PubMed Health⌕ Search

Biomedical subjects

Anthony Lee

Publications and source records attributed to Anthony Lee.

8 recordsLinked to original sources
PubMed2006

On intersubjective engagement in autism: a controlled study of nonverbal aspects of conversation.

Does autism involve a deficit in intersubjective engagement with other persons? We studied nonverbal communication in children and adolescents with and without autism (n = 12 per group), group-matched for chronological age and verbal mental age, during 3 min of a videotaped interview. In keeping with previous studies, there were only subtle but potentially revealing group differences on behavioral ratings. Participants with autism made fewer head-shakes/nods (but not smiles) when the interviewer was talking, and the interviewer made fewer head-shakes/nods when participants were talking. Yet there were marked group differences on reliable 'subjective' ratings of (a) affective engagement and (b) the smoothness of reciprocal interaction. We interpret the findings in terms of a group difference in identification between conversational partners.

Adolescent↗
PubMed2006

Foundations for self-awareness: An exploration through autism.

Developmental psychopathology holds promise for elucidating the structure of self-awareness. Here we studied social emotions in matched groups of children and adolescents with and without autism. Our aims were to determine whether there are potentially dissociable aspects of self-awareness, and to reconsider how the qualities of young children's engagement with other persons influences the development of their sense of self. Parent interviews yielded evidence that children with autism are limited in social-relational and emotional domains of self-awareness; for example, few were reported to show guilt, embarrassment, or shame. Yet according to parent report, most were affected by the moods of others, showed some degree of pity and concern, and manifested jealousy. When presented with videotaped scenes, participants with autism were similar to those without autism in identifying pride, guilt, and shame, and they were able to describe their own experiences of pride and, more rarely, guilt. In situations designed to elicit emotions, participants with autism were rated as showing pride, but they manifested lesser degrees and atypical qualities of guilt and coyness. Relatively few showed personal forms of self-consciousness when asked to pose for a photograph. We argue that in order for children to achieve depth in self-awareness, and to relate to themselves as occupying a distinctive stance within a framework of mutual self-other relatedness, they need to identify with the attitudes of other people. We interpret the present studies in terms of dissociations among three forms of social emotion: "person-centered" qualities of relational self-awareness that require identification and are specifically limited among children with autism, more diffuse modes of relational self-consciousness, and a third group of social emotions, epitomized by jealousy, situated in a separate developmental line. We propose a rebalancing of emotion theory that gives greater prominence to children's developing forms of interpersonal and intra-psychic relatedness.

Affect↗
PubMed2005

The effect of heparin on structural and functional properties of low density lipoproteins.

Heparin binding to human low density lipoproteins (LDL) and the effect of heparin on the ability of LDL to bind to the LDL receptor has been investigated. Emphasis has been made on the physiological conditions of temperature, pH and the ionic strength. Intrinsic fluorescence spectroscopy of LDL has been applied to follow heparin binding. Fluorescence anisotropy has been measured to describe the changes in apoB and dansyl-heparin dynamics upon binding. Eu3+-labeled LDL binding to the intact LDL receptor has been monitored by time-resolved fluorescence spectroscopy technique. We have found that heparin binds to LDL under the physiological conditions, probably by Van der Waals interactions and hydrogen bonding. Temperature seems to be the most important factor influencing the interaction. Furthermore, the presence of heparin inhibits LDL binding to the intact LDL receptor that might have consequences on the cholesterol metabolism in vivo.

Apolipoproteins B↗
PubMed2005

A single amino acid residue can determine the sensitivity of SERCAs to artemisinins.

Artemisinins are the most important class of antimalarial drugs. They specifically inhibit PfATP6, a SERCA-type ATPase of Plasmodium falciparum. Here we show that a single amino acid in transmembrane segment 3 of SERCAs can determine susceptibility to artemisinin. An L263E replacement of a malarial by a mammalian residue abolishes inhibition by artemisinins. Introducing residues found in other Plasmodium spp. also modulates artemisinin sensitivity, suggesting that artemisinins interact with the thapsigargin-binding cleft of susceptible SERCAs.

Amino Acid Sequence↗
PubMed2005

Personal relatedness and attachment in infants of mothers with borderline personality disorder.

The principal aim of this study was to assess personal relatedness and attachment patterns in 12-month-old infants of mothers with borderline personality disorder (BPD). We also evaluated maternal intrusive insensitivity toward the infants in semistructured play. We videotaped 10 mother-infant dyads with borderline mothers and 22 dyads where the mothers were free from psychopathology, in three different settings: a modification of Winnicott's Set Situation in which infants faced an initially unresponsive ("still-face") stranger, who subsequently tried to engage the infant in a game of give and take; the Strange Situation of Ainsworth and Wittig; and a situation in which mothers were requested to teach their infants to play with miniature figures and a toy train. In relation to a set of a priori predictions, the results revealed significant group differences as follows: (a) compared with control infants, toward the stranger the infants of mothers with BPD showed lower levels of "availability for positive engagement," lower ratings of "behavior organization and mood state," and a lower proportion of interpersonally directed looks that were positive; (b) in the Strange Situation, a higher proportion (8 out of 10) of infants of borderline mothers were categorized as Disorganized; and (c) in play, mothers with BPD were rated as more "intrusively insensitive" toward their infants. The results are discussed in relation to hypotheses concerning the interpersonal relations of women with BPD, and possible implications for their infants' development.

Adult↗
PubMed2005

Symbolic play in congenitally blind children.

There is controversy over the existence and nature of blind children's limitations in symbolic play. In this study we tested 13 5- to 9-year-old congenitally blind children for the ability to symbolize when an adult provided scaffolding for their play. The blind children were selected on the basis that they did not have the syndrome of autism, and they comprised two groups matched for age (MA) and verbal ability on the Wechsler Intelligence Scale for Children who contrasted in their ability to engage in social relations. We also tested a group of sighted children who were MA matched with the more socially able blind children. On the basis of an hypothesis about the social-developmental sources of symbolic play deficits in congenitally blind children, we predicted differences between the socially able and socially impaired groups of blind children in the following respects: the attribution of symbolic meanings to play materials, the ascription of individual roles to play figures, and the anchorage of play in the scenario as presented by the adult. The results accorded with these predictions. Whereas the more socially able blind children showed symbolic play that was very similar to that of sighted children, the MA- and IQ-matched socially impaired blind children were limited in the three aspects of their play. On the other hand, even the socially impaired children showed instances of symbolizing. The findings suggest a way to reconcile conflicting reports of symbolic play deficits in young blind children, and may be relevant for explaining the association between autism and congenital blindness.

Affect↗
PubMed2004

Maternal sensitivity and infant triadic communication.

BACKGROUND AND METHOD: The aim of this study was to examine whether a mother's sensitivity towards her one-year-old infant is related to the infant's propensity to engage in 'triadic' relations--that is, to orientate to an adult's engagement with objects and events in the world, for example in sharing experiences with an adult. In order to determine that any effects were specific to infants' behaviour in the interpersonal domain, we also tested their performance on tests of understanding means-ends relations and object permanence. RESULTS: The results were that high maternal sensitivity and low intrusiveness correlated with high levels of infant triadic interpersonal engagement with a stranger vis-a-vis performance on the non-social tasks. There was also suggestive evidence that maternal sensitivity might be related to infants' propensity to share experiences with the mother. Exploratory analyses revealed that these findings held up when the effects of maternal socio-economic status and ethnic group were taken into account; and there was some indication that the effects of maternal intrusiveness on infant profiles of performance were more marked for mothers who did not have a partner. CONCLUSION: There is a specific relation between maternal sensitivity and one-year-old infants' propensity to engage with someone else in relation to the world.

Adult↗