High-resolution technique for fabricating environmentally sensitive hydrogel microstructures.
Explore the source record for details and available documents.
Aluminum↗
Biomedical subjects
Antonio Baldi
Publications and source records attributed to Antonio Baldi.
Hard and soft micromachining for BioMEMS: review of techniques and examples of applications in microfluidics and drug delivery.
Recent development in microfabrication (micromachining, microelectromechanical systems, MEMS) permits the integration of hard and soft structures, and enables the design of controllable microfluidic systems, which may be applied to drug delivery. In this paper, we present a tutorial review of both classical "hard" and more recent "soft" micromachining techniques. We then provide examples where these techniques are combined to produce hydrogel-based microfluidic control systems. The most complex of these systems utilizes a very small hydrogel based on phenylboronic acid to control the flow of an insulin solution in response to changes in glucose concentration.
Drug Delivery Systems↗
Phase unwrapping by region growing.
The phase unwrapping problem consists in mingling out an integer field whose values make the original wrapped phase field continuous. Even if in principle the problem is very simple--a direct integration of the wrapped phase field suffices--in the presence of noise and/or undersampling, the solution is no longer unique and the direct integration methods usually fail to find an acceptable solution. This work presents what is to my knowledge a new unwrapping algorithm that attempts to find the solution by iteratively merging and shifting the continuous areas until a single region is built or no further moves are possible. Unlike the tile methods, the regions can have arbitrary shape and need not be ingle-connected so that, by removing the predefined size and shape constraint, the algorithm is very robust. The greater freedom of the regions' shape makes their handling more problematic, so that certain implementation aspects, critical to algorithm performance, are presented here. Some unwrapping examples are also presented and memory requirements are discussed.
Journal Article↗