Biomedical subjects

Antoni Krzeski

Publications and source records attributed to Antoni Krzeski.

7 recordsLinked to original sources

PubMed2006

Chronic rhinosinusitis in primary antibody immunodeficient patients.

OBJECTIVE: Some patients suffer from recurrent or chronic rhinosinusitis (CRS) because of previously unrecognized immunodeficiency disease. The purpose of the study was to evaluate the incidence of CRS in children with different types of primary humoral deficiency. STUDY DESIGN: Among 842 cases of primary immunodeficiency diseases diagnosed in the Department of Immunology of the Children's Memorial Institute in Warsaw from 1980 up to February 2006 antibody deficiencies occurred most frequently--in 50.4%. In this group the retrospective study of patients' history suggesting CRS prior to intravenous gamma-globulin substitution therapy was performed. RESULTS: CRS was observed most frequently in the group of patients with agammaglobulinemia less often in patients with dysgammaglobulinemia, and other antibody deficiencies. CONCLUSIONS: The occurrence of frequent bacterial infections, complicating common colds, should alert the physician to the possibility of immunodeficiency. Immunological testing should be an integral part of evaluation of patients with refractory CRS.

Child↗

PubMed2005

[Rhinosinusitis: classification and definitions].

Rhinosinusitis is a complex disease which is still not fully understood. It has variety of symptoms that may negatively affect quality of life. In order to provide the patients with an efficient diagnosis and effective treatment it is necessary to have the uniform classification and clear definitions of the disease. The objective of this review is to present current state of knowledge of this subject.

Algorithms↗

PubMed2005

[Medical management of chronic rhinosinusitis with macrolides].

Long-term, low-dose macrolide therapy is effective in the treatment of chronic airway inflammation. It is believed that macrolide antibiotics produce this benefit through an antiinflammatory effect that is separate from their antibiotic effect. Eosinophils are key mediators in the inflammation seen in chronic rhinosinusitis. The effect of macrolides on eosinophilic inflammation is presented. In vitro studies recently have suggested that macrolides increase eosinophil apoptosis and reduce production of eosinophil chemotactic cytokines and adhesion molecules. In vivo studies have shown a reduction in eosinophil count and activity in asthma and chronic rhinosinusitis. Further in vitro and clinical studies are required to investigate this subject. The authors present preliminary results of clinical trial.

Apoptosis↗

PubMed2004

[Frontal sinus mucocele].

Between 1995 and 2000 twenty-two patients were treated for frontal sinus mucocele in the Department of Otorhinolaryngology of Medical University of Warsaw. History and physical examination revealed several-year-old chronic rhinosinusitis (CRS) in all but one cases. Thirteen patients had been previously operated on for this reason at least once. Conservative management, mainly in periods of symptom deterioration, was applied in other patients. The only patient with negative history of CRS had undergone in the past head injury with fracture and dislocation of the anterior wall of the frontal sinus, in the past. All patients were treated surgically with use of the intranasal endoscopic approach in 15 cases, osteoplastic surgery of the frontal sinus in 5 cases and combination of both in 2 cases. Diagnostic and management protocol is discussed and compared with data presented in the literature.

Adolescent↗

PubMed2002

[Acute invasive fungal rhinosinusitis--case report].

A case report of acute invasive fungal rhinosinusitis in 28 year old woman with acute myeloid leukemia is described in this paper. The diagnosis of the fungal disease was based on clinical presentation, endoscopic evaluation of nasal cavity, computed tomography and magnetic resonance imaging of the paranasal sinuses and histopathological findings. An aggressive treatment including antifungal therapy (amphotericin B), antibiotics and the surgery of paranasal sinuses was implemented. Unfortunately the underlying disease and the fungal invasion progressed rapidly and the patient died on the forth week post-op due to cardiorespiratory failure.

Adult↗

PubMed2002

[Midfacial degloving approach in the surgical treatment of angiofibroma juvenile].

From 1996 through 2001 8 male with a diagnosis of juvenile angiofibroma were managed at the ENT Department of Medical University in Warsaw using midfacial degloving approach. Surgical technique as well as pre- and postoperative management of these patients were described. According to authors' experience midfacial degloving approach enables the broad exposition of the operating field.

Adolescent↗

PubMedDate not supplied

Cystic fibrosis in rhinologic practice.

BACKGROUND: Cystic fibrosis (CF) is the most common genetic lethal disorder that affects white populations. Chronic rhinosinusitis (CRS) with extensive nasal polyposis is one of the manifestations of CF. METHODS: The aim of this study was to determine the prevalence and extent of CRS in CF patients. RESULTS: The study indicated that the signs and symptoms of CRS were present in all patients with CF and they were more advanced than in the control group. The most severe inflammatory changes in the paranasal sinuses were detected in patients with the dF508 gene mutation type who sufferedfrom CRS for >3 years. CONCLUSIONS: Massive nasal polyposis, dilated base of the nose, mucociliary clearance impairment, and significant radiological changes (frontal and maxillary sinus hypoplasia, bony destruction, and medial bulging of the lateral nasal wall) were identified to be the characteristic signs of the CRS in CF patients.

Adolescent↗