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Ariane Hohoff

Publications and source records attributed to Ariane Hohoff.

20 records · Page 2Linked to original sources

Optimizing presurgical orthodontic planning by means of the transverse coordinate simulation system (TCSS).

INTRODUCTION: When planning bilateral sagittal split osteotomies according to Obwegeser and Dal Pont, inaccuracies in the presurgical prediction of the transverse osteotomy gaps may occur. This is due to limitations of plaster models when simulating surgery on an articulator. AIM: This paper demonstrates the transverse coordinate simulation system which allows presurgical prediction of the transverse discrepancy between the tooth bearing and the proximal segment after displacement, thus minimizing uncertainty for the surgeon. METHOD: Diagnostic landmarks (taken from lateral and frontal cephalograms) and clinical data describing mandibular dimensions are transferred to a two-dimensional coordinate diagram. A mandibular model is then constructed using the anterior arch form, the temporomandibular joint distance and the prospective incision pattern. RESULT: Movements in the horizontal plane and displacement of the three segments (two condylar and one mandibular arch segment) can be simulated and measured. CONCLUSION: Transverse coordinate simulation system effectively increases the accuracy of presurgical planning without additional CT data or three-dimensional jaw models. This technique may decrease the number of additional surgical manoeuvres resulting from unexpectedly wide transverse discrepancies at the osteotomy site, which often increase surgery time, necessitate additional bone grafting, and entail the risk of healing disturbances and of malrotation or dislocation of the condyle.

Cephalometry↗

Image-based extracorporeal tissue engineering of individualized bone constructs.

PURPOSE: Computer-aided technologies have been recently employed for use in extracorporeal bone tissue engineering strategies. In this pilot animal experimental study, the intention was to test whether autologous osteoblast-like cells cultured in vitro on individualized scaffolds can be used to support bone regeneration in a clinical environment. MATERIALS AND METHODS: For this purpose, mandibular bone defects were surgically introduced into the mandibles of minipigs and the scaffold of the defect site was modeled by computer-aided design/computer-aided manufacturing technique. Autologous bone cells from porcine calvaria were harvested from minipigs and grown in culture. Cells were seeded on scaffolds generated by rapid prototyping of polylactic acid/polyglycolic acid copolymers. The defects were then reconstructed by implanting the tissue constructs. RESULTS: The intraoperative sites as well as the postoperative computerized tomographic scans demonstrated an accurate fit in the defect sites. The implanted scaffold constructs enriched with osteoblast-like cells were well tolerated and appeared to support bone formation, as revealed by histologic and immunohistochemical analyses. DISCUSSION: These results indicated that in vitro expanded osteoblast-like cells spread on a resorbable individualized scaffold can be capable of promoting the repair of bony defects in vivo. CONCLUSION: These results warrant further attempts to combine computer modeling and tissue engineering for use in bone reconstructive surgery.

Animals↗