Biomedical subjects

Antonino Vallesi

Publications and source records attributed to Antonino Vallesi.

5 recordsLinked to original sources

PubMed2006

Prefrontal involvement in source memory: an electrophysiological investigation of accounts concerning confidence and accuracy.

Although a prefrontal involvement in the memory domain is well-documented, the specific functions the frontal lobes have in episodic memory are still unclear. This study aimed to disentangle theoretical accounts of prefrontal involvement concerning objective characteristics of the retrieval (i.e., accuracy) and accounts based on subjective features (i.e., confidence). Event-related potentials (ERPs) were recorded during the test phase of a source memory task in two experiments. The task was to retrieve the word and the voice of the speaker at study (experiment 1) or the voice of the speaker together with confidence ratings about the source judgment (experiment 2). ERPs in both experiments were not modulated by the success of the voice retrieval, discarding accounts linked to the retrieval success. A right-more-than-left late prefrontal positivity was found in both experiments. Moreover, in experiment 2, waves were more positive for low- than for high-confidence responses. This pattern was observed earlier over lateral parietal scalp regions and later, and more sustained in time, over anterior prefrontal regions. The dissociable effects found within the prefrontal scalp regions, specifically along the anterior-posterior and right-left dimensions, are interpreted as markers of qualitatively different monitoring processes.

Acoustic Stimulation↗

PubMed2006

Top-down and bottom-up processes in the extrastriate cortex of cirrhotic patients: an ERP study.

OBJECTIVE: This study aims to evaluate the efficiency of top-down and bottom-up processes in the extrastriate cortex of cirrhotic patients without overt hepatic encephalopathy (HE). METHODS: Reaction times (RTs), accuracy and event-related potentials (ERPs) were recorded during the execution of a visual Simon task in 17 cirrhotic patients and 10 healthy controls. Amplitude and latency of the P1 and N1 (indexes of bottom-up processes) and of the N2pc (index of top-down processes) were measured. RESULTS: Patients were slower than controls, and patients with minimal HE (MHE) were slower than patients without MHE. The distribution analysis of RTs showed that the Simon effect decays with slower RTs in all the groups and that the shape of the distribution was different in MHE patients. No differences were found between cirrhotic patients and controls for P1 and N1 amplitude and latency. In contrast, N2pc latency was delayed in cirrhotic patients compared to controls independently of MHE. CONCLUSIONS: In the extrastriate cortex of cirrhotic patients without HE, top-down processes are altered whereas bottom-up processes are preserved. SIGNIFICANCE: The analysis of exogenous and endogenous visual components of ERPs provides a model to study the functional dissociation between top-down and bottom-up processes inside the extrastriate cortex.

Brain↗

PubMed2006

Role of the prefrontal cortex in the foreperiod effect: TMS evidence for dual mechanisms in temporal preparation.

The involvement of right dorsolateral prefrontal cortex (rDLPFC) in explicit temporal processing is well documented. Conversely, the role of this area in implicit temporal processing (e.g., foreperiod [FP] effect) is still poorly understood. The FP effect, usually observed when a range of variable FPs occur randomly and equiprobably, consists of reaction times (RTs) decreasing as the FP increases. Moreover, in such paradigms, RTs increase as a function of the preceding FP (i.e., sequential effects). Patients with lesions of the rDLPFC do not show the typical FP effect. The present study aimed to replicate these results in healthy adults using transcranial magnetic stimulation (TMS) and to further investigate whether any change of sequential effects follows a reduction of the FP effect. The results of 2 experiments (with simple and choice RT tasks, respectively) indicate that the FP effect was significantly reduced after TMS over the rDLPFC, whereas no effect was observed after stimulation of a left contralateral site and the right angular gyrus. Conversely, sequential effects were not influenced by TMS. A dual-process model of the FP phenomena is proposed to interpret the dissociation found between the 2 effects.

Adult↗

PubMed2005

Impairment of response inhibition precedes motor alteration in the early stage of liver cirrhosis: a behavioral and electrophysiological study.

Abnormality in movement initiation may partially explain psychomotor delay of cirrhotic patients, even in the absence of overt hepatic encephalopathy (HE). Therefore, the aim of this study was to determine the mechanisms of psychomotor delay observed in patients with cirrhosis in the absence of overt HE. Fourteen patients with nonalcoholic cirrhosis and 12 healthy matched control subjects underwent the lateralized readiness potential (LRP) measurement elicited by a visuospatial compatibility task (Simon task). Stimulus-triggered LRPonset reflects the time in which response is selected, while response-triggered LRP onset reflects motor execution. Cirrhotic patients showed delayed reaction times (RTs) compared to controls, particularly those with trial-making test A (TMT-A) or electroencephalogram (EEG) alterations. Stimulus-triggered LRP onset was found to be delayed in cirrhotic patients compared to controls, with a significant Group-versus-Condition interaction, showing a reduced cognitive ability to cope with interfering codes, even in patients without minimal HE (MHE). Response-triggered LRP was found to be delayed only in the patients with TMT-A or EEG alterations. In conclusion, cirrhotic patients without overt HE display a psychomotor slowing, depending first lyon response inhibition and only later accompanied by impaired motor execution.

Data Interpretation, Statistical↗

PubMed2005

Horizontal and vertical Simon effect: different underlying mechanisms?

Reaction times are usually faster when stimulus and response occur at the same location than when they do not, even if stimulus location is irrelevant to the task (Simon effect). This effect was found with both horizontal and vertical stimulus-response arrangements. The same mechanisms have been proposed to be involved in either case. Here, we compared a horizontal and a vertical Simon task by means of a RT time-course analysis of the Simon effect. Also, we analysed the lateralised readiness potential (LRP), an index of covert response-preparation processes. In the horizontal task, the Simon effect decays over time and pre-activation occurs above the motor cortex ipsilateral to the stimulus. In contrast, the Simon effect does not decay over time and no early incorrect LRP deflection is observed in the vertical task. These findings suggest that typical activation accounts can fit only the horizontal Simon effect, while a translation explanation is more suitable for the vertical Simon effect.

Adult↗