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Biomedical subjects

Antoni Gual

Publications and source records attributed to Antoni Gual.

14 recordsLinked to original sources
PubMed2006

[Alcoholism and immigration. Adherence of immigrant patients to group therapy].

BACKGROUND AND OBJECTIVE: Group therapy (GT) is considered a cornerstone in the treatment of alcohol dependence. Increasing numbers of foreigners are accessing alcohol treatment facilities, but efficacy of TG in those patients has not been studied. This work focuses on the influence of ethnicity and language in the compliance of GT. PATIENTS AND METHOD: 1856 consecutive patients who were referred to GT for alcohol dependence were followed until discharge or dropout. Time on treatment and final endpoint were compared according to place of birth. RESULTS: 31% of patients born in Barcelona, 39% born in Catalonia, 27% from the rest of Spain and 14.5% of foreigners (20% from Europe, 4% from America and none born in Africa (p = 0.02) completed successfully GT. The probability to stay in GT was 351, 412, 320 and 212 days (p = 0.000), respectively. DISCUSSION: Patients born abroad have lower chances to complete GT successfully, presenting with higher dropout rates and shorter treatments. The low compliance found in South American patients (who share a common language) and the better compliance found in Europeans (who are also a bit older) suggest that dropout is probably more related to social integration than to language problems.

Adult↗
PubMed2005

[Alcoholism in the general hospital: 4 years mortality and hospitalization].

BACKGROUND AND OBJECTIVE: We aimed to analyze the mortality, and emergency room and hospital admissions in a sample of alcohol dependent patients during the four years following their identification in a general hospital. PATIENTS AND METHOD: 198 inpatients from a general hospital who where identified as alcohol dependent and referred during 1998 to the liaison-psychiatry service. RESULTS: 30.8% had died, at a mean age of 57.5 (11.3). Deaths had a direct relationship to the illness responsible for the initial admission to hospital. 42.6% of patients had previous admissions, and 74% had been previously attended at emergency room departments. During the 4 years of follow up, there were new hospital admissions (54.6%), emergency room visits (72.7%) and repeated liaison-psychiatry consultations (20%). Previous admissions to hospital predicted future admissions. Acceptance of alcohol treatment did not reduce the mortality rates. Mortality correlated with age, it was increased in patients with cognitive deficits and was reduced in those with psychiatric co-morbidity. CONCLUSIONS: Late detection of alcohol dependence leads to pour outcomes both in the treatment of alcohol dependence and the concomitant somatic diseases. Early detection strategies of hazardous and harmful alcohol consumption should be implemented in hospital settings.

Alcoholism↗
PubMed2005

Prevalence and mechanisms of hyperhomocysteinemia in chronic alcoholics.

BACKGROUND: Homocysteine (Hcy) is formed as an intermediary in methionine metabolism. Impairment of Hcy remethylation or transulfuration leads to hyperhomocysteinemia, which is considered as a risk factor for atherosclerotic vascular disease and stroke in chronic alcoholics. The aim of the study was to investigate the prevalence of hyperhomocysteinemia in chronic alcoholics and the influence of alcohol consumption, vitamin deficiencies and liver damage on the plasma levels of Hcy. METHODS: 228 chronic alcoholic patients consecutively admitted for detoxication, classified according to clinical and biochemical data in normal liver (n = 117), and in mild to moderate liver disease (n = 111), and 49 healthy controls were studied. Blood levels of Hcy, vitamin B6, vitamin B12 and folate were measured. RESULTS: Plasma Hcy was significantly higher in chronic alcoholics than in controls (9.66 +/- 8.1 vs. 6.93 +/- 2.33 mumol/liter, p < 0.025). Furthermore, plasma Hcy levels were significantly higher in chronic alcoholics with liver injury (12.17 +/- 10.14 mumol/liter) than in those with normal liver and in controls (p < 0.001). The prevalence of hyperhomocysteinemia was also significantly higher in alcoholics with liver damage than in those with normal liver and in controls (29.7%, 5.1%, and 2%, respectively, p < 0.001). Serum folate values were lower in chronic alcoholics than in controls (4.7 +/- 2.6 vs. 7.6 +/- 2.4 nmol/liter, p < 0.001). The lowest values of folate were found in alcoholics with liver disease, especially in those with hyperhomocysteinemia, with a negative correlation between the two parameters. CONCLUSIONS: Moderate hyperhomocysteinemia is common in chronic alcoholics, mainly in those with liver damage, suggesting that, although folate deficiencies may have a contributory role, liver impairment, through changes in methionine metabolism, is the most important mechanism for the elevated plasma Hcy found in these patients.

5-Methyltetrahydrofolate-Homocysteine S-Methyltran↗
PubMed2005

A multicountry controlled trial of strategies to promote dissemination and implementation of brief alcohol intervention in primary health care: findings of a World Health Organization collaborative study.

OBJECTIVE: This study examines the impact of marketing strategies on the dissemination of a brief alcohol intervention program to general practitioners (GPs). The marketing strategy was tested to determine the most effective way to promote awareness about and consideration of a brief alcohol intervention program. The study also examines the impact of training and support strategies to promote the program's implementation in routine primary care. METHOD: A pragmatic trial was carried out in Australia, Belgium (Flanders), Denmark, England, New Zealand and Spain (Catalonia) in which GPs were randomly allocated into one of three marketing conditions (direct mail, telemarketing and academic detailing [personal visits]). The GPs who requested a brief intervention program and agreed to use it were stratified by previous marketing condition and randomly allocated into one of three implementation strategy groups: written guidance, outreach training and outreach training plus ongoing telephone support. RESULTS: Acceptance of the brief intervention program was more effective with use of telemarketing (65%) and academic detailing (67%) than with direct mail (32%) for promoting awareness about and consideration of a brief alcohol intervention program. The median proportion of patients screened was higher for trained GPs (6%) and supported GPs (9%) than for control GPs (1%), who received only written guidance on how to conduct brief intervention. Similarly, the median rate for giving advice to at-risk patients was higher for trained GPs (3%) and supported GPs (3%) than for control GPs (0%). CONCLUSIONS: The adoption of more direct approaches for disseminating evidence-based intervention programs to GPs is a necessary first step for changing practice behavior. However, outreach training was required to promote actual use of a new procedure in routine practice.

Adult↗
PubMed2004

[Two year follow-up of inpatients with alcohol-related diseases].

BACKGROUND AND OBJECTIVE: Our objective was to study the outcome and compliance of both medical and alcoholism treatment in alcoholics discharged from a general hospital. PATIENTS AND METHOD: This was a 2 years prospective follow up study of a cohort of 100 inpatients referred to the Alcohol Unit during the first semester of 1998. RESULTS: After 2 years, 9 patients had died and 14 had been referred to other hospitals. 15% of patients refused medical treatment from the beginning and alcoholism treatment was initially refused by 31% of alcoholics. At 2 years of follow up, compliance rates were 46% for medical treatment and 10% for alcoholism treatment. All patients under treatment for alcoholism were also good compliers of medical treatment. Survival analysis for alcoholism treatment at 2 years was 19%, with higher rates in patients with psychosocial problems and previous alcohol consultations. The probability of being alive was 89%. CONCLUSIONS: Few alcoholics are detected. Most of them display high levels of severity and poor prognosis, with high mortality rates. Compliance with follow up treatment is low. There is a clear correlation between compliance of alcoholism and medical treatment.

Adult↗
PubMed2003

[Alcoholism in the general hospital: detection and treatment].

BACKGROUND AND OBJECTIVE: Alcohol is an important factor in hospital admissions. Few publications have studied how alcoholics are handled in hospitals. PATIENTS AND METHOD: All inpatient referrals (IPC) to our Alcohol Unit (n=212) during 12 months were analyzed. RESULTS: Four departments accounted for 80% of IPC, which represented 3% of all admissions in these departments. 72% of patients showed important psycho-social problems, 46% had had previous admissions to the hospital, and 21% had been visited by the Alcohol Unit earlier. Treatment was not offered at discharge to 20% of patients because of their severe psycho-social or physical deterioration. 17% of patients refused treatment. CONCLUSIONS: Alcoholism in inpatients is underdiagnosed. Only the most severe cases are detected. Those who might benefit the most are often undiagnosed.

Adult↗
PubMed2003

Electrophysiological evidence of abnormal activation of the cerebral network of involuntary attention in alcoholism.

OBJECTIVE: Increased distractibility is a common impairment in alcoholism, but objective evidence has remained elusive. Here, a task designed to investigate with event-related brain potentials (ERPs) the neural mechanism underlying distraction was used to show abnormal involuntary orienting of attention in chronic alcoholism. METHODS: Fifteen alcoholics and 17 matched healthy controls were instructed to ignore auditory stimuli while concentrating in the discrimination of immediately following visual stimuli. The auditory sequences contained repetitive standard tones occasionally replaced by deviant tones of slightly higher frequency, or by complex novel sounds. RESULTS: Deviant tones and novel sounds distracted visual performance, i.e. increased reaction time to visual stimuli, similarly in patients and controls. Compared to controls, however, alcoholics showed ERP abnormalities, i.e. enhanced P3a amplitudes over the left frontal region, and a positive posterior deflection instead of the frontally distributed reorienting negativity (RON). CONCLUSIONS: The enhanced P3a to novelty and subsequent positive wave instead of RON in alcoholics suggests encoding into working memory of task-irrelevant auditory events and provides neurophysiological markers of impaired involuntary attention mechanisms in chronic alcoholism.

Acoustic Stimulation↗
PubMed2002

A double-blind, placebo-controlled study of naltrexone in the treatment of alcohol-dependence disorder: results from a multicenter clinical trial.

BACKGROUND: A 12-week, multicenter, double-blind, randomized, parallel-group clinical trial to compare naltrexone and placebo was carried out to determine the efficacy, safety, and tolerability of naltrexone together with a psychosocial intervention in the treatment of alcoholism. METHODS: A total of 202 alcohol-dependent patients were assigned to 12 weeks' treatment with either naltrexone or placebo. The relapse rate was evaluated by means of intention-to-treat analyses. Alcohol consumption, craving, adverse events, and changes in the biochemical markers of heavy drinking and possible toxicity were evaluated in the 192 patients who were considered to be assessable. RESULTS: The survival function for patients who were treated with naltrexone was significantly better than that of the patients who were treated with placebo (Kaplan-Meier log rank = 4, df = 1, p < 0.05). In addition, 7.9% of patients who were treated with naltrexone relapsed as compared with 18.8% of those who received placebo [chi = 5.89, df = 2, p = 0.050]. In comparing naltrexone with placebo-treated patients, the most common adverse events were abdominal pain [8.6% vs. 1%; (chi = 6.1, df = 1, p < 0.05)] and headache [7.5% vs. 1% (chi = 5.1, df = 1, p < 0.05)]. CONCLUSIONS: Naltrexone was well-tolerated, as the rate of adverse events was low, and safe, as it did not interfere with the normalization of biochemical markers of heavy drinking or alter liver function markers. Naltrexone seemed to reduce relapse rate to heavy drinking, but we found no differences in other alcohol consumption variables between naltrexone- and placebo-treated groups. Although the naltrexone group showed a tendency to consume fewer drinks per drinking day and had a longer time to first drink, differences were not statistically significant.

Adult↗
PubMedDate not supplied

Audit-3 and audit-4: effectiveness of two short forms of the alcohol use disorders identification test.

AIMS: To identify suitable short versions of the Alcohol Use Disorders Identification Test (AUDIT) and to evaluate their effectiveness as screening tests for 'risky drinking' among men and women in primary health care (PHC) settings. METHODS: A total of 255 patients attending five PHC centres in Catalonia (Spain) were interviewed by clinicians regarding health status and drinking pattern. Patients also completed the AUDIT. Clinicians' diagnosis of risky drinking was used as a gold standard to evaluate the effectiveness of three forms of AUDIT. RESULTS: AUDIT-3 and AUDIT-4 performed similarly to AUDIT-10 in detecting risky drinking and had equivalent receiver operating characteristics curves and their areas under the curve. CONCLUSIONS: Both short forms of AUDIT seem to be as effective as the full AUDIT for detecting risky drinking among men and women in PHC settings.

Adolescent↗
PubMedDate not supplied

Attitudes and managing alcohol problems in general practice: an interaction analysis based on findings from a WHO collaborative study.

AIMS: To determine if GPs' attitudes towards working with drinkers moderated the impact that training and support had on screening and brief intervention activity in routine practice. METHODS: Subjects were 340 GPs from four countries who were part of a World Health Organization randomized controlled trial to evaluate the effectiveness of training and support in increasing screening and brief alcohol intervention. GPs' self-reported attitudes towards working with drinkers were measured with the Shortened Alcohol and Alcohol Problems Perception Questionnaire. RESULTS: Whereas training and support increased GPs' screening and brief intervention rates, it did so only for practitioners who already felt secure and committed in working with drinkers. Training and support did not improve attitudes towards working with drinkers and, moreover, worsened the attitudes of those who were already insecure and uncommitted. CONCLUSIONS: To enhance the involvement of GPs in the management of alcohol problems, interventions that increase both actual experience and address practitioners' attitudes is required. Such support could take the form of on-site support agents and facilitators.

Alcoholism↗