Requirements for high impact diagnostics in the developing world.
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Biomedical subjects
Publications and source records attributed to Andrew Shepherd.
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In this study, the flow and rheology of pre-collapse Larsen B ice shelf are investigated by using a combination of flow modelling and data assimilation. Observed shelf velocities from satellite interferometry are used to constrain an ice shelf model by using a data assimilation technique based on the control method. In particular, the ice rheology field and the velocities at the inland shelf boundary are simultaneously optimized to get a modelled flow and stress field that is consistent with the observed flow. The application to the Larsen B ice shelf shows that a strong weakening of the ice in the shear zones, mostly along the margins, is necessary to fit the observed shelf flow. This pattern of bands with weak ice is a very robust feature of the inversion, whereas the ice rheology within the main shelf body is found to be not well constrained. This suggests that these weak zones play a major role in the control of the flow of the Larsen B ice shelf and may be the key to understanding the observed pre-collapse thinning and acceleration of Larsen B. Regarding the sensitivity of the stress field to rheology, the consistency of the model with the observed flow seems crucial for any further analysis such as the application of fracture mechanics or perturbation model experiments.
The existence of many subglacial lakes provides clear evidence for the widespread presence of water beneath the East Antarctic ice sheet, but the hydrology beneath this ice mass is poorly understood. Such knowledge is critical to understanding ice flow, basal water transfer to the ice margin, glacial landform development and subglacial lake habitats. Here we present ice-sheet surface elevation changes in central East Antarctica that we interpret to represent rapid discharge from a subglacial lake. Our observations indicate that during a period of 16 months, 1.8 km3 of water was transferred over 290 km to at least two other subglacial lakes. While viscous deformation of the ice roof above may moderate discharge, the intrinsic instability of such a system suggests that discharge events are a common mode of basal drainage. If large lakes, such as Lake Vostok or Lake Concordia, are pressurizing, it is possible that substantial discharges could reach the coast. Our observations conflict with expectations that subglacial lakes have long residence times and slow circulations, and we suggest that entire subglacial drainage basins may be flushed periodically. The rapid transfer of water between lakes would result in large-scale solute and microbe relocation, and drainage system contamination from in situ exploration is, therefore, a distinct risk.
Notch signaling is used to specify cell types during animal development. A high level specifies one cell type, whereas a low level specifies the alternate type. The effector of Notch signaling is the Notch intracellular domain. Upon its release from the plasma membrane in response to Delta binding the Notch extracellular domain, the Notch intracellular domain combines with the transcription factor Suppressor of Hairless and promotes the expression of target genes. Using a panel of antibodies made against different extracellular and intracellular regions of Notch, we show that cell types and tissues with low levels of Notch signaling are enriched for Notch molecules detected only by the extracellular domain antibodies. This enrichment often follows enrichment for Notch molecules detected only by antibodies made against the Suppressor of Hairless binding region. Notch molecules lacking most of the intracellular domain or containing only the Suppressor of Hairless binding region are produced during development. Such molecules are known to suppress Notch signaling, possibly by taking away Delta or Suppressor of Hairless from the full-length Notch. Thus, it is possible that dominant-negative Notch molecules are produced in the normal course of tissue differentiation in Drosophila as part of an auto-down-regulation mechanism.
Human error is often related to flaws in system design which might have been avoided had greater attention been paid to human factors knowledge and methods as the system was developed. The paper considers the role of human factors in system design and argues that adopting an operational perspective in identifying human factors issues ensures that subsequent human factors advice is focused upon real needs and is consistent with how managers and engineers choose to manage their systems. It also considers the issue of timeliness of human factors input. Failure to consider human factors issues at a time when other design decisions are being taken often means that it is less straightforward to accommodate changes. Thus, managers and engineers may resist dealing effectively with potential human factors problems for reasons of cost and delay in meeting project milestones.
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The retreat and collapse of Antarctic Peninsula ice shelves in tandem with a regional atmospheric warming has fueled speculation as to how these events may be related. Satellite radar altimeter measurements show that between 1992 and 2001 the Larsen Ice Shelf lowered by up to 0.27 +/- 0.11 meters per year. The lowering is explained by increased summer melt-water and the loss of basal ice through melting. Enhanced ocean-driven melting may provide a simple link between regional climate warming and the successive disintegration of sections of the Larsen Ice Shelf.