High activity of rituximab combined with cladribine and cyclophosphamide in a patient with pulmonary lymphomatoid granulomatosis and bone marrow involvement.
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Antibodies, Monoclonal↗
Biomedical subjects
Andrzej Bednarek
Publications and source records attributed to Andrzej Bednarek.
[Chiari pelvic osteotomy in the treatment of hip dysplasia in adults].
INTRODUCTION: [corrected] The aim of the study is early results evaluation of Chiari pelvic osteotomy. MATERIALS AND METHODS: In the years 1997-2003 36 patients (26 women and 10 men) in the age from 16 to 50 years old were operated on because of hip joint dysplasia. The indications for operative treatment were: pain, age less than 50 years, insufficient femoral head coverage without evidence of arthritic changes on X-ray. RESULTS: There were no intraoperative and postoperative complications. Harris Hip Score improved from 85 points before operation (from 82 to 90 pts.) to 95 points (from 92 to 100 pts.) after operative treatment. There was pain relief in most of the patients after osteotomy. Osteotomy healing was seen on X-ray examination usually after 6-12 weeks in 33 patients. Delayed osteotomy union till 6th postoperative month without influence on clinical hip improvement was seen in 3 patients. The increase in Wiberg CE angle from average 17.2 degrees (from 3 to 33 degrees) before operation to 44.9 degrees (from 19 to 78 degrees) after operation was statistically significant p< 0.00045. There was no loss in osteotomy correction. CONCLUSION: Supraacetabular osteotomy decreases pain, and increases hip function. Improvement in hip biomechanics and increase in femoral head coverage may lead to decrease in development of hip joint arthritic changes and time preserve before total hip arthroplasty.
Adolescent↗
A protein-domain microarray identifies novel protein-protein interactions.
Protein domains mediate protein-protein interactions through binding to short peptide motifs in their corresponding ligands. These peptide recognition modules are critical for the assembly of multiprotein complexes. We have arrayed glutathione S-transferase (GST) fusion proteins, with a focus on protein interaction domains, on to nitrocellulose-coated glass slides to generate a protein-domain chip. Arrayed protein-interacting modules included WW (a domain with two conserved tryptophans), SH3 (Src homology 3), SH2, 14.3.3, FHA (forkhead-associated), PDZ (a domain originally identified in PSD-95, DLG and ZO-1 proteins), PH (pleckstrin homology) and FF (a domain with two conserved phenylalanines) domains. Here we demonstrate, using peptides, that the arrayed domains retain their binding integrity. Furthermore, we show that the protein-domain chip can 'fish' proteins out of a total cell lysate; these domain-bound proteins can then be detected on the chip with a specific antibody, thus producing an interaction map for a cellular protein of interest. Using this approach we have confirmed the domain-binding profile of the signalling molecule Sam68 (Src-associated during mitosis 68), and have identified a new binding profile for the core small nuclear ribonucleoprotein SmB'. This protein-domain chip not only identifies potential binding partners for proteins, but also promises to recognize qualitative differences in protein ligands (caused by post-translational modification), thus getting at the heart of signal transduction pathways.
Amino Acid Sequence↗