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Biomedical subjects

Antoine Bourrillon

Publications and source records attributed to Antoine Bourrillon.

9 recordsLinked to original sources
PubMed2006

Report of two cases of aseptic meningitis with persistence of pneumococcal cell wall components in cerebrospinal fluid after Pneumococcal meningitis.

We describe two cases of aseptic meningitis occurring some time after pneumococcal meningitis. Both cases may have resulted from an inflammatory response to persistent pneumococcal cell membrane components, as the cerebrospinal fluid samples were positive by the Binax NOW Streptococcus pneumoniae antigen test. Potential mechanisms and diagnostic impact are discussed.

Antigens, Bacterial↗
PubMed2005

Escherichia coli strains causing urinary tract infection in uncircumcised infants resemble urosepsis-like adult strains.

PURPOSE: Urinary tract infection (UTI) is the most frequent bacterial infection in infants younger than 90 days, and mainly affects uncircumcised males. In an attempt to unravel further the pathophysiology of UTI in this age group we used molecular methods to characterize Escherichia coli strains responsible for community acquired UTI in male and female infants and in adults. MATERIALS AND METHODS: A total of 79 E. coli isolates from uncircumcised male and female infants with UTI and no urinary tract abnormalities and 41 E. coli pyelonephritis isolates from nonhost compromised adults with bacteremia were characterized in terms of phylogenic relatedness and virulence factors. RESULTS: Males were infected by strains with a genetic background and virulence factors different from those affecting females but similar to those of adult pyelonephritis strains. CONCLUSIONS: Our molecular approach indicates that uncircumcised male infants are at higher risk for infection with highly virulent uropathogenic E. coli strains than are females. Preputial colonization may have a key role in the selection of such strains.

Adult↗
PubMed2004

[Meningococcal disease due to Neisseria meningitidis serogroup W135 in children. Clinical aspects and outcome].

OBJECTIVE: Meningococcal disease due to Neisseria meningitidis of serogroup W135 (N. meningitidis W135) is increasing in France. Clinical and outcome data concerning these infections in children are scarce. PATIENTS: We report 5 cases of children hospitalised in our unit between June 2000 and December 2002 for N. meningitidis W135 infection. CASE REPORTS: Among these 5 children aged 19 months to 11 years, 3 presented with a primary meningitis and 4 with primary or secondary extra-meningeal involvement, articular in 3 cases, pericardial in 2 cases and ocular in one case. The outcome was favourable without after effects in 4 cases, marked by a resistant prolonged post-meningococcal inflammatory syndrome. COMMENTS: Extra-meningeal septic and/or non septic complications are frequent and a prolonged post meningococcal inflammatory syndrome is reported. In N. meningitidis W135 infections a careful clinical evaluation of potential extra-meningeal complications and a long term follow up of children are needed.

Aftercare↗
PubMed2004

[Chemoprophylaxis and vaccine for prevention of bacterial meningitis in children].

Given the devastating nature of Neisseria meningitidis disease and emergence of resistant strains prevention through chemoprophylaxis and meningococcal vaccine remains the best approach to control this serious infection. Chemoprophylaxis may limited strictly to the contact subjects. Polysaccharide meningococcal serogroups A, C, Y and W135 should be given less than 10 days to patients with prolonged contact with the index case. Meningococcal C conjugate vaccine constitutes an additional advantage in the prevention of meningococcal meningitis in children < 2 years. High Haemophilus serotype B coverage level led to near-disappearance of H. influenzae serotype b meningitis but chemoprophylaxis remains indicated.

Adolescent↗
PubMed2004

Clinical features and outcome of pediatric Neisseria meningitidis serogroup W135 infection: a report of 5 cases.

We describe 5 pediatric cases of Neisseria meningitidis serogroup W135 infection. Infectious and/or reactive extrameningeal involvement was frequent. One patient had a persistent postmeningococcal inflammatory syndrome. Four of 5 isolates belonged to the clonal complex 37. The important risk of extrameningeal complications must be borne in mind when treating children with N. meningitidis W135 infection.

Arthritis, Infectious↗
PubMed2004

A pediatric cluster of Shigella dysenteriae serotype 1 diarrhea with hemolytic uremic syndrome in 2 families from France.

We report a cluster of pediatric diarrhea due to Shigella dysenteriae serotype 1 involving 11 children in France, including the index case, who had returned from Senegal. Child-to-child transmission was documented by ribotyping. Five children developed hemolytic uremic syndrome (HUS). On the basis of our findings, the choice of antimicrobial treatment for infections with S. dysenteriae serotype 1 should take into account widespread drug resistance and the risk of HUS.

Anti-Bacterial Agents↗