Biomedical subjects

Arkadiusz Pogrzebielski

Publications and source records attributed to Arkadiusz Pogrzebielski.

6 recordsLinked to original sources

PubMed2006

Uveal melanoma in young patients.

INTRODUCTION: This study aimed to investigate the clinical profile of young patients with uveal melanoma treated in 1995-2002 in the Department of Ophthalmology, Jagiellonian University, Krakow, Poland. METHODS: Retrospective case-control series. RESULTS: Out of 800 patients with uveal melanoma treated between 1995 and 2002, there were 11 patients (1.4%) aged 20 or younger. The mean age of those patients was 17.9 (12-20, median 19) years. There were five men (45%) and six women (55%). In all cases, the tumor was unilateral. In five (45%) cases the tumor affected the right eye and in six (55%) cases the left eye. Eight (72%) patients were treated with local resection. Among these, eight patients, in two (18%) with iris or ciliary body melanoma we used adjuvant Ru-106 episcleral plaque brachytherapy (EPB). In two (18%) cases of choroidal melanoma, we performed I-125 EPB: one case ended with regression of the tumor, while the second did not respond to EPB and we had to enucleate the eye. In one (9%) case we performed enucleation as the primary treatment. The mean follow-up was 61.4 months, ranging 30-125 months. All those patients are still alive and no metastases were detected. CONCLUSIONS: Uveal melanoma is a rare malignancy in children and teenagers. In the present series, it occurred in the iris in more than 50% of cases.

Adolescent↗

PubMed2006

[Retinoblastoma update--management and classification (Part I)].

The aim of this paper is to present updated data on diagnosis, management and classification of retinoblastoma. The authors describe the growth patterns of retinoblastoma including the diffuse infiltrating type, the features of sponatneously regressed and sponatneously arrested retinoblastoma. In addition, retinoblastoma genetics including 13 q deletion syndrome, are discussed. Finally, they present the International Intraocular Retinoblastoma Classification (IIRC) and make recommendations regarding chemotherapy after enucleation based on histopathology findings.

Antineoplastic Agents↗

PubMed2006

[Retinoblastoma update--therapy (Part II)].

The aim of this paper is to present updated data on the treatment of retinoblastoma. The authors describe current management based on the International Intraocular Retinoblastoma Classification (IIRC). They discuss the different methods of treatment, including chemoreduction, subconjunctival carboplatin, transpupillar thermotherapy, cryotherapy, laser photocoagulation, episcleral plaque radiotherapy, external-beem radiotherapy and enucleation.

Antineoplastic Agents↗

PubMed2005

[The analysis of I125 brachytherapy complications in cases of uveal melanoma].

PURPOSE: Analysis of type and frequency of complications after brachytherapy 1125 between 1-12 months after treatment and during the following controls. MATERIALS AND METHODS: 147 persons (76 men and 71 women) aged 23-86 years (mean 57 years), were treated in our clinic in 1998-2001. In 43% of the cases the thickness of the tumor was more than 8 mm and in 94% the maximum diameter was bigger than 8.1 mm. The irradiation dose was 80-120 Gy, mean 100 Gy. RESULTS: Regression and stabilization of the tumor was achieved in 84.3% of all cases. Complications of different type and intensity associated with brachytherapy I125 were observed in majority of the cases. The complications observed were: radiation retinopathy (52%), radiation maculopathy (33.6%), radiation optic neuropathy (25.3%), vitreous hemorrhage (8.8%), glaucoma (20.5%) and cataract (18.5%). CONCLUSIONS: 125I brachytherapy yields good results in cases of uveal melanoma, however it's associated with post radiation complications.

Adult↗

PubMed2005

[Optic disc melanocytoma].

PURPOSE: Presentation of the cases of melanocytoma observed in the latest time in our clinic. MATERIAL AND METHODS: We present 2 cases - one in a 41 years old women S.M. and in a 77 years old women P.J. CONCLUSIONS: In case of melanocytoma there should be performed specialistic ancillary tests and the patients should be observed with photographic documentation.

Adult↗

PubMed2004

[Epidemiology of choroidal melanoma in the material of the Department of Ophthalmology CM UJ in Cracow].

PURPOSE: Epidemiological analysis of the choroidal melanoma cases-sent from all over the Poland and treated in our clinic between January 1998 and December 2002. MATERIAL AND METHODS: The study included 687 patients with choroidal melanoma 348 women and 339 men. RESULTS: The age of patients was 14-97 years (mean 56 years). The most numerous group consisted of patients between 60-70 years of age (22.7%). Most of the cases came from the regions of Malopolska, Silesia, Lower-Silesia and Mazovia. The time between first symptoms and the first visit in our clinic was between 1 week to 2 years. According to the COMS classification we found small melanoma in 13% of cases, medium in 51% and large in 36% of cases. We found the presence of other malignancies besides the choroidal melanoma in 4.3% patients. We analyzed the demography and positive family history of ocular and general malignancies in the patients.

Adolescent↗