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Anne Grethe Jurik

Publications and source records attributed to Anne Grethe Jurik.

6 recordsLinked to original sources
PubMed2005

Whole body and forearm substrate metabolism in hyperthyroidism: evidence of increased basal muscle protein breakdown.

Thyroid hormones have significant metabolic effects, and muscle wasting and weakness are prominent clinical features of chronic hyperthyroidism. To assess the underlying mechanisms, we examined seven hyperthyroid women with Graves' disease before (Ht) and after (Eut) medical treatment and seven control subjects (Ctr). All subjects underwent a 3-h study in the postabsorptive state. After regional catheterization, protein dynamics of the whole body and of the forearm muscles were measured by amino acid tracer dilution technique using [15N]phenylalanine and [2H4]tyrosine. Before treatment, triiodothyronine was elevated (6.6 nmol/l) and whole body protein breakdown was increased 40%. The net forearm release of phenylalanine was increased in hyperthyroidism (microg.100 ml(-1).min(-1)): -7.0 +/- 1.2 Ht vs. -3.8 +/- 0.8 Eut (P = 0.04), -4.2 +/- 0.3 Ctr (P = 0.048). Muscle protein breakdown, assessed by phenylalanine rate of appearance, was increased (microg.100 ml(-1).min(-1)): 15.5 +/- 2.0 Ht vs. 9.6 +/- 1.4 Eut (P = 0.03), 9.9 +/- 0.6 Ctr (P = 0.02). Muscle protein synthesis rate did not differ significantly. Muscle mass and muscle function were decreased 10-20% before treatment. All abnormalities were normalized after therapy. In conclusion, our results show that hyperthyroidism is associated with increased muscle amino acid release resulting from increased muscle protein breakdown. These abnormalities can explain the clinical manifestations of sarcopenia and myopathy.

Adult↗
PubMed2004

Chronic recurrent multifocal osteomyelitis.

Chronic recurrent multifocal osteomyelitis (CRMO) is a clinical entity distinct from bacterial osteomyelitis. It occurs mainly in children and adolescents and is characterized by a prolonged, fluctuating course with recurrent episodes of pain occurring over several years. CRMO is often multifocal and most often seen in tubular bones, the clavicle, and less frequently the spine and pelvic bones; other locations are rare. The radiographic appearance suggests subacute or chronic osteomyelitis. Histopathological and laboratory findings are nonspecific and bacterial culture is usually negative. CRMO is often diagnosed by exclusion of the two main differential diagnoses--bacterial infections and tumor--by assessing for a characteristic course and the findings by conventional radiography, if necessary supplemented by scintigraphy and/or magnetic resonance imaging (MRI). The MRI appearance of CRMO lesions in tubular bones and the spine is often rather characteristic and support the diagnosis. It is important to diagnose CRMO to avoid unnecessary diagnostic procedures and initiate an appropriate therapy.

Adolescent↗
PubMed2003

Optimisation of scoliosis examinations in children.

OBJECTIVE: To present results of optimising scoliosis examination by changing from a conventional film/grid (F/G) to air-gap technique using computed radiography (CR), and to evaluate different methods for estimating effective radiation doses. MATERIALS AND METHODS: Forty-nine children and adolescents were examined with an F/G technique, and 21 with air-gap and CR techniques. Entrance surface doses (ESD) were determined with lithium fluoride thermoluminescence dosimeters. For all patients, the effective radiation doses were determined using a hermaphrodite PCXMC computer program. For all F/G radiographs, the effective doses were also determined according to the NRPB-R279 report, and for 22 children (>9 years and/or >40 kg) also with the ODS-60 program, which allows separate gender calculations. Accumulated doses for 37 children examined more than once with F/G examinations were assessed. RESULTS: For F/G techniques, the ESDs for both frontal and lateral views varied with age and were significantly correlated to the patients' thickness. The calculated effective doses using the PCXMC program and the NRPB-R279 did not differ significantly for all frontal and lateral radiographs, respectively, but ODS-60 gave significantly higher values in female subjects. With air-gap and CR techniques, the mean effective doses were reduced by a factor over 10. The mean accumulated effective dose for 37 children with a mean of seven F/G examinations was 6.1 mSv, implying a risk of death of about 1:2,000 for boys and at least 1:1,000 for girls. CONCLUSIONS: Paediatric scoliosis radiography should be considered a specialised procedure, which has to be optimised using a non-grid technique.

Child↗
PubMed2003

[Surgical treatment of giant cell tumor of bone].

INTRODUCTION: This study analyses a 5-year follow-up after treatment of giant cell tumour of bone during a 31-year period. MATERIAL AND METHODS: Sixty patients with giant cell tumours of bone had been treated at the Centre for Musculoskeletal Tumours at Aarhus University Hospital. All patients were followed at regular intervals for 5-35 years, median = 11 years. RESULTS: There were 54 benign giant cell tumours of bone, whereas six were classified as malignant. The most common location was around the knee. There were nine cases of recurrence. The 5-year recurrence-free survival was 77%. The lowest frequency of recurrence appeared after resection (6%) and the highest after bone-transplantation (22%). DISCUSSION: The classical microscopic and macroscopic criteria for malignancy are not applicable for this rare tumour. All giant cell tumours of bone should be considered as potentially malignant, and therefore patients should be referred to a Centre for Musculoskeletal Tumours.

Adolescent↗
PubMed2002

Effective radiation dose from semicoronal CT of the sacroiliac joints in comparison with axial CT and conventional radiography.

The aim of this study was to evaluate the radiation dose given by semicoronal CT of the sacroiliac joints (SIJs) in comparison with axial CT and conventional radiography. The total effective radiation doses given by serial contiguous semicoronal and axial CT, using 5-mm slices, 120 kV and 330 mAs, were determined by measurement of organ doses using an anthropomorphic Rando Alderson phantom paced with thermoluminescence dosimeters. The doses given by conventional antero-posterior (AP) and oblique projections of the SIJs were determined similarly. In a female the total effective dose by semicoronal CT was found to be more than six times lower than by axial CT and 2.5 times lower than the dose use to obtain a conventional AP radiograph, the values being 102, 678, and 255 micro Sv, respectively. The effective dose by semicoronal CT was only a little higher than the dose given to obtain two oblique radiographs. In a male with lead protection of the gonads the dose by semicoronal CT was four times lower than by axial CT, but higher than by conventional radiography. In conclusion, the effective dose by semicoronal CT of the SIJs is lower than by axial CT, and in females a semicoronal CT implies a lower effective radiation dose that used to obtain an AP radiograph.

Female↗