Biomedical subjects

Anna J Park

Publications and source records attributed to Anna J Park.

3 recordsLinked to original sources

PubMed2003

Bilateral keratoconus after LASIK in a keratoconus patient.

PURPOSE: To describe a case of bilateral keratoconus occurring after LASIK in a keratoconus suspect. METHOD: Case report. RESULTS: A 33-year-old male presented to our institution for evaluation of poor vision 4 years after undergoing bilateral LASIK for the treatment of compound myopic astigmatism. Corneal topography examination showed marked bilateral inferior steepening, and a slitlamp examination revealed classic signs of keratoconus. A review of his preoperative corneal topography showed bilateral inferior steepening, but no other clinical signs of keratoconus were noted at the time of the operation. CONCLUSIONS: A finding of inferior steepening on corneal topography examination should be regarded as a contraindication to the LASIK procedure.

Adult↗

PubMed2002

Porphyria cutanea tarda presenting as cicatricial conjunctivitis.

PURPOSE: To report a case of porphyria cutanea tarda presenting as cicatricial conjunctivitis. DESIGN: Observational study. METHODS: A 31-year-old man presented with bilateral inferior symblepharon, superior tarsal conjunctival scarring and concretions, and recurrent conjunctival and episcleral injection. RESULTS: Four years after initial presentation, the patient developed hepatitis C, and 2 years later blisters on his scalp and hands. Direct immunofluorescence studies of biopsies taken from the palpebral conjunctiva of the right lower lid were negative for cicatricial pemphigoid. A twenty-four hour urine specimen analysis revealed elevated levels of uroporphyrins and polycarboxylated porphyrins, confirming the diagnosis of porphyria cutanea tarda. The patient was treated with repeated phlebotomies and oral hydroxychloroquine, which resulted in a significant decrease in the skin lesions, conjunctival injection, and concretions under the upper lids. CONCLUSIONS: Cicatricial conjunctivitis may be a manifestation of porphyria cutanea tarda.

Administration, Oral↗

PubMed2002

Central discoid corneal dystrophy.

PURPOSE: To present a small kindred with a unique dominantly inherited corneal stromal dystrophy. METHODS: A 31-year-old man was noted to have bilateral, symmetric, central discoid corneal stromal opacification. We performed bilateral penetrating keratoplasties for decreased visual acuity, glare, and photophobia. RESULTS: Light microscopy revealed multiple extracellular vacuoles, concentrated in the anterior one-half of the central corneal stroma. Material within the vacuoles demonstrated intense reactivity with alcian blue and colloidal iron stains, consistent with glycosaminoglycan deposition. Transmission electron microscopy demonstrated nonmembrane-bound vacuoles in the stroma that contained a faintly osmiophilic matrix and black circular profiles. Immunohistochemical analysis of the vacuolar deposits revealed that chondroitin sulfate was the primary glycosaminoglycan present. A clinical and serologic evaluation revealed no evidence of a systemic storage disorder. Genetic analysis did not reveal a mutation in the coding region of the CHST6 gene. CONCLUSIONS: Given these unique clinical and histopathologic findings as well as nearly identical clinical findings in the patient's father and one of four brothers, the authors believe that this represents a previously unreported, dominantly inherited corneal stromal dystrophy.

Adult↗