Biomedical subjects

Anna Malm

Publications and source records attributed to Anna Malm.

9 recordsLinked to original sources

PubMed2005

Slime production and cell surface hydrophobicity of nasopharyngeal and skin staphylococci isolated from healthy people.

The collection of 314 staphylococcal strains including Staphylococcus aureus and coagulase-negative staphylococci (CNS) was isolated from skin or nasopharynx of healthy people. It was found that the majority of staphylococci possessed the ability to produce slime intensively or moderately, irrespective of ecological niche-nose, throat or skin. Most of them showed the hydrophilic cell surface. However, among S. aureus skin isolates or CNS throat isolates predominated strains with hydrophobic cell surface. There was a slight correlation between slime production and the nature of cell surface among CNS isolates but not among S. aureus strains. It was found that most of slime-producing CNS strains showed hydrophilic cell surface, while slime-negative isolates usually possessed hydrophobic cell surface. Our data suggest that slime production but not cell surface hydrophobicity can be regarded as an essential colonization factor responsible for staphylococci adherence to skin or mucous membranes of upper respiratory tract. These data also suggest that slime production seems to be a general feature of staphylococci isolated from various niches of healthy people.

Adult↗

PubMed2004

[Hydrophobic properties of gram-negative rods colonizing upper respiratory tract of healthy people].

The cell surface hydrophobicity is one of the non specific factors of adhesion influencing the ability of microorganisms to colonize nasopharynx. The aim of this paper was to evaluate via salt aggregation test (SAT) the cell surface hydrophobicity of 150 strains of gram-negative rods isolated from the throat or/and nasal specimens of healthy people. It has been found that among the nonfermenting rods hydrophobic strains were predominant. In contrast, the isolates of Enterobacteriaceae family were characterized by the distinctive features of the cell surface within particular genera or even species. The obtained results show that, despite differences in cell surface hydrophobicity, numerous species of gram-negative rods have the ability to colonize the mucous membrane of upper respiratory tract. This suggests that the cell surface hydrophobicity is rather a feature of species or genus, but it is not related to the ecological niche of microorganisms in human body.

Bacterial Adhesion↗

PubMed2004

Synthesis and potential antimycotic activity of 4-substituted-3-(thiophene-2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones.

In the reaction of hydrazide of thiophene-2-acetic acid (1) with isothiocyanates, the respective thiosemicarbazides 2a-g were obtained. Further cyclization with 2% NaOH led to formation of 4-substituted-3-(thiophene- 2-yl-methyl)-Delta2-1,2,4-triazoline-5-thiones (3a-g). These compounds showed promising antimycotic activity.

Antifungal Agents↗

PubMed2003

[Microflora colonizing pleural drains after thoracic surgery].

The aim of this paper was to analyse aerobic and anaerobic bacterial flora colonizing pleural drains in 32 patients with lung tumor undergoing pulmonary resection and receiving antimicrobial prophylaxis. Fluid from pleural drains was taken up on the day of operation and on the 3-rd or 4-th day after the operation. Significant number of aerobic bacteria, mainly methicillin-resistant coagulase-negative staphylococci and multidrug resistant Gram-negative rods, were isolated from 30 (46.9%) specimens. Lower number of anaerobic bacteria were found in 24 (37.5%) specimens. Colonization of the pleural drains does not mean infection, (in only one patient isolated Pseudomonas aeruginosa could be the etiologic agent of infection) however knowledge about bacterial species found in drain fluid in a local population and drug susceptibility of isolated strains allows to propose effective antimicrobial prophylaxis.

Adult↗

PubMed2003

[Phenotypic characteristics of coagulase-negative Staphylococci colonizing pleural drains in patients with lung cancer after thoracic surgery].

Coagulase-negative staphylococci (CNS) represent an important group of etiologic agents of infections associated with plastic biomaterials, e.g. drains. In the present paper 33 strains of CNS were characterized. All of them were isolated from fluid of pleural drains in patients with lung cancer after pulmonary resection under conditions of antimicrobial prophylaxis. The most frequently isolated species were Staphylococcus epidermidis and S. warneri. The majority of CNS strains showed ability to produce slime and possessed hydrophobic properties of cell surface. Strains of CNS resistant to penicillin and oxacillin, but sensitive to amoxicillin/clavulanate were isolated most frequently. Only two methicillin-resistant strains, belonging to S. haemolyticus, were found. The obtained data indicate that CNS strains colonizing pleural drains had potential ability to adhere to smooth surfaces. Most of isolated strains were susceptible to antibiotics and chemotherapeutics routinely used in staphylococcal infections.

Anti-Infective Agents↗

PubMed2003

Preoperative chemotherapy as a predisposing factor for colonization of upper respiratory tract with Candida spp. in patients with non-small cell lung cancer.

In the present study 48 patients with non-small cell lung cancer (NSCLC) were included--20 patients from control group and 28 patients after at least one course of preoperative chemotherapy. The analysis of nasopharyngeal microflora in these patients suggests that preoperative chemotherapy can be regarded as a predisposing factor for colonization of mucous membrane of throat with yeast-like fungi--Candida spp.

Adult↗

PubMedDate not supplied

Synthesis and biological action of 1-substituted-3-R-4-phenyl-delta 2-1,2,4-triazoline-5-thione.

Using common substitution reactions, several 4-phenyl-delta2-1,2,4-triazoline-5-thione [I] and 4-phenyl-3-(pyridin-3-yl)-delta2-1,2,4-triazoline-5-thione [II] derivatives of 1-substituted-3-R-4-phenyl-delta2-1,2,4-triazoline-5-thione were obtained. These new compounds were screened for their antibacterial activities.

Microbial Sensitivity Tests↗

PubMedDate not supplied

Synthesis and biological action of 1-aminomethyl derivatives of 3-R-4-phenyl-delta2-1,2,4-triazoline-5-thione.

4-Phenyl-1,2,4-triazoline-5-thione [I] and 4-phenyl-3-(pyridin-3-yl)-1,2,4-triazoline-5-thione [II] were subjected to the reaction of aminomethylation with piperazine derivatives. Compounds [III] and [IX] were screened for their antibacterial activities.

Amines↗

PubMedDate not supplied

Lipophilicity, antifungal and antioxidant properties of persilben.

The lipophilicity of persilben, an important parameter influencing the penetration of the compound through biological membranes, was determined experimentally by dynamic method and was theoretically calculated according to the fragmentation methods introduced by Crippen, Broto and Viswanadhan. The higher value of partition coefficient (log P = 3.89) obtained for persilben than that for resveratrol points to potentially higher ease of penetration of persilben into cells of living organism. Antimicrobial and antioxidant activities of persilben were tested. The obtained data suggest that this compound possesses some antioxidant activity. Persilben appears to have also some inhibitory effect against some species of dermatophytes from Tnichophyton genus but only at high concentrations.

Anti-Bacterial Agents↗