Biomedical subjects

Anne M Buison

Publications and source records attributed to Anne M Buison.

4 recordsLinked to original sources

PubMed2005

Bone area and bone mineral content deficits in children with sickle cell disease.

OBJECTIVE: Children with sickle cell disease (SCD) experience poor growth, altered body composition, and delayed maturation. Deficits in bone mineral content (BMC) and bone area (BA) have not been well characterized. The objectives of this study were to assess whole-body BMC (WBBMC) and WBBA in children with SCD, type SS (SCD-SS), compared with healthy control subjects, adjusted for growth and body composition, and to determine the relationships of WBBMC and WBBA to bone age and hematologic parameters in children with SCD-SS. METHODS: WBBMC, WBBA, and lean mass were measured by dual-energy x-ray absorptiometry in children who were aged 4 to 19 years. Growth, sexual development, and bone age were assessed. Gender-specific z scores for WBBMC relative to age and height were generated from control data. RESULTS: Ninety children with SCD-SS and 198 healthy control subjects were evaluated. SCD-SS was associated with poor growth. WBBMC was significantly decreased in SCD-SS compared with control subjects, adjusted for age, height, pubertal status, and lean mass. WBBMC relative to age and WBBMC relative to height z scores were -0.95 +/- 0.99 and -0.54 +/- 0.97, respectively, and were associated with hemoglobin and hematocrit levels and history of delayed bone age. CONCLUSIONS: Children with SCD-SS have significant deficits in WBBMC that persist despite adjustment for poor growth and decreased lean mass. These children may be at increased risk for fragility fractures and suboptimal peak bone mass.

Absorptiometry, Photon↗

PubMed2004

Low vitamin D status in children with sickle cell disease.

OBJECTIVES: To examine vitamin D status in children with sickle cell disease (SCD)-SS and its relation to season and dietary intake. STUDY DESIGN: Growth, dietary intake, 25-hydroxyvitamin D (25-OHD), and parathyroid hormone levels were measured. Children with low and normal vitamin D status were compared. Low vitamin D status was defined as a serum concentration of 25-OHD <27.5 nmol/L. Serum 25-OHD and parathyroid hormone levels were compared among children with SCD-SS and healthy children. RESULTS: Children with SCD-SS (n=65), 5 to 18 years of age, were evaluated. Mean (+/-SD) serum 25-OHD concentration was 25.5 +/- 12.8 nmol/L; 65% of subjects had low vitamin D status. Low vitamin D prevalence was highest during spring (100%). Children with SCD-SS were at higher risk for low vitamin D status than healthy children. Vitamin D intake was lower in subjects with SCD-SS and low vitamin D than those with normal serum vitamin D status (P <.05). CONCLUSIONS: Low serum vitamin D status was highly prevalent in black children with SCD-SS. Vitamin D status was associated with season and dietary intake.

Adolescent↗

PubMedDate not supplied

Methodological agreement between two-compartment body-composition methods in children.

Increases in childhood obesity have emphasized the importance of accurate and accessible body composition assessment, especially in monitoring prevention and treatment efforts. Previous pediatric studies, comparing measures from air-displacement plethysmography (ADP) to dual-energy X-ray absorptiometry (DXA) and anthropometry (ANTH, skinfold measures), were performed in small numbers of children or in children across large age and body-size ranges. The objectives of this study were: 1) to compare body fat percentage (%BF), fat mass (FM), and fat-free mass (FFM) from ADP with DXA and ANTH, to determine the agreement between techniques; 2) to identify factors that influence agreement or lack of agreement; and 3) to determine if the agreement is constant over a range of body fatness. Healthy children (n = 125), 7-10 years old, participating in a longitudinal pediatric bone health study, were evaluated. Body composition was assessed by ADP, DXA, and ANTH to determine %BF, FM, and FFM. ADP underestimated %BF compared to DXA and ANTH by 5.0% and 1.4%, respectively. Agreement between techniques was influenced by body fatness, height, age, and gender (all P < 0.05). Relatively good agreement was observed between ADP and both DXA and ANTH for FM and FFM. In conclusion, the underestimation of %BF by ADP compared to DXA may be of a magnitude that is clinically significant, especially when using %BF in children to confirm a diagnosis of obesity. Further development of body-composition techniques for young children need to account for variability in age, gender, and level of fatness.

Absorptiometry, Photon↗

PubMedDate not supplied

Statistical validation of air-displacement plethysmography for body composition assessment in children.

BACKGROUND: Body composition assessment of children has been hindered by the absence of a safe, quick, and easily tolerated gold standard technique. Existing validation studies of air-displacement plethysmography (ADP) have been based on small, narrowly defined samples, using simple linear regression or Bland-Altman analyses. AIM: Correlations within a multitrait-multimethod matrix (MTMM) and factor analytic methodologies were used to evaluate ADP as a valid and reliable body composition technique for children. SUBJECTS AND METHODS: Fat mass (FM), fat-free mass (FFM) and per cent body fat (%BF) were measured in 139 children, 7-10 years old, by ADP, dual energy X-ray absorptiometry (DXA) and anthropometry (ANTH). MTMM and factor analysis were used to compare assessment techniques. RESULTS: Reliability estimates were lower for ADP than for either ANTH or DXA. Convergent and discriminant correlations between ADP and ANTH or DXA were high for identical as well as non-identical measures. Two body composition factors (Fatness, Leanness) and two technique-related factors (Bod Pod, Anthropometry) were identified. CONCLUSION: ADP offers a valid and reliable means of assessing body composition in children but does not perform as well as ANTH or DXA. MTMM and factor analytic methodologies offer an effective alternative to assessing body composition.

Absorptiometry, Photon↗