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Biomedical subjects

Anita Panda

Publications and source records attributed to Anita Panda.

At least 19 recordsLinked to original sources
PubMed2007

Unilateral congenital corneal keloid with anterior segment mesenchymal dysgenesis and subluxated lens: case report and review of literature.

PURPOSE: To report the unusual association of unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens. METHODS: A 20-year old man presented with a mass lesion involving the left cornea. The corneal lesion had been present since birth. On biomicroscopic examination, a well-defined vascularized, grayish-white mass occupying the whole of the left cornea was seen. The right eye showed multiple peripheral corneal opacities with iridocorneal adhesions, a poorly defined supranasal limbus, and a subluxated lens. Excision biopsy of the mass was done for histopathologic examination. RESULTS: Histopathologic examination of the excised corneal mass showed features consistent with that of a corneal keloid: thickened keratinized epithelium, absent Bowman membrane layer, and fibrovascular hyperplasia composed of hyalinized collagen fibers with irregular orientation of the collagen lamellae. During penetrating keratoplasty of the left eye, an anomalous iris pattern with poorly defined angle and a supranasal subluxated lens was also observed. Extraction of the subluxated lens was also done. The graft failed subsequent to a nonhealing persistent epithelial defect. CONCLUSION: Our case report highlights the rare association of a unilateral congenital corneal keloid with anterior-segment mesenchymal dysgenesis and bilateral subluxated lens.

Adult↗
PubMed2006

The efficacy of postenucleation saline wash and the effect of different antimicrobial agents on microbial contamination of donor eyes.

OBJECTIVES: To evaluate the efficacy of postenucleation saline wash and the effect of different antimicrobial agents on the microbial contamination of donor eyes. METHODS: Two hundred donor eyes were given saline wash and treated with any one of the following 5 randomly selected antimicrobial solutions: 1% povidone-iodine for 3 min, 0.3% gentamycin for 10 min, 0.3% ciprofloxacin for 10 min, a combination of neomycin 1,700 IU, gramicidin 0.025% and polymyxin B 5,000 IU (Neosporin(R)) for 10 min and a combination of 0.3% amikacin for 10 min, followed by 2.5% cefazolin for 10 min. Limbal swabs were sent for culture before and after saline wash and after treatment with antimicrobial agents. RESULTS: On culture of the pretreatment swabs, 77.5% were positive for growth with 75.5% bacterial and 11.5% fungal. Coagulase-negative Staphylococcus (29.1%) was the most common bacterial contamination followed by Pseudomonas aeruginosa (18.5%), Acinetobacter sp. (18.5%) and Alcaligenes faecalis (13.2%). A 20-ml sterile saline wash resulted in a 20% decrease (p < 0.01) in the amount of contamination. The maximum antimicrobial effect with regard to bacterial decontamination was achieved with povidone-iodine (64% decrease in the amount of contamination, p < 0.01) followed by ciprofloxacin (47.6% decrease, p < 0.05), the combination of cefazolin and amikacin (42.5%, p < 0.05), Neosporin (38.5%, p < 0.05) and then gentamycin (21.7%, p = NS). CONCLUSIONS: A thorough saline wash and treatment with 1% povidone-iodine for 3 min is a more effective method for the decontamination of donor eyes as compared to most currently available and frequently used antibiotics.

Adult↗
PubMed2006

Corneal astigmatism correction with opposite clear corneal incisions or single clear corneal incision: comparative analysis.

PURPOSE: To compare the astigmatic correcting effect of paired opposite clear corneal incisions (OCCIs) on the steep axis with that of single clear corneal incisions (CCIs) in cataract patients having phacoemulsification. SETTING: Rajendra Prasad Centre for Ophthalmic Sciences, AIIMS, New Delhi, India. METHODS: This randomized prospective clinical study comprised 40 eyes of 40 patients with topographic astigmatism of more than 1.50 diopters (D). Paired 3.2 mm OCCIs were made in the steep axis in Group 1 and single CCIs in Group 2. Preoperative evaluation included uncorrected visual acuity, refraction, applanation tonometry, dilated fundoscopy, biomicroscopic examination, keratometry, and topography. The steep axis was marked before sub-Tenon's anesthesia was given and routine phacoemulsification was performed through a 3.2 mm CCI on the steep axis. An additional opposite 3-step self-sealing CCI was made in Group 1. Patients were examined 1, 4, and 12 weeks postoperatively. Visual acuity, refraction, keratometry, and topography were evaluated. RESULTS: The mean preoperative and postoperative topographic corneal astigmatism was 2.51 D +/- 0.92 (SD) and 0.91 +/- 0.54 D, respectively, in Group 1 and 2.16 +/- 0.80 D and 1.57 +/- 0.70 D, respectively, in Group 2. Mean astigmatic correction was 1.66 +/- 0.5 D and 0.85 +/- 0.75 D in Group 1 and Group 2, respectively. Mean surgically induced astigmatism, measured by a vector-corrected method, was 1.66 +/- 0.50 D and 0.85 +/- 0.75 D in Group 1 and Group 2, respectively (P = .00). The coupling ratio was -0.96 in Group 1 and -0.87 in Group 2. The spherical equivalent was +0.23 +/- 0.41 D in Group 1 and +0.11 +/- 0.17 D in Group 2 at 12 weeks. Uncorrected visual acuity was better in Group 1 than in Group 2 (P = .032). There was no difference in best corrected visual acuity between the groups. There were no incision-related complications. CONCLUSION: Paired OCCIs were predictable and effective in providing an enhanced effect for correcting preexisting corneal astigmatism in cataract surgery.

Astigmatism↗
PubMed2006

Aureobasidium pullulans keratitis.

BACKGROUND: Corneal ulcer caused by Aureobasidium pullulans is considered to be a rare entity. So far very few reports have appeared in the world literature and the authors' hospital is the first to report from Nepal. Although A. pullulans is regarded as a contaminant, it should be considered as a pathogen if isolated from corneal ulcer specimen with clinical signs of infection and with growth of the organism on two or more culture media or growth in one medium with consistent direct microscopy findings or growth of the same organism on repeated corneal scrapings. In the present study, a series of proven cases of A. pullulans corneal ulcers at a tertiary eye care centre of Eastern Nepal is reported. METHODS: A retrospective analysis of stored data of microbiological and clinical cases of corneal ulcer was carried out. All consecutive patients (447 patients) with presumed microbial keratitis from 1 August 1998 to 31 July 2001 were evaluated with regards to clinical details, microbiological examination and management. RESULTS: Of 200 fungal organisms isolated from the cultures, 25 were identified as A. pullulans. These ulcers showed negligible improvement to topical natamycin and required either topical fluconazole or topical itraconazole in all along with systemic intravenous fluconazole in eight patients. Of 25 eyes, 22 responded well to antifungal therapy and 2 required therapeutic penetrating keratoplasty. One patient was lost to follow up for 3 months and revealed phthisis bulbi on subsequent examination. CONCLUSIONS: Aureobasidium pullulans corneal infection should be considered as a cause of keratomycosis.

Ascomycota↗
PubMed2006

Bilateral dissociated vertical deviation in a case of congenital hereditary endothelial dystrophy.

Dissociated vertical deviation (DVD) is an intermittent anomaly of the non-fixing eye. Although association of DVD with sensory visual deprivation owing to congenital or acquired opacities of the ocular media has been reported, its association with congenital hereditary endothelial dystrophy (CHED) has not been reported hitherto. We report a case having a bilateral asymmetric DVD, in a know case of bilateral CHED.

Child, Preschool↗
PubMed2005

Traumatic lenticele.

A 55-year-old woman presented with sudden diminution of vision in her left eye following trauma with her own finger. Examination revealed a firm subconjunctival swelling superiorly with aphakia and hypotony. Lens spike was absent on B-scan. Ultrasonic biomicroscopy showed thickened conjunctiva, a subconjunctival mass lesion with an underlying uveoscleral discontinuity. A surgical repair was performed with successful restoration of globe integrity. This case demonstrates that ultrasonic biomicroscopy may reveal the site and the extent of occult scleral rupture and help in precise surgical planning.

Cataract↗
PubMed2003

Painting technique for staining the anterior lens capsule.

We describe a technique of capsule staining called capsule painting. Using a Khokhar capsule painting cannula, the dye is spread directly over the anterior capsule but to no other part of the anterior chamber. There is minimal turbulence in the anterior chamber as there is no need to replace the injected viscoelastic material. The use of minimal dye and viscoelastic material reduces the cost of surgery.

Capsulorhexis↗
PubMed2003

Phacoemulsification in a case of microspherophakia.

Phacoemulsification with implantation of an acrylic foldable intraocular lens in a 14-year-old girl with microspherophakia is described. The associated lenticular myopia was disabling in terms of quality of life. With the help of nylon iris hooks, the procedure was uneventful and the outcome successful

Acrylic Resins↗
PubMed2003

Role of 0.02% polyhexamethylene biguanide and 1% povidone iodine in experimental Aspergillus keratitis.

PURPOSE: To determine the efficacy of 0.02% polyhexamethylene biguanide and 1% povidone iodine in experimental keratitis. METHODS: Aspergillus fumigatus keratitis was induced by corneal intrastromal injection of spores in 24 healthy rabbits that were randomly divided into four groups of six rabbits each. Drugs used were 5% natamycin (standard antifungal), 0.02% polyhexamethylene biguanide (PHMB) (test drug), 1% povidone iodine (test drug), and 0.5% hydroxypropylmethyl cellulose (HPMC) (control). RESULTS: The average healing times of the ulcer were 21.5 +/- 3.08 days with 5% natamycin, 27.8 +/- 2.28 days with 0.02% PHMB, 36.4 +/- 2.57 days with 1% povidone iodine, and 38.2 +/- 4.74 days with 0.5% HPMC. While no corneal perforations occurred with natamycin treatment, one perforation was noted with PHMB, three perforations were noted with povidone iodine, and five perforations were noted with controls. CONCLUSION: Polyhexamethylene biguanide (0.02%) is a moderately effective drug for experimental Aspergillus keratitis, but 1% povidone iodine is not effective.

Animals↗