Biomedical subjects
Publications and source records attributed to Arif Ozdemir.
The occurrence of both primary gastric lymphoma and gastric adenocarcinoma in the same patient is a rare entity. The possible causative factors of synchronous or metachronous occurrence of both malignancies and varieties in the treatment modalities are reviewed according to published cases in English language medical literature.
Fanconi anemia, an autosomal recessive and X-linked disorder, is known to be associated with a variety of neoplasms. Liver tumors are one of the most frequently observed neoplasms but the association between the two disorders remains obscure. We present a case of a 27-year old female Fanconi anemia patient diagnosed with a mass on the right lobe of the liver measuring 90x75x60 mm. Histopathological examination of the mass after right hepatic lobectomy revealed focal nodular hyperplasia. This appears to be the first reported case of a hepatic focal nodular hyperplasia of such proportion associated with Fanconi anemia. Previously reported cases of liver tumors in association with Fanconi anemia in the English Literature were either hepatocellular carcinomas or hepatic adenomas.
Hemangioma is the most common primary tumor of the liver. The widespread use of ultrasonography (USG) and computed tomography (CT) has made the diagnosis more common. Although the vast majority of hemangiomas are diagnosed incidentally and are asymptomatic, treatment is still controversial. Surgery is the treatment of choice, especially in giant, symptomatic hemangiomas and uncertainty of diagnosis. Twenty-two patients (median age: 46 years) underwent resection (n = 12) or enucleation (n = 10) for liver hemangioma from 1989 to 2002. The primary indication for surgery was abdominal pain. Ten patients who were treated by enucleation were compared with twelve patients who were treated by liver resection. Mean tumor size was 90 mm with a range of 40-270 mm. There were no statistically significant differences in tumor size, preoperative liver function tests, hemoglobin levels, and platelet counts between the two groups. Operative time was longer in the resection group, and statistically significant the difference was (p = 0.048). Blood transfusion requirement and blood loss during intraoperative period were higher in the resection group (p = 0.025, p = 0.01, respectively). There were three postoperative complications, 1 in the enucleation group (pleural effusion), 2 in the resection group (liver abscess and wound infection). There was no surgery-related mortality in either group. Although most hemangiomas can be removed by enucleation or liver resection with low morbidity and mortality, if the location and number of hemangiomas are appropriate, enucleation is the choice of the therapy. Hospital stay, blood transfusion requirement, and blood loss can be kept minimal by the selection of enucleation.
BACKGROUND/AIMS: We have previously shown that in the canine small bowel autotransplantation model, adding alpha - tocopherol to Euro Collins solution for perfusion enhanced the integrity of the small bowel mucosa for up to 12 hours in the posttransplantation period. The purpose of this study was to investigate the effects of verapamil and a tocopherol on reperfusion injury in the canine small bowel autotransplantation model. METHODS: The study consisted of four groups of six animals each. In Group 1 (control group) grafts were perfused with Euro Collins solution while those of Group 2 were perfused with Euro Collins and alpha- tocopherol. Group 3 grafts were perfused with Euro Collins + verapamil and Group 4 with Euro Collins, alpha- tocopherol and verapamil. Autotransplantation model was used to avoid immunological injury. Graft function and mucosal integrity were assessed by the analysis of enzymatic activities (mucosal glutaminase, maltase and lactase) and histopathological examination. Malonyldialdehyde (per gram tissue) was used as an indicator of lipid peroxidation. RESULTS: Glutaminase activity of Group 4 was found to be higher than that of the other groups at all time points (p<0.05). In the verapamil group (Group 3), the amount of lipid peroxidation showed the greatest decrease in comparison to other groups at the 12 hour time point (p<0.05). Maltase activity in Group 3 was significantly different at all time points (p<0.05). Lactase activity showed no significant difference between groups at each time point. The microscopic appearance of tissue injury shown by histopathological examination of tissue samples obtained at different time points was related to decrease in mucosal enzymatic activities. CONCLUSIONS: alpha- tocopherol is a promising agent for the prevention of tissue injury caused by free oxygen radicals during organ transplantation. Verapamil, as an antioxidant, also has preventive effects in organ preservation. Using verapamil together with alpha- tocopherol in the same preservation solution did not increase the preventive effect of alpha- tocopherol.
The abdominal cocoon is a rare disease that is characterized by a total or partial encasement of the small bowel by a thick and fibrotic membrane. Thirty-five cases were reported since it was first described. It occurs primarily in females. Preoperative diagnosis is a matter of challenge and usually made at laparotomy. We report a patient with partial intestinal obstruction and abdominal cocoon which was diagnosed peri-operatively. We review the literature and discuss the etiology of this disease.
BACKGROUND/AIMS: We have previously shown that alpha tocopherol is a potent antioxidant which prevents reperfusion injury in a kidney and small bowel autotransplant model. In this study, the effect of systemic alpha tocopherol and verapamil on small bowel and hepatic functions following mesenteric ischemi-reperfusion was evaluated. METHODS: Fourty male Wistar Albino rats (weight, 250-300 g) all subjected to an ischemia-reperfusion experiment were divided into four groups of 10 as follows: Group 1: (SHAM), Group 2, given prophylactic and systemic alpha tocopherol, Group 3: given verapamil and Group 4: given (both verapamil and alpha tocopherol). RESULTS: Glutaminase activities 120 minutes after reperfusion were found to be significant in liver tissues (p=0.004). The highest to the lowest glutaminase activities in liver tissue at 120 minutes after reperfusion were in Group 1, Group 3, Group 2 and Group 4 respectively. Significant differences in MDA levels were found in the small bowel at 30 minutes and 120 minutes time points (p<0.05). There were statistically significant higher glutaminase levels at 30 minutes and 120 minutes of reperfusion in the small bowel, especially in Group 4 (p=0.005). CONCLUSION: Both small bowel and liver injuries reperfusion, can be decreased by prophylactic use of alpha tocopherol and verapamil. Glutaminase activity in liver tissue can also be affected by small bowel ischemia-reperfusion.