together several communities to tackle the challenges associated with integrating data and representing complex biological investigations, employing multiple OMICS technologies. Currently, RSBI includes environmental genomics, nutrigenomics and toxicogenomics communities, where independent activities are underway to develop databases and establish data communication standards within their respective domains. The RSBI working group has been conceived as a "single point of focus" for these communities, conforming to general accepted view that duplication and incompatibility should be avoided where possible. This endeavour has aimed to synergize insular solutions into one common terminology between biologically driven standardisation efforts and has also resulted in strong collaborations and shared understanding between those in the technological domain. Through extensive liaisons with many standards efforts, several threads have been woven with the hope that ultimately technology-centered standards and their specific extensions into biological domains of interest will not only stand alone, but will also be able to function together, as interchangeable modules.

Databases, Genetic↗

PubMed2006

FuGE: Functional Genomics Experiment Object Model.

This is an interim report on the Functional Genomics Experiment (FuGE) Object Model. FuGE is a framework for creating data standards for high-throughput biological experiments, developed by a consortium of researchers from academia and industry. FuGE supports rich annotation of samples, protocols, instruments, and software, as well as providing extension points for technology specific details. It has been adopted by microarray and proteomics standards bodies as a basis for forthcoming standards. It is hoped that standards developers for other omics techniques will join this collaborative effort; widespread adoption will allow uniform annotation of common parts of functional genomics workflows, reduce standard development and learning times through the sharing of consistent practice, and ease the construction of software for accessing and integrating functional genomics data.

Computer Simulation↗

PubMed2005

An analysis of extensible modelling for functional genomics data.

BACKGROUND: Several data formats have been developed for large scale biological experiments, using a variety of methodologies. Most data formats contain a mechanism for allowing extensions to encode unanticipated data types. Extensions to data formats are important because the experimental methodologies tend to be fairly diverse and rapidly evolving, which hinders the creation of formats that will be stable over time. RESULTS: In this paper we review the data formats that exist in functional genomics, some of which have become de facto or de jure standards, with a particular focus on how each domain has been modelled, and how each format allows extensions. We describe the tasks that are frequently performed over data formats and analyse how well each task is supported by a particular modelling structure. CONCLUSION: From our analysis, we make recommendations as to the types of modelling structure that are most suitable for particular types of experimental annotation. There are several standards currently under development that we believe could benefit from systematically following a set of guidelines.

Chemistry Techniques, Analytical↗

PubMed1996

Transcutaneous electric nerve stimulation (TENS) during distension shoulder arthrography: a controlled trial.

Transcutaneous electric nerve stimulation (TENS) is a safe and simple form of analgesia but is little used as an adjunct to local anaesthesia during routine procedures. This trial investigates the use of TENS in the radiology department using distension shoulder arthrography for 'frozen shoulder', a moderately painful procedure, as a model. Sixty patients with a clinical diagnosis of 'frozen shoulder' were randomised to receive high-intensity TENS, low-intensity TENS or to act as controls. A standard procedure was then performed. Following the procedure patients completed a visual analogue pain scale. Mean recorded pain levels were lower in the TENS groups with a 50% difference between the high-intensity group and a 38% difference between the low-intensity group as compared to control (difference statistically significant P < 0.01 and P < 0.05, respectively). TENS was well tolerated by patients. The 50% reduction in mean pain levels supports the use of TENS for routine painful procedures.

Adult↗